Conjugated polymer, synthesis method and method for detecting etimicin concentration by using conjugated polymer

A technology of conjugated polymers and etimicin, which is applied in measuring devices, color/spectral characteristic measurements, instruments, etc., to achieve good extinction coefficient, good dispersion, and improved sensitivity

Inactive Publication Date: 2018-12-11
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing conjugated polymers and detection methods for th

Method used

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  • Conjugated polymer, synthesis method and method for detecting etimicin concentration by using conjugated polymer
  • Conjugated polymer, synthesis method and method for detecting etimicin concentration by using conjugated polymer
  • Conjugated polymer, synthesis method and method for detecting etimicin concentration by using conjugated polymer

Examples

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preparation example Construction

[0086] The preparation method reference example 4 of silver nanoparticle solution

[0087] Add 1.2 mL of 0.02 mol / L silver nitrate solution and 0.32 mL of 0.25 mol / L sodium citrate solution into 100 mL of water at the same time, stir and mix well, then add the newly prepared 0.96 mL 0.25 mol / L sodium borohydride solution in one go, Continue to stir for 30 minutes, and it's done.

[0088] like figure 1 As shown, the silver nanoparticle solution obtained in this reference example contains uniformly dispersed silver nanoparticles with a particle size of 10-15 nm.

[0089] like figure 2 Shown, by the analysis of particle diameter distribution, in this reference example gained silver nanoparticle solution, the particle diameter of silver nanoparticle is mainly distributed in 10~15nm, and figure 1 unanimous.

[0090] like image 3 As shown, the silver nanocomposites were formed after adding the conjugated polymer to the silver nanoparticle solution.

[0091] like Figure 4 A...

Embodiment 1

[0098] Conjugated polymers:

[0099] Its general chemical structure is:

[0100] ,

[0101] Among them, n=100-150, and the molecular weight is 52000-78000 g / mol.

[0102] Synthesis of conjugated polymers:

[0103] (1) To a mixed solution of 5mL water, 7.5mL (7.11g) dimethylformamide and 2.5mL (1.79g) diisopropylamine, under the protection of nitrogen atmosphere, add 0.025g of 2,6-di Ethynylpyridine, 0.131g reference example 3 obtained 1,4-diiodo-2,5-dipropoxysodium benzene and 0.03g catalyst (reference example 1 obtained tetrakistriphenylphosphine palladium and cuprous iodide The mass ratio is 6:1 mixture), heated at 65°C for 30h, cooled to room temperature, filtered, washed the resulting solid with water to obtain conjugated polymer 1, and at 60°C, the filtrate was spin-concentrated 10h, until viscous, 0.2mL concentrated solution was obtained;

[0104] (2) Add 0.2mL of the concentrated solution obtained in step (1) to 4mL of organic mixed solvent (mixed solvent with a ...

Embodiment 2

[0106] Conjugated polymers:

[0107] ,

[0108] Among them, n=100-110, and the molecular weight is 52000-57000 g / mol.

[0109] Synthetic method of conjugated polymer:

[0110] (1) Add 0.015 g of 2,6-diethynyl obtained in Reference Example 2 to a mixed solution of 4 mL of water, 6 mL (5.69 g) of dimethylformamide and 2 mL (1.52 g) of diisopropylamine under the protection of a nitrogen atmosphere Pyridine, 0.08g reference example 3 gained 1,4-diiodo-2,5-dipropoxy sodium benzene and 0.018g catalyst (reference example 1 gained tetrakistriphenylphosphine palladium and cuprous iodide mass ratio 5:1 mixture), heated at 60°C for 36h, cooled to room temperature, filtered, and washed the solid with water to obtain conjugated polymer 2, and at 70°C, spin-concentrated the filtrate for 8h to Viscous, 0.3mL concentrate;

[0111] (2) Add 0.3mL of the concentrated solution obtained in step (1) to 4mL of an organic mixed solvent (mixed solvent with a volume ratio of acetone and ether at ...

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Abstract

The invention discloses a conjugated polymer and a method for synthesizing the conjugated polymer. The detection method is as follows: (1) adding an aqueous solution of a conjugated polymer and a nanosilver solution to a buffer solution, stirring and reacting, standing, and measuring the fluorescence intensity; (2) adding a solution containing the etimicin to be tested, stirring and reacting, standing, and measuring the fluorescence intensity or absorbance; and (3) calculating the molar concentration of etimicin. The conjugated polymer of the invention can be adsorbed on the surface of the silver nanoparticle in a non-covalent manner to realize fluorescence and colorimetric detection; and is also well soluble in water and an organic solvent. The synthesis method provided by the inventionis simple in operation, low in cost and suitable for the industrial production. The detection method provided by the invention combines the conjugated polymer with the silver nano particles to form anew nano-composite system, which obviously improves the sensitivity of the detection for etimicin, is simple and easy, and has accurate detection, rapidness, sensitivity, good detection linear and good selectivity.

Description

technical field [0001] The invention specifically relates to a conjugated polymer, a synthesis method and a method for detecting the concentration of etimicin by using the conjugated polymer. Background technique [0002] Etimicin (Etimicin, ETM) is a new anti-infective drug developed by my country (Chin. J. Antibiot., 1995, 20: 401-406). Extensive pharmacological, toxicological, pharmacodynamic and clinical studies have shown that: ETM is a new aminoglycoside antibiotic with low toxicity and definite curative effect. Etimicin has an excellent curative effect in the application of diarrhea, peritonitis, enteritis and other intestinal infectious diseases caused by sensitive bacteria in adolescents and children, cleaning the intestinal cavity before surgery, and gastritis related to Helicobacter pylori (CN106491515A, CN106727294A). The drug has the characteristics of high efficiency, safety, spectrum, antibacterial, and drug resistance, low adverse reactions, and good resista...

Claims

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Application Information

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IPC IPC(8): C08G61/12G01N21/64G01N21/33
CPCC08G61/122C08G2261/124C08G2261/228C08G2261/312C08G2261/3221C08G2261/3328C08G2261/344C08G2261/354G01N21/33G01N21/6428G01N2021/6432
Inventor 黄红梅张艳然肖毅朱曦曦杜慧凤何晓晓张友玉
Owner HUNAN NORMAL UNIVERSITY
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