A kind of florfenicol solution and preparation method thereof
The technology of florfenicol and solution is applied in the field of preparation of florfenicol solution and can solve the problems such as difficulty in clinical medication of florfenicol
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Embodiment 1
[0022] A Florfenicol solution, consisting of Florfenicol 5g, propylene glycol 30ml, glycerin 20ml, sodium citrate 1.8g, Span 20 0.01g, ethyl cellulose 0.2g, hydroxypropyl methylcellulose 0.3 g, an appropriate amount of citric acid, and water to 100ml.
[0023] The preparation method of the Florfenicol solution of the present embodiment comprises the following steps:
[0024] 1) Take 20ml of water, add sodium citrate and stir to dissolve, add wetting agent and organic solvent and mix evenly, heat up to 50°C together, and add florfenicol while stirring;
[0025] 2) After cooling the above solution to room temperature, add a solution stabilizer and mix well;
[0026] 3) Use citric acid to adjust the pH of the solution to 5.5, dilute to 100ml with water, and stir evenly.
Embodiment 2
[0028] A Florfenicol solution, consisting of Florfenicol 20g, Propylene Glycol 42ml, Glycerin 10ml, Sodium Citrate 2.0g, Tween 20 0.02g, Span 20 0.02g, Hypromellose 1.2g , an appropriate amount of citric acid, and water to 100ml.
[0029] The preparation method of the Florfenicol solution of the present embodiment comprises the following steps:
[0030] 1) Take 10ml of water, add sodium citrate and stir to dissolve, add wetting agent and organic solvent and mix evenly, heat up to 40°C together, and add florfenicol while stirring;
[0031] 2) After cooling the above solution to room temperature, add a solution stabilizer and mix well;
[0032] 3) Use citric acid to adjust the pH of the solution to 7.5, dilute to 100ml with water, and stir evenly.
Embodiment 3
[0034] A Florfenicol solution, Florfenicol 30g, Propylene Glycol 50%ml, Glycerol 8ml, Sodium Citrate 2.2g, Span 20 0.05%g, Hypromellose 1.5g, Citric Acid amount , water quantitatively to 100ml.
[0035] The preparation method of the Florfenicol solution of the present embodiment comprises the following steps:
[0036] 1) Take 10ml of water, add sodium citrate and stir to dissolve, add wetting agent and organic solvent and mix evenly, heat up to 60°C together, and add florfenicol while stirring;
[0037] 2) After cooling the above solution to room temperature, add a solution stabilizer and mix well;
[0038] 3) Use citric acid to adjust the pH of the solution to 6.5, dilute to 100ml with water, and stir evenly.
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