Novel use of Polymerase I inhibitor

Abstract

The invention belongs to the technical field of biological medicine and specifically discloses a novel use of a Polymerase I inhibitor. The novel use of the Polymerase I inhibitor is studied in the cellular level and the animal experimental level. The Polymerase I inhibitor can inhibit the activity of IL-2, NFATc2, NFkB and IFN-gamma thereby inhibiting the proliferation of T cells, further regulating and controlling the T cell activation and the immune response of the human body and inhibiting the immune rejection of the organ allograft. The Polymerase I inhibitor can be used for preparation of agents for inhibiting the activity of IL-2, NFATc2, NFkB and IFN-gamma, T cell proliferation, T cell activation or immune rejection of the organ allograft and has a large application prospect.

Description

technical field

[0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the use of Polymerase I inhibitors in the preparation of immunosuppressants. Background technique

[0002] The existence of the immune system is to prevent the invasion of pathogenic bacteria, but some cells, tissue proteins or other components in some individuals will have an abnormal immune reaction with the immune system, and the individual will produce T cells that attack their own cells or any proteins outside the cells or Lesions caused by autoantibodies are autoimmune diseases. The etiology of autoimmune diseases is extremely complex, so the current clinical treatment can only start from the symptoms of the appearance, such as giving patients immunosuppressants to relieve their pain. In a broad sense, drugs that can reduce immunity are called immunosuppressants, which can reduce immunity after taking or injection. Therefore, immunosuppressants are ma...

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