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Nano-emulsion composite, and preparation method and application thereof

A compound and nanoemulsion technology, which is applied in the direction of pharmaceutical formula, plant raw materials, emulsion delivery, etc., can solve problems such as human injury, and achieve enhanced solubility and excellent anti-inflammatory effects

Pending Publication Date: 2018-12-07
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most people suffer from dental and oral diseases more or less, the more common ones are periodontitis, gingival swelling and pain, gingival bleeding, etc. These dental problems are caused by chronic inflammation caused by bacteria invading the gums and periodontal tissue. A destructive disease, anti-inflammatory is fundamental, and most toothpastes sold on the market are aimed at ordinary consumers, and are not suitable for special oral patients with dental diseases, and many anti-inflammatory toothpastes contain chemicals such as preservatives to treat teeth It is a long-term process, and long-term use will cause great harm to the human body

Method used

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  • Nano-emulsion composite, and preparation method and application thereof
  • Nano-emulsion composite, and preparation method and application thereof
  • Nano-emulsion composite, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Take by weighing thymol in the embodiment 1 of table 1 to obtain cosurfactant in dehydrated alcohol;

[0033] Weigh the main components in Example 1 of Table 1, add additives and stir in a high-pressure homogenizer until the nanoemulsion composite is obtained in a transparent liquid state, wherein the chrysin is silk fibroin-modified chrysin, and the preparation method includes The steps are as follows: dissolve chrysin with polyethylene glycol to 5 mg / ml, add silk fibroin solution, incubate at room temperature for 24 hours, mix well, centrifuge, wash the precipitate, freeze-dry, and crush to obtain.

Embodiment 2

[0035] Take by weighing thymol in the embodiment 2 of table 1 to obtain cosurfactant in dehydrated alcohol;

[0036]Weigh the main components in Example 2 of Table 1, add additives and stir in a high-pressure homogenizer until the nanoemulsion composite is obtained in a transparent liquid state, wherein the chrysin is silk fibroin-modified chrysin, and the preparation method includes The steps are as follows: dissolve chrysin with polyethylene glycol to 5.2 mg / ml, add silk fibroin solution, incubate at room temperature for 25 hours, mix well, centrifuge, wash the precipitate, freeze-dry, and crush to obtain.

Embodiment 3

[0038] Take by weighing thymol in the embodiment 3 of table 1 to obtain cosurfactant in dehydrated alcohol;

[0039] Weigh the main components in Example 3 of Table 1 and add additives and stir in a high-pressure homogenizer until the nanoemulsion complex is obtained in a transparent liquid state, wherein the chrysin is silk fibroin-modified chrysin, and the preparation method includes The following steps: dissolve chrysin with polyethylene glycol to 5.5 mg / ml, add silk fibroin solution, incubate at room temperature for 26 hours, mix well, centrifuge, wash the precipitate, freeze-dry, and crush to obtain.

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PUM

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Abstract

The invention relates to a nano-emulsion composite, and particularly relates to a nano-composite and a preparation method, and belongs to the field of composite materials. The nano-emulsion compositeincludes a main component and an additive, wherein the main component comprises, by weight, 1-20 parts of ocimum gratissimum oil, 2-10 parts of chrysin, 1-5 parts of grapefruit essential oil, 1-5 parts of wintergreen oil, 1-15 parts of dementholized peppermint oil, 1-5 parts of eucalyptus oil, 1-10 parts of star anise oil, 1-10 parts of spearmint oil, 1-10 parts of geranium oil, and 1-5 parts of betulin. In the nano-emulsion composite, on the basis of the ocimum gratissimum oil, the chrysin is added to remove free radicals, the grapefruit essential oil is added to increasing solubility of different essential oil, the betulin is added for sterilization and antiviral function. Meanwhile, by means of addition of the surfactant, the nano-emulsion composite has anti-inflammation and antiviral functions.

Description

field of invention [0001] The invention relates to a nano-emulsion compound, in particular to a nano-emulsion compound and a preparation method, and belongs to the field of composite materials. Background technique [0002] With the improvement of people's living standards, people's diets have become more diversified, and their lives have become more and more irregular. Although there are many types of food and rich nutrition, the food is too complicated, which is easy to breed bacteria. Many modern people's mouths and teeth have or More or less ailments. [0003] Most people suffer from dental and oral diseases more or less, the more common ones are periodontitis, gingival swelling, bleeding gums, etc. These dental problems are chronic inflammation caused by bacteria invading the gums and periodontal tissue. A destructive disease, anti-inflammatory is fundamental, and most toothpastes sold on the market are aimed at ordinary consumers, and are not suitable for special oral...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/107A61K36/752A61K47/44A61K47/64A61P31/04A61P31/12A61K8/92A61K8/63A61K8/49A61Q11/00A61K31/352A61K31/56A61K36/185A61K36/53A61K36/534A61K36/57A61K36/61
CPCA61K9/1075A61K8/498A61K8/63A61K8/922A61K9/06A61K31/352A61K31/56A61K36/185A61K36/53A61K36/534A61K36/57A61K36/61A61K36/752A61K47/44A61K47/64A61P31/04A61P31/12A61Q11/00A61K2300/00
Inventor 周海滨江海龙陈旦凤洪舟
Owner NINGBO LIWAH PHARM CO LTD
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