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Electrolytic buffer generator

A buffer and buffer solution technology, applied in the field of electrolytic buffer generators, can solve problems such as overshoot

Pending Publication Date: 2018-11-27
BOARD OF RGT THE UNIV OF TEXAS SYST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While it is common practice to adjust the pH of a buffer solution with concentrated strong acids or bases, it is easy to overadjust by adding too much titrant and having to prepare another solution and start all over again

Method used

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Examples

Experimental program
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example 1

[0118] 1a. Principle

[0119] A suppressor-based electrodialysis buffer generator. Such as Figure 5 As described in (a), a completely neutralized Na salt of n-protonic acid (Na n X) The solution flows into the CEM-based suppressor, and the Na + The current I is at least partially electrodialyzed and replaced. For simplicity, assume a NaX-HX buffer system, but the basic scheme can be applied to the corresponding multi-proton acid-base system. NaX flows through the central channel at Q mL / min and molar concentration C, while the current i mA flows through the system. Non-H in significant concentration + / Non-OH - Under the condition that ions are still to be transmitted, the efficiency of this suppressor can be considered as Faraday's. In a steady state, 0.06i / F mol / min of Na is removed from the center + To the negative electrode chamber, and introduce an equal amount of H from the anode chamber + . In total, this formed HX equal to 60i / FQ M in the central channel, while the Na...

example 1

[0129] Experimental part

[0130] Reagents. All chemicals are commonly available reagent grade and use distilled deionized water from start to finish. See example 1c.

[0131] Disodium hydrogen phosphate heptahydrate and sodium citrate dihydrate were purchased from Mallinckrodt. Ethylenediamine dihydrochloride was purchased from Acros Organics. Tris(hydroxymethyl)aminomethane hydrochloride and dipotassium hydrogen phosphate were purchased from J.T. Baker. All chemicals are reagent grade, and the solution is prepared with 18.2 MΩ·cm Milli-Q (Millipore) deionized water.

[0132] Such as Picture 12 As shown in, noise was observed without the CRD gas removal device. The pH electrode flow cell basically has no back pressure, and the pH trace shows that as the current increases, the noise burr increases. Noise with a larger frequency was also observed on the conductivity trace at increasing current levels (except for glitches, thicker traces were observed as a result of noise origin...

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PUM

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Abstract

Buffer generators are described based on electrodialytic devices. The methods of using these devices can generate buffers for diverse applications, including separations, e.g., HPLC and ion chromatography. Also provided are chromatographic devices including the buffer generators, generally located upstream from a chromatography column, sample injector valve or both.

Description

[0001] This application is a divisional application of the invention patent application entitled "Electrolytic Buffer Generator" with the international filing date of August 23, 2012 and the Chinese national phase application number being 201280040845.2. [0002] Cross references to related applications [0003] This application requires the US provisional patent application with serial number 61 / 526,592 filed by Purnendu K. Dasgupta, Yongjing Chen, and Kannan Srinivasan on August 23, 2011 for the "Three-electrode Buffer Generator and Method", and by Purnendu K. Dasgupta, Yongjing Chen, and Kannan Srinivasan filed a U.S. Provisional Patent Application Serial No. 61 / 528,127 for "Membrane Suppressor Buffer Generator" on August 26, 2011. Priority under 35U.SC§119(e) Rights and interests, all the disclosures of these provisional patent applications are incorporated herein by reference. Background technique [0004] Buffers are widely used for pH control in chemical methods. When acids ...

Claims

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Application Information

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IPC IPC(8): B01D61/44B01D61/48B01D61/46
CPCB01D61/44B01D61/445B01D61/46G01N30/34B01D15/168C25B7/00Y02E60/50B01D61/468B01D2311/18B01D2311/2653
Inventor P·K·达斯谷普塔陈永菁K·斯里尼瓦桑
Owner BOARD OF RGT THE UNIV OF TEXAS SYST