Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Functional composite dressing with drug sustained release and self-antibacterial effects and preparation method thereof

A slow-release, drug-based technology, applied in dressings, viscous dressings, non-adhesive dressings, etc., can solve problems such as not being able to be used for a long time, easy to breed bacteria, and easy to stick to granulation, so as to reduce the frequency, reduce the chance of re-injury, reduce The effect of wound scars

Inactive Publication Date: 2018-12-07
吉林康众新材料科技有限公司
View PDF7 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problems that existing polyurethane foam dressings are easy to breed bacteria, cannot be used for a long time, and are easy to stick to granulation, and provide a functional composite dressing with drug slow release and self-antibacterial effect and its preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Functional composite dressing with drug sustained release and self-antibacterial effects and preparation method thereof
  • Functional composite dressing with drug sustained release and self-antibacterial effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The preparation method of the above-mentioned functional composite dressing with drug sustained release and self-antibacterial effect, the steps are as follows:

[0047] Step 1, preparing the wound contact layer 1 by the immersion phase precipitation transformation method;

[0048] Add 100 parts by weight of polylactic acid granules, 10-30 parts by weight of polyethylene glycol, and 2-12 parts by weight of sustained-release drugs into a container containing N-methylpyrrolidone, mix and stir to dissolve completely, and prepare A uniform solution with a solid content of 20% to 60%, after defoaming, is evenly coated on the release paper by a coating machine, and then the release paper coated with the mixture layer is soaked in ethanol solution for 5 to 30 minutes, and then put Dry the solvent in an oven at 70-100°C, take it out and peel off the release paper to obtain transparent micropores with a thickness of 10-150 μm and a uniform distribution of pore diameters of 5-50 ...

Embodiment 1

[0056] Step 1. Preparation of wound contact layer by immersion phase precipitation transformation method

[0057] 800g of Add 80g of polyethylene glycol 200, 8g of anesthetic and 8g of blood coagulant into the container containing 5LN-methylpyrrolidone one by one, mix and stir to dissolve completely, and after defoaming, apply it evenly on the release paper by a coating machine , and then soak the release paper coated with the mixture layer in ethanol solution for 10 minutes, put it in an oven at 80°C to dry the solvent, take it out and peel off the release paper to obtain a thickness of 40 μm, a surface pore size of 30 μm, and a pore density of 600 pieces / cm 2 wound contact layer;

[0058] Step 2. Preparation of the external protective layer

[0059] 700g of Add it into a container containing 2L of acetone, stir and dissolve evenly, after defoaming, apply it evenly on the release paper with a coating machine, put it in a 40°C oven to dry the solvent, take it out and pee...

Embodiment 2

[0065] Step 1. Preparation of wound contact layer by immersion phase precipitation transformation method

[0066] 1000g of Add 100g of polyethylene glycol 200, 10g of analgesic and 10g of anti-inflammatory drug into the container containing 5LN-methylpyrrolidone one by one, mix and stir to dissolve completely, and after defoaming, apply it evenly on the release form with a coating machine On the paper, soak the release paper coated with the mixture layer in ethanol solution for 10 minutes, put it in an oven at 80°C to dry the solvent, take it out and peel off the release paper to obtain a thickness of 56 μm and a surface pore size of 40 μm. Hole density is 800 / cm 2 wound contact layer;

[0067] Step 2. Preparation of the external protective layer

[0068] 1000g of Add it into a container containing 2L of acetone, stir and dissolve evenly, after defoaming, apply it evenly on the release paper with a coating machine, put it in a 40°C oven to dry the solvent, take it out an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Diameteraaaaaaaaaa
Densityaaaaaaaaaa
Login to View More

Abstract

The invention disclose a functional composite dressing with drug sustained release and self-antimicrobial effects and a preparation method thereof, belongs to the technical field of medical devices, and solves the technical problems that the existing polyurethane foam dressing has low tendency to breed bacteria, cannot be used for a long time, and has low tendency to adhere with granulation. The functional composite dressing is composed of a wound contact layer, a foam absorbing layer and an external protective layer arranged orderly from inside to outside, wherein the wound contact layer is acomposite material of a slow release medicine and degradable polylactic acid, and the surface of the wound contact layer contains permeation micropores; the foam absorbing layer is an aqueous polyurethane foam material, and the foam absorbing layer has an open cell unit. The external protective layer is thermoplastic polyurethane with a dense surface. The dressing has excellent antimicrobial effect, has low tendency to adhere to a wound, is low in frequency of dressing change, increases the comfort of patients while reducing the degree of skin scars, and is especially suitable for the treatment of wounds caused by device trauma, burns, bacterial fester and ulceration and other reasons.

Description

technical field [0001] The invention relates to a functional composite dressing with sustained drug release and self-antibacterial effects and a preparation method thereof, which belongs to the technical field of medical devices and is especially suitable for wound treatment of skin damage caused by device wounds, burns, bacterial infection and festering. Background technique [0002] Medically, the treatment of skin wounds is usually to cover the wound with a layer of medical dressing to prevent bacteria, dust and other debris from infecting the wound and protect the wound from healing. With the patients' requirements for comfortable experience in the process of wound healing, the types of dressings have also been continuously innovated and improved, gradually developing from traditional medical gauze to today's polyurethane foam wet dressings. [0003] Due to its excellent hydrophilic absorption, good air permeability and high mechanical strength, polyurethane foam dressin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L15/26A61L15/44A61L15/46A61F13/00A61F13/02
CPCA61L15/26A61L15/44A61L15/46A61F13/0206A61L2300/404A61L2300/602A61F13/01029C08L67/04C08L75/04
Inventor 周金向刘佳陈德昀
Owner 吉林康众新材料科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com