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Hirudo injection preparation technology

A technology for preparation of injection and leech extract, which is applied in the field of medicine, can solve problems such as turbidity of injection, poor product clarity, and affect product quality, and achieve the effects of improving dispersion effect, excellent clarity, and improving clarity

Pending Publication Date: 2018-12-11
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of leeches are proteins, polypeptides, trace elements and fatty acid elements, etc. Currently, decoctions, capsules, tablets, pills, oral liquids, etc. are often used in clinical practice, and seldom used as injections in clinical practice. Some leeches are currently on the market Injection, but due to the relatively simple preparation process, the clarity of the prepared product is not good. At the same time, when it is stored under low temperature conditions in winter, it is easy to precipitate small white spots, making the injection cloudy, which seriously affects the quality of the product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of leech injection preparation technology, it specifically comprises the following steps:

[0026] 1) Preparation of raw materials: Weigh 1 part of leech extract, 0.9 parts of osmotic pressure regulator and 62 parts of water for injection according to parts by weight, and set aside;

[0027] Wherein, the preparation method of the leech extract is to take the dried leech and grind it into a 200-mesh powder, add 12 times the volume of 0.9% physiological saline at room temperature to soak for 48 hours, then stir at a rate of 800r / min for 30min, and then - Freeze at 20°C for 28 hours, after slow freezing, centrifuge at a rate of 3000r / min for 10 minutes, collect the supernatant and filter it with a 0.1 μm filter membrane to obtain the leech extract; the osmotic pressure regulator is manna Alcohol, sodium chloride and water for injection are mixed according to the ratio of 1:6:13 by weight;

[0028] 2) Preparation of pH regulator: Weigh maleic acid and add an appropr...

Embodiment 2

[0036] A kind of leech injection preparation technology, it specifically comprises the following steps:

[0037] 1) Preparation of raw materials: Weigh 1.5 parts of leech extract, 1.1 parts of osmotic pressure regulator and 70 parts of water for injection according to parts by weight, and set aside;

[0038] Wherein, the preparation method of the leech extract is to take the dried leech and grind it into a 200-mesh powder, add 12 times the volume of 0.9% physiological saline at room temperature to soak for 48 hours, then stir at a rate of 800r / min for 30min, and then - Freeze at 20°C for 28 hours, after slow freezing, centrifuge at a rate of 3000r / min for 10 minutes, collect the supernatant and filter it with a 0.1 μm filter membrane to obtain the leech extract; the osmotic pressure regulator is manna Alcohol, sodium chloride and water for injection are mixed according to the ratio of 1:6:13 by weight;

[0039] 2) Preparation of pH regulator: Weigh maleic acid and add an appr...

Embodiment 3

[0047] A kind of leech injection preparation technology, it specifically comprises the following steps:

[0048] 1) Raw material preparation: Weigh 1.25 parts of leech extract, 1 part of osmotic pressure regulator and 66 parts of water for injection according to parts by weight, and set aside;

[0049] Wherein, the preparation method of the leech extract is to take the dried leech and grind it into a 200-mesh powder, add 12 times the volume of 0.9% physiological saline at room temperature to soak for 48 hours, then stir at a rate of 800r / min for 30min, and then - Freeze at 20°C for 28 hours, after slow freezing, centrifuge at a rate of 3000r / min for 10 minutes, collect the supernatant and filter it with a 0.1 μm filter membrane to obtain the leech extract; the osmotic pressure regulator is manna Alcohol, sodium chloride and water for injection are mixed according to the ratio of 1:6:13 by weight;

[0050] 2) Preparation of pH regulator: Weigh maleic acid and add an appropriat...

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PUM

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Abstract

The invention discloses a hirudo injection preparation technology. The hirudo injection preparation technology comprises the following steps: 1) preparing a raw material; 2) preparing a pH modifier; 3) vacuum-processing; 4) ultrasonic-processing; 5) regulating a pH; 6) filtering; and 7) sterilizing. Hirudo injection prepared by using the technology has excellent clarity. Through multiple times ofthe vacuum-processing, oxygen content in hirudo extracting solution is reduced, the clarity of the hirudo injection is advantageously improved, and the hirudo injection does not easily become turbid while stored in a low temperature. At the same time, through the ultrasonic-processing, the dispersion effect of a material is effectively improved, and the clarity of the hirudo extracting solution isadvantageously improved. A pH value is further regulated through maleic acid solution and disodium hydrogen phosphate solution, the clarity of a product is advantageously improved, the product does not easily become turbid while stored in the low temperature, and the product has extensive market prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation process of leech injection. Background technique [0002] Leech, commonly known as leech, is an invertebrate mollusk without a skeleton structure. It was first recorded in "Shen Nong's Herbal Classic". Abdominal pain, bruises and other symptoms. The main components of leeches are proteins, polypeptides, trace elements and fatty acid elements, etc. Currently, decoctions, capsules, tablets, pills, oral liquids, etc. are often used in clinical practice, and seldom used as injections in clinical practice. Some leeches are currently on the market Injection, but due to the relatively simple preparation process, the clarity of the prepared product is not good. At the same time, when stored under low temperature conditions in winter, it is easy to separate out small white spots and make the injection cloudy, which seriously affects the quality of the product. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/62A61K9/08A61K47/12A61K47/02A61P35/00A61P9/10A61P9/12A61P29/00
CPCA61K47/02A61K47/12A61P9/10A61P9/12A61P29/00A61P35/00A61K9/0019A61K9/08A61K35/62
Inventor 胡跃强唐农陈炜
Owner GUANGXI UNIV OF CHINESE MEDICINE