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Using miRNA-gene co-expression networks to predict abnormal gap junctional communication in anthracycline-treated cardiomyocytes

A network prediction, cardiomyocyte technology, applied in the field of miRNA-gene co-expression network, can solve problems such as heart damage

Active Publication Date: 2021-06-15
JINZHOU MEDICAL UNIV
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Problems solved by technology

Both clinical research and practical observation have shown that the cardiotoxicity caused by anthracyclines is often progressive and irreversible, especially the initial use of anthracyclines may cause heart damage

Method used

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Embodiment Construction

[0037] Gap junction (Gap junction, GJ), also known as gap leveling or between smooth muscle and nerve cells, can transmit electrical impulses through this. Structural and functional integrity of gap junctions in synchronous contraction of myocardium. Cardiomyocytes transmit ions, small molecular metabolites and secondary messengers through gap junctions, providing a low-resistance conduction path between cardiomyocytes, and their activities are coordinated. Due to the different types, sizes, and distribution patterns of gap junctions on the cell surface, the biological and physical characteristics of the connecting channels between cells are also different, which is manifested as the difference in impedance between cells, and the propagation of excitement is discontinuous. Under pathological conditions, the expression and function of gap junction genes will change, resulting in altered electrical activity between cells. The technical solution disclosed by the invention is hel...

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Abstract

The invention relates to a method for predicting anthracycline drug cardiomyocyte gap junction communication abnormality using miRNA-gene co-expression network, comprising the following steps: Step 1: Experimental grouping; Step 2: RNA extraction; Step 3: miRNA-gene chip data Differential expression analysis; step 4: miRNA target gene analysis and regulatory network construction. The present invention uses the miRNA-gene co-expression network to predict the abnormality of anthracycline drug cardiomyocyte gap junction communication, and predicts the abnormal cardiomyocyte gap junction communication through the miRNA-gene co-expression network, which is a new molecular marker for discovering anthracycline drug cardiotoxicity A new approach is provided, which provides a reference for predicting its prognosis.

Description

technical field [0001] The invention relates to a miRNA-gene co-expression network, in particular to a method for predicting anthracycline drug cardiomyocyte gap junction communication abnormality by using the miRNA-gene co-expression network. Background technique [0002] Anthracyclines, including Doxorubicin (DOX), Epirubicin (EPI) and Pirarubicin (THP), are widely used in the treatment of hematological malignancies and solid tumors, such as breast Cancer, lymphoma, acute leukemia, etc. Combination therapy based on anthracyclines is usually the standard first-line treatment, with definite curative effect and indispensable, but it can cause toxic and side effects such as hair loss, bone marrow suppression and cardiotoxicity. Cardiotoxicity (Anthracycline Induced Cardiotoxicity, AIC) is the most serious side effect of anthracyclines. Van et al. used Meta-analysis to show that coenzyme Q10, levocarnitine, N-acetylcysteine, VC and VE had no obvious cardioprotective effect on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16C20/30G16C20/50G16C20/80G16C20/70
Inventor 王亚帝何东宁陈素贤陈书睿林琳
Owner JINZHOU MEDICAL UNIV
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