Functional composite dressing with drug sustained release and self-antibacterial effects and preparation method thereof

A slow-release, drug-based technology, applied in dressings, viscous dressings, non-adhesive dressings, etc., can solve problems such as not being able to be used for a long time, easy to breed bacteria, and easy to stick to granulation, so as to reduce the frequency, reduce the chance of re-injury, reduce The effect of wound scars

Inactive Publication Date: 2018-12-07
吉林康众新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problems that existing polyurethane foam dressings are easy to breed bacteria, cannot be used for a l

Method used

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  • Functional composite dressing with drug sustained release and self-antibacterial effects and preparation method thereof
  • Functional composite dressing with drug sustained release and self-antibacterial effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0046] The method for preparing the above-mentioned functional composite dressing with sustained drug release and self-antibacterial effects includes the following steps:

[0047] Step 1: Prepare the wound contact layer 1 by the immersion phase precipitation transformation method;

[0048] Add 100 parts by weight of polylactic acid particles, 10-30 parts by weight of polyethylene glycol, and 2-12 parts by weight of sustained-release drugs into the container containing N-methylpyrrolidone, mix and stir to dissolve completely, and prepare A uniform solution with a solid content of 20% to 60%, after deaeration, is evenly coated on the release paper by a coating machine, and then the release paper coated with the mixture layer is soaked in the ethanol solution for 5 to 30 minutes, and then placed Dry the solvent in an oven at 70~100℃, take it out and peel off the release paper to obtain a thickness of 10~150μm, the surface contains evenly distributed through micropores with a diameter ...

Example Embodiment

[0055] Example 1

[0056] Step 1: Preparation of wound contact layer by immersion phase precipitation transformation method

[0057] Will 800g 80g of polyethylene glycol 200, 8g of anesthetic and 8g of coagulant were added to the container containing 5L of N-methylpyrrolidone one by one, mixed and stirred to dissolve completely, after defoaming, it was evenly coated on the release paper by a coating machine After soaking the release paper coated with the mixture layer in ethanol solution for 10 minutes, put it in an 80℃ oven to dry the solvent, take it out and peel off the release paper to obtain a thickness of 40μm, a surface diameter of 30μm, and a hole density 600 pcs / cm 2 Wound contact layer;

[0058] Step 2: Preparation of the outer protective layer

[0059] Put 700g of Add it to a container containing 2L of acetone, stir to dissolve it evenly, after deaeration, coat it evenly on the release paper by a coating machine, put it in a 40℃ oven to dry the solvent, take it out and p...

Example Embodiment

[0064] Example 2

[0065] Step 1: Preparation of wound contact layer by immersion phase precipitation transformation method

[0066] Put 1000g of 100g of polyethylene glycol 200, 10g of analgesic and 10g of anti-inflammatory drugs were added to the container containing 5L of N-methylpyrrolidone one by one, mixed and stirred to dissolve completely, after defoaming, it was evenly applied to the release by the coating machine On the paper, the release paper coated with the mixture layer is soaked in ethanol solution for 10 minutes, and then placed in an oven at 80°C to dry the solvent. After taking it out, peel off the release paper to obtain a thickness of 56μm and a surface pore size of 40μm. The hole density is 800 / cm 2 Wound contact layer;

[0067] Step 2: Preparation of the outer protective layer

[0068] Put 1000g of Add it to a container containing 2L of acetone, stir to dissolve it evenly, after deaeration, coat it evenly on the release paper by a coating machine, put it in a ...

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Abstract

The invention disclose a functional composite dressing with drug sustained release and self-antimicrobial effects and a preparation method thereof, belongs to the technical field of medical devices, and solves the technical problems that the existing polyurethane foam dressing has low tendency to breed bacteria, cannot be used for a long time, and has low tendency to adhere with granulation. The functional composite dressing is composed of a wound contact layer, a foam absorbing layer and an external protective layer arranged orderly from inside to outside, wherein the wound contact layer is acomposite material of a slow release medicine and degradable polylactic acid, and the surface of the wound contact layer contains permeation micropores; the foam absorbing layer is an aqueous polyurethane foam material, and the foam absorbing layer has an open cell unit. The external protective layer is thermoplastic polyurethane with a dense surface. The dressing has excellent antimicrobial effect, has low tendency to adhere to a wound, is low in frequency of dressing change, increases the comfort of patients while reducing the degree of skin scars, and is especially suitable for the treatment of wounds caused by device trauma, burns, bacterial fester and ulceration and other reasons.

Description

technical field [0001] The invention relates to a functional composite dressing with sustained drug release and self-antibacterial effects and a preparation method thereof, which belongs to the technical field of medical devices and is especially suitable for wound treatment of skin damage caused by device wounds, burns, bacterial infection and festering. Background technique [0002] Medically, the treatment of skin wounds is usually to cover the wound with a layer of medical dressing to prevent bacteria, dust and other debris from infecting the wound and protect the wound from healing. With the patients' requirements for comfortable experience in the process of wound healing, the types of dressings have also been continuously innovated and improved, gradually developing from traditional medical gauze to today's polyurethane foam wet dressings. [0003] Due to its excellent hydrophilic absorption, good air permeability and high mechanical strength, polyurethane foam dressin...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/44A61L15/46A61F13/00A61F13/02
CPCA61F13/00029A61F13/0206A61L15/26A61L15/44A61L15/46A61L2300/404A61L2300/602C08L67/04C08L75/04
Inventor 周金向刘佳陈德昀
Owner 吉林康众新材料科技有限公司
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