A kind of florfenicol solution and preparation method thereof

The technology of florfenicol and solution is applied in the field of preparation of florfenicol solution and can solve the problems such as difficulty in clinical medication of florfenicol

Active Publication Date: 2021-04-06
山西瑞象生物药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the difficult problem of existing florfenicol clinical medication, the present invention provides a florfenicol solution with high solubility, stable solution and no toxic or side effect solvent

Method used

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  • A kind of florfenicol solution and preparation method thereof
  • A kind of florfenicol solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A Florfenicol solution, consisting of Florfenicol 5g, propylene glycol 30ml, glycerin 20ml, sodium citrate 1.8g, Span 20 0.01g, ethyl cellulose 0.2g, hydroxypropyl methylcellulose 0.3 g, an appropriate amount of citric acid, and water to 100ml.

[0023] The preparation method of the Florfenicol solution of the present embodiment comprises the following steps:

[0024] 1) Take 20ml of water, add sodium citrate and stir to dissolve, add wetting agent and organic solvent and mix evenly, heat up to 50°C together, and add florfenicol while stirring;

[0025] 2) After cooling the above solution to room temperature, add a solution stabilizer and mix well;

[0026] 3) Use citric acid to adjust the pH of the solution to 5.5, dilute to 100ml with water, and stir evenly.

Embodiment 2

[0028] A Florfenicol solution, consisting of Florfenicol 20g, Propylene Glycol 42ml, Glycerin 10ml, Sodium Citrate 2.0g, Tween 20 0.02g, Span 20 0.02g, Hypromellose 1.2g , an appropriate amount of citric acid, and water to 100ml.

[0029] The preparation method of the Florfenicol solution of the present embodiment comprises the following steps:

[0030] 1) Take 10ml of water, add sodium citrate and stir to dissolve, add wetting agent and organic solvent and mix evenly, heat up to 40°C together, and add florfenicol while stirring;

[0031] 2) After cooling the above solution to room temperature, add a solution stabilizer and mix well;

[0032] 3) Use citric acid to adjust the pH of the solution to 7.5, dilute to 100ml with water, and stir evenly.

Embodiment 3

[0034] A Florfenicol solution, Florfenicol 30g, Propylene Glycol 50%ml, Glycerol 8ml, Sodium Citrate 2.2g, Span 20 0.05%g, Hypromellose 1.5g, Citric Acid amount , water quantitatively to 100ml.

[0035] The preparation method of the Florfenicol solution of the present embodiment comprises the following steps:

[0036] 1) Take 10ml of water, add sodium citrate and stir to dissolve, add wetting agent and organic solvent and mix evenly, heat up to 60°C together, and add florfenicol while stirring;

[0037] 2) After cooling the above solution to room temperature, add a solution stabilizer and mix well;

[0038] 3) Use citric acid to adjust the pH of the solution to 6.5, dilute to 100ml with water, and stir evenly.

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PUM

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Abstract

The invention provides a florfenicol solution, which is composed of florfenicol, an organic solvent, a cosolvent, a wetting agent, a pH buffer, a solution stabilizer and water. On the one hand, the florfenicol solution of the present invention effectively solves the problem of unstable and easy precipitation of the florfenicol soluble powder in the prior art; Dimethylformamide, dimethylacetamide, dimethyl sulfoxide, etc. with irritating odor and toxic side effects are used as adverse reactions caused by solvents.

Description

technical field [0001] The invention relates to the field of preparation of florfenicol formulations, in particular to the preparation of a florfenicol solution. Background technique [0002] Florfenicol (florfenicol), also known as florfenicol, is a new type of chloramphenicol-type broad-spectrum antibacterial drug for veterinary medicine successfully developed by Schering-Plough in 1988. It is one of the four antibacterial agents certified by the US FDA. one. Its chemical name is D(+)-threo-1-p-thiamphenylphenyl-2-dichloroacetamido-3-fluoropropanol. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safety and high efficiency, low incidence of drug resistance, etc., and has a remarkable therapeutic effect on bacterial diseases of livestock and poultry caused by sensitive bacteria. [0003] Compared with similar antibiotics, florfenicol has excellent performance, but its poor water solubility affects its bioavailabi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/165A61K47/38A61K47/10A61P31/04
CPCA61K9/0095A61K31/165A61K47/10A61K47/38A61P31/04
Inventor 高木珍夏雪林聂丽娜刘爱玲李守军
Owner 山西瑞象生物药业有限公司
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