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Liposome of bionic vernix caseosa and preparing method and application thereof

A technology of biomimetic vernix and liposome, which is applied in the field of preparation and liposome of biomimetic vernix, which can solve the social and ethical controversy of vernix, the inapplicability of vernix products from different sources, and the reduction of the use effect of biomimetic vernix, etc.

Inactive Publication Date: 2018-12-14
SHANGHAI CHILDRENS NUTRITION CENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are the following problems in the direct use of vernix: 1) the source is scarce, and only white vernix that has not completely disappeared will remain on some newborn or premature babies, and the vernix carried by some babies will dissolve by itself before birth; 2) individual The difference may cause the inapplicability of vernix products from different sources, so the natural vernix carried by the fetus itself cannot be used directly; 3) The use of vernix from babies will cause social and ethical controversy
However, on the one hand, the addition of active substances during use will inevitably produce certain side effects; on the other hand, with the loss of activity of the active substances during storage, the use effect of bionic vernix will be reduced.

Method used

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  • Liposome of bionic vernix caseosa and preparing method and application thereof
  • Liposome of bionic vernix caseosa and preparing method and application thereof
  • Liposome of bionic vernix caseosa and preparing method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045]A liposome of bionic vernix, comprising the following first component and second component, wherein, the first component includes by weight percentage:

[0046] Squalane 45%

[0047] Hydrogenated Lecithin 24%

[0048] Glutamate 25%

[0049] Lysozyme 6%;

[0050] The second group is cholesterol.

[0051] The weight ratio of the first component to the second component is 1:2.

[0052] Its preparation method comprises the following steps:

[0053] 1. Prepare materials: Weigh 10g of the above-mentioned first component by weight percentage, add it to 20g of cholesterol, mix well, then add 30g of ether, and stir the above-mentioned mixture at a temperature of 25°C to make a mixed solution A; prepare the disodium hydrogen phosphate aqueous solution of 0.3g / L;

[0054] 2. Add the mixed solution A to 180g of disodium hydrogen phosphate water-soluble B, emulsify, control the homogenization speed to 8000rpm, the homogenization temperature to 10°C, and the homogenization time ...

Embodiment 2

[0058] A liposome of bionic vernix, comprising the following first component and second component, wherein, the first component includes by weight percentage:

[0059] Squalane 35%;

[0060] Hydrogenated Lecithin 24%;

[0061] Glutamate 35%;

[0062] Lysozyme 6%;

[0063] The second group consists of cholesterol.

[0064] The weight ratio of the first component to the second component is 1:2.

[0065] Its preparation method comprises the following steps:

[0066] 1. Prepare materials: Weigh 10g of the above first component by weight percentage, add it to 20g of cholesterol, mix well, then add 30g of ether, and stir the above mixture at a temperature of 55°C to make a mixed solution A; prepare the disodium hydrogen phosphate aqueous solution of 0.3g / L;

[0067] 2. Add the mixed solution A to 180g of disodium hydrogen phosphate water-soluble B, emulsify, control the homogenization speed to 1000rpm, the homogenization temperature to 60°C, and the homogenization time to 25mi...

Embodiment 3

[0071] A liposome of biomimetic vernix, comprising a first component and a second component, wherein, the first component comprises by weight percentage:

[0072] Squalane 35%;

[0073] Hydrogenated Lecithin 29%;

[0074] Serine 30%;

[0075] Lysozyme 6%;

[0076] The second component is soybean lecithin, and the weight ratio of the first component to the second component is 1:4.

[0077] Its preparation method comprises the following steps:

[0078] 1. Preparation of materials: Weigh 10g of the above-mentioned first component by weight percentage, add it to 40g of soybean lecithin, mix well, then add 12g of ethanol, and stir the above-mentioned mixture uniformly at a temperature of 70°C to obtain Mix solution A; prepare glycerin aqueous solution B, the weight ratio of glycerin: deionized water is 5:4;

[0079] 2. Add the mixed solution A to 350 g of glycerol aqueous solution B, emulsify, homogenize at a temperature of 30° C., and homogenize for 25 minutes to obtain a nan...

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Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a liposome of bionic vernix caseosa and a preparing method and application thereof. The liposome includes squalane, hydrogenated lecithin, antibacterial peptide and amino acids, and is prepared through emulsification to cover the antibacterial peptide within the inner layer of the liposome, thus improving stability of the antibacterial peptide and other activated proteins. When the liposome prepared by the method is applied onto skin, the absorption rate of activated compounds can be increased, thus reducingthe dosage of the activated compounds and reducing side effects of the activated compounds on human skin. In addition, the liposome prepared by the method has antibacterial, anti-infection, pH buffering and skin epidermal barrier maintaining functions, and can be widely applied in various skincare products in the field of cosmetics.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a liposome of bionic vernix, a preparation method and an application. Background technique [0002] The stratum corneum of the baby's skin is very thin, the skin is delicate, and the baby's sweat glands are exuberant, the skin is not fully developed, and the ability to control acid and alkali is poor. The skin can only be protected by an acidic protective film on the surface of the skin to prevent bacterial infection. If it is stimulated by the outside world, it may cause allergies, redness and swelling. [0003] Vernix is ​​a layer of natural biological protective film covering the surface of the fetal skin. It begins to appear on the back and eyebrows of the fetus at the 17th week of pregnancy, and then covers the whole body from back to front and from top to bottom. Vernix creates a dry and suitable environment for fetal growth and development in the amniotic fl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61K8/64A61K8/55A61K8/49A61K8/44A61K8/31A61K8/14A61Q17/00A61Q19/00A61Q19/10A61Q5/02
CPCA61K8/14A61K8/31A61K8/44A61K8/442A61K8/4913A61K8/553A61K8/64A61K8/66A61Q5/02A61Q17/005A61Q19/00A61Q19/005A61Q19/10
Inventor 邓文峰
Owner SHANGHAI CHILDRENS NUTRITION CENT CO LTD
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