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Pharmaceutical composition containing levofloxacin hydrochloride

A technology of levofloxacin hydrochloride and a composition, which is applied in the field of human pharmaceutical preparations to achieve the effects of improving the bactericidal effect, broadening the scope of application, and significantly synergizing the antibacterial effect.

Inactive Publication Date: 2018-12-18
王伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combination of Galla galla and antibiotics has not been found yet. In order to better exert the antibacterial effect of anti-infective traditional Chinese medicine and reflect the advantages of combining Chinese and Western medicines for antibacterial, the inventor tried to study the combined use of ofloxacin and Galla galla extract.

Method used

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  • Pharmaceutical composition containing levofloxacin hydrochloride
  • Pharmaceutical composition containing levofloxacin hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The commercially available levofloxacin hydrochloride raw material medicine and the ethanol extract of Galla Chinensis were mixed in a weight ratio of 1:4 to prepare a pharmaceutical composition.

[0015] Among them, the gallnut extract is made according to the following method:

[0016] First, the commercially available gallnut is made into 50g gallnut slices according to the usual method. After simmering, it is made into 200mL decoction (25% gallnut decoction). The filtrate is concentrated to 1:1~1:2, and an appropriate amount of high-concentration ethanol is added. The amount of alcohol reaches 60% to 70%. Refrigerate, filter, and recover ethanol from the filtrate and concentrate appropriately. Refrigerate for 4-8h or overnight to filter out the precipitated fat-soluble components. Add ethanol to the filtrate to make the alcohol content to 80%-85%. Refrigerate, filter, and recover ethanol from the filtrate. , Concentrate, and dry the concentrated solution in a 37°C incub...

Embodiment 2

[0018] The commercially available levofloxacin hydrochloride raw material medicine and the ethanol extract of Galla Chinensis were mixed in a weight ratio of 1:6 to prepare a pharmaceutical composition.

[0019] Among them, the gallnut extract is made according to the following method:

[0020] First, the commercially available gallnut is made into 50g gallnut slices according to the usual method. After simmering, it is made into 200mL decoction (25% gallnut decoction). The filtrate is concentrated to 1:1~1:2, and an appropriate amount of high-concentration ethanol is added. The amount of alcohol reaches 60% to 70%. Refrigerate, filter, and recover ethanol from the filtrate and concentrate appropriately. Refrigerate for 4-8h or overnight to filter out the precipitated fat-soluble components. Add ethanol to the filtrate to make the alcohol content to 80%-85%. Refrigerate, filter, and recover ethanol from the filtrate. , Concentrate, and dry the concentrated solution in a 37°C incub...

Embodiment 3

[0022] The commercially available levofloxacin hydrochloride raw material medicine and the ethanol extract of Galla Chinensis were mixed in a weight ratio of 2:5 to prepare a pharmaceutical composition.

[0023] Among them, the gallnut extract is made according to the following method:

[0024] First, the commercially available gallnut is made into 50g gallnut slices according to the usual method. After simmering, it is made into 200mL decoction (25% gallnut decoction). The filtrate is concentrated to 1:1~1:2, and an appropriate amount of high-concentration ethanol is added. The amount of alcohol reaches 60% to 70%. Refrigerate, filter, and recover ethanol from the filtrate and concentrate appropriately. Refrigerate for 4-8h or overnight to filter out the precipitated fat-soluble components. Add ethanol to the filtrate to make the alcohol content to 80%-85%. Refrigerate, filter, and recover ethanol from the filtrate. , Concentrate, and dry the concentrated solution in a 37°C incub...

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Abstract

The invention provides a pharmaceutical composition containing levofloxacin hydrochloride. The pharmaceutical composition is characterized by being prepared from the following components in parts by mass: 1 to 2 parts of the levofloxacin hydrochloride and 4 to 6 parts of Chinese gall extract. An antibacterial composite medicine provided by the invention has a remarkable synergistic antibacterial effect and the prepared pharmaceutical composition keeps original broad-spectrum antibacterial performance and also has a good inhibition effect on anaerobic bacteria, so that an application range of the levofloxacin hydrochloride is widened.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations for human use, and particularly relates to an antibacterial pharmaceutical composition containing levofloxacin. Background technique [0002] Levofloxacin hydrochloride is a third-generation quinolone antibiotic. It has the characteristics of broad antibacterial spectrum and strong antibacterial effect. It has a strong inhibitory effect on most Enterobacteriaceae bacteria. The main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. However, research results in recent years have shown that with the large-scale use of fluoroquinolones in clinical practice, the resistance of Escherichia coli and Klebsiella pneumoniae to them has risen rapidly, showing obvious cross-resistance, leading to their clinical application. The application is greatly restricted. Modern studies have shown that Chinese medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P31/04A61K31/5383
CPCA61P31/04A61K31/5383A61K35/63A61K2300/00
Inventor 王伟
Owner 王伟