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Sustained release drug nanofibers and preparation method thereof

A technology of nanofibers and slow-release drugs, which is applied in the direction of pharmaceutical formulations, drug delivery, and medical preparations of non-active ingredients. It can solve problems such as unsatisfactory drugs, and achieve improved encapsulation efficiency, maintenance of biological activity, and long-term stable release. Effect

Active Publication Date: 2018-12-11
TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional method is to coat the surface of the drug with a slow-release shell, through which the release period of the drug can be extended for several days, but even the extended release period still cannot meet the weeks or even several days required for the drug to work. cycle of month

Method used

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  • Sustained release drug nanofibers and preparation method thereof
  • Sustained release drug nanofibers and preparation method thereof

Examples

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preparation example Construction

[0045] see figure 2 , the embodiment of the present invention also provides a preparation method of the sustained-release drug nanofibers, comprising the following steps:

[0046] S100, providing the drug-loaded nanospheres 11;

[0047] S200, mixing the drug-loaded nano-microspheres 11 and the core sustained-release material in a solvent to obtain a core spinning solution;

[0048] S300, prepare a plurality of shell spinning solutions respectively, each shell spinning solution includes a solution of the material of the nanofiber slow-release layer 20;

[0049] S400, performing coaxial electrospinning on the core layer spinning solution and the plurality of shell layer spinning solutions with a coaxial spinning needle, and the coaxial spinning needle has a plurality of coaxially arranged liquid outlets , for simultaneously outputting the core layer spinning solution and the plurality of shell layer spinning solutions respectively.

[0050] The drug-loaded nano-microspheres ...

Embodiment 1

[0063] Example 1 Preparation of drug-loaded nanospheres 11

[0064] This embodiment is used to prepare drug-loaded nanospheres 11 with two layers of sustained-release layers of nanospheres. The sustained-release layers of nanospheres are chitin layer and BSA layer respectively.

[0065] Mix 80 μg of BMP-2 and 100 mg of BSA, and dissolve with 10 mL of deionized water under slight magnetic stirring to obtain a drug-loaded BSA aqueous solution;

[0066] Add 50mg of chitin to 50mL of 0.5wt% acetic acid solution, stir magnetically, and prepare a 1mg / mL chitin solution;

[0067] Under the condition of magnetic stirring, a total of 40 mL of ethanol was uniformly injected into the drug-loaded BSA aqueous solution in the first step at a rate of 2 mL / h with a micro-injection pump, and then stirred overnight;

[0068] Under the condition of magnetic stirring, inject 40 mL of the chitin solution prepared in the second step at a constant speed of 0.5 mL / min with a micro-injection pump, an...

Embodiment 2

[0071] Example 2 Preparation of drug-loaded nanospheres 11

[0072] The difference between this example and Example 1 is that the sustained-release layer of the drug-loaded nanospheres 11 consists of three layers, namely a chitin layer, a BSA layer and a chitin layer.

[0073] Mix 80 μg of BMP-2 and 100 mg of BSA, and dissolve with 10 mL of deionized water under slight magnetic stirring to obtain a drug-loaded BSA aqueous solution;

[0074] Add 50mg of chitin to 50mL of 0.5wt% acetic acid solution, stir magnetically, and prepare a 1mg / mL chitin solution;

[0075] Under the condition of magnetic stirring, a total of 40 mL of ethanol was uniformly injected into the drug-loaded BSA aqueous solution in the first step at a rate of 2 mL / h with a micro-injection pump, and then stirred overnight;

[0076]Under the condition of magnetic stirring, inject 40 mL of the chitin solution at a constant speed of 0.5 mL / min with a micro-injection pump, and continue to stir for 8 hours to prepa...

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Abstract

The invention discloses sustained release drug nanofibers which are of a core-shell structure and comprise multiple nanofiber sustained release layers and nanofiber cores; each nanofiber core is wrapped with multiple nanofiber sustained release layers and comprises a mixed drug-loaded nanoparticle and a core layer sustained release layer; and the mixed drug-loaded nanoparticle is of the core-shellstructure and comprises an active drug and nanoparticle sustained release layers wrapping the active drug. The invention also discloses a preparation method of the sustained release drug nanofibers.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to sustained-release drug nanofibers and a preparation method thereof. Background technique [0002] Some drug treatments for diseases require a certain cycle, such as bone cell repair, periodontitis, etc. If it is directly injected into the body, the drug will be rapidly dispersed and degraded in a short period of time, such as within a day, and cannot play a long-term role in promoting recovery. Therefore, how to maintain and prolong the biological activity of the drug in the body environment is the key to the drug's real clinical effect. In order to solve the problem of high-efficiency application of drugs, drug controlled release technology can be introduced. That is, the use of biodegradable polymer materials to load drugs, quantitative and sustained release to seed cells, so that the drug can maintain activity for a long time, which is also an important factor in the evaluation o...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/51A61K9/52A61K31/192A61K31/4164A61K31/65A61K38/18A61K47/34A61K47/36A61K47/42
CPCA61K9/0092A61K9/5161A61K9/5169A61K31/192A61K31/4164A61K31/65A61K38/1825A61K38/1841A61K38/1858A61K38/1866A61K38/1875A61K47/34A61K47/36A61K47/42
Inventor 张洪玉王毅
Owner TSINGHUA UNIV
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