Vitamin K composition, and preparation method, preparation and applications thereof

A technology for vitamins and compositions is applied in the field of vitamin K compositions to achieve the effects of improving stability and convenience of taking, uniform and rapid distribution, and increasing specific surface area

Inactive Publication Date: 2018-12-07
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, liquid preparations also have problem

Method used

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  • Vitamin K composition, and preparation method, preparation and applications thereof
  • Vitamin K composition, and preparation method, preparation and applications thereof
  • Vitamin K composition, and preparation method, preparation and applications thereof

Examples

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preparation example Construction

[0054] (1) Preparation of vitamin K composition of the present invention

[0055] The "solid excipients" described in the following examples are excipients other than vitamin K, phospholipids, cholic acid compounds, co-surfactants, and carrier materials in the formula.

Embodiment 1

[0056] Embodiment 1: Preparation of vitamin K composition

[0057]

[0058] Preparation method: Stir and dissolve egg yolk lecithin, propylene glycol and vitamin K1 in a constant temperature water bath at 50°C, and mix well. Add deoxycholic acid and continue to stir until it is completely dissolved, forming a uniform transparent yellow solution. Add it dropwise to micropowdered silica gel, grind and mix to form liquid-solid compressed powder. Add solid auxiliary materials and mix to obtain the vitamin K composition. The obtained vitamin K composition can be directly powdered and compressed into tablets or divided into hard capsules, or directly divided into the pharmaceutical preparation of the present invention in the form of dry suspension in packaging bags.

Embodiment 2

[0059] Embodiment 2: Preparation of vitamin K composition

[0060]

[0061]

[0062] Preparation method: Stir and dissolve DSPE-mPEG, egg yolk lecithin, diethylene glycol monoethyl ether and vitamin K1 in a constant temperature water bath at 50°C, and mix well. Add glycocholic acid and continue to stir until completely dissolved, forming a homogeneous transparent yellow solution. Add dropwise to anhydrous calcium phosphate, grind and mix to form liquid-solid compressed powder. Add solid auxiliary materials and mix to obtain the vitamin K composition. The obtained vitamin K composition can be directly powdered and compressed into tablets or divided into hard capsules, or directly divided into the pharmaceutical preparation of the present invention in the form of dry suspension in packaging bags.

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Abstract

The invention discloses a vitamin K composition, and a preparation method, a preparation and applications thereof. The vitamin K composition contains a carrier material and a solid accessory ingredient besides the carrier material; the carrier material is loaded with vitamin K, a cholic acid compound, a phosphatide, a cosurfactant, and a random selected oil through adsorption; the vitamin K composition is capable of realizing self emulsifying in an aqueous solution with a pH value ranging from 1.0 to 8.0 so as to obtain a stable nanometer emulsion; the in vitro dissolving out and in vivo bioavailability of vitamin K are increased obviously; the vitamin K composition is a solid composition, so that defects of liquid preparations in stability and using convenience are avoided; and the vitamin K composition is suitable for patients with bile duct obstruction.

Description

technical field [0001] The invention relates to a vitamin K composition and its preparation method, preparation and application. Background technique [0002] Vitamin K is a group of fat-soluble vitamins, mainly including vitamin K1, vitamin K2, vitamin K3 and vitamin K4, among which vitamin K1 and vitamin K2 exist in nature, and vitamin K3 and vitamin K4 are synthetic. Vitamin K plays an important role in many important physiological functions of the body. As a coenzyme of carboxylase, vitamin K participates in the synthesis of coagulation factors II, VII, IX and X in the liver. It is often used clinically to treat hemorrhage caused by vitamin K deficiency or prothrombin deficiency and neonatal hemorrhage, and can also be used as an anticoagulant ( Such as the rescue of anticoagulant rodenticide) poisoning. Vitamin K is also involved in human bone metabolism and can be used to treat osteoporosis. In addition, vitamins are also used in anti-tumor, analgesic, antibacterial...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K47/28A61K47/24A61P3/02A61P7/04A61P39/02A61P19/10A61P35/00A61P29/00A61P31/04
CPCA61K31/122A61K47/24A61K47/28A61K2300/00
Inventor 高春生龚伟王玉丽杨美燕杨佳慧仝永涛
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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