Sustained release drug nanofibers and preparation method thereof
A technology of nanofibers and slow-release drugs, which is applied in the direction of pharmaceutical formulations, drug delivery, and medical preparations of non-active ingredients. It can solve problems such as unsatisfactory drugs, and achieve improved encapsulation efficiency, maintenance of biological activity, and long-term stable release. Effect
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[0045] see figure 2 , the embodiment of the present invention also provides a preparation method of the sustained-release drug nanofiber, comprising the following steps:
[0046] S100, providing the drug-loaded nano-microspheres 11;
[0047] S200, mixing the drug-loaded nano-microspheres 11 and the core layer sustained-release material in a solvent to obtain a core layer spinning solution;
[0048] S300, prepare a plurality of shell layer spinning solutions respectively, and each shell layer spinning solution includes a solution of the material of the nanofiber sustained-release layer 20;
[0049] S400, performing coaxial electrospinning on the core layer spinning solution and the plurality of shell layer spinning solutions with a coaxial spinning needle having a plurality of coaxially arranged liquid outlets , for simultaneously outputting the core layer spinning solution and the multiple shell layer spinning solutions.
[0050] The drug-loaded nano-microspheres 11 can be...
Example Embodiment
[0063] Example 1 Preparation of drug-loaded nano-microspheres 11
[0064] This example is used to prepare drug-loaded nano-microspheres 11 with two-layer nano-microsphere sustained-release layers, and the nano-microsphere sustained-release layers are respectively chitin layer and BSA layer.
[0065] Mix 80 μg of BMP-2 and 100 mg of BSA, and dissolve with 10 mL of deionized water under slight magnetic stirring to obtain a drug-loaded BSA aqueous solution;
[0066] Add 50 mg of chitin to 50 mL of 0.5wt% acetic acid solution, stir magnetically, and prepare a 1 mg / mL chitin solution;
[0067] Under the condition of magnetic stirring, a total of 40 mL of ethanol was uniformly injected into the drug-loaded BSA aqueous solution of the first step at a speed of 2 mL / h with a micro-syringe pump, and then stirred overnight;
[0068] Under the condition of magnetic stirring, 40 mL of the chitin solution prepared in the second step was injected at a constant speed of 0.5 mL / min with a mic...
Example Embodiment
[0071] Example 2 Preparation of drug-loaded nano-microspheres 11
[0072] The difference between this example and Example 1 is only that the nano-microsphere sustained-release layer of the drug-loaded nano-microsphere 11 has three layers, which are a chitin layer, a BSA layer and a chitin layer, respectively.
[0073] Mix 80 μg of BMP-2 and 100 mg of BSA, and dissolve with 10 mL of deionized water under slight magnetic stirring to obtain a drug-loaded BSA aqueous solution;
[0074] Add 50 mg of chitin to 50 mL of 0.5wt% acetic acid solution, stir magnetically, and prepare a 1 mg / mL chitin solution;
[0075] Under the condition of magnetic stirring, a total of 40 mL of ethanol was uniformly injected into the drug-loaded BSA aqueous solution of the first step at a speed of 2 mL / h with a micro-syringe pump, and then stirred overnight;
[0076]Under the condition of magnetic stirring, inject 40 mL of the chitin solution at a constant speed of 0.5 mL / min with a micro-syringe pump,...
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