Bactericide and application thereof
A technology of fungicides and uses, applied in the agricultural field, can solve the problems of crop yield reduction and agricultural losses caused by plant diseases, and achieve the effect of good bactericidal activity
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Embodiment 1
[0043] The synthesis of embodiment 1 compound A-1:
[0044]
[0045] In the 1000 milliliter there-necked flask, add 300 milliliters of acetic anhydride, 200 milliliters of acetic acid, 15.8 grams (0.1mol) of 2,2-difluorobenzo[d][1,3]dioxane shown in formula M-01, cooling To 10°C, slowly add dropwise a mixture of 9.69 grams (0.1mol) of 65% nitric acid and 20.6 grams of 98% sulfuric acid, and keep the reaction at 10°C for 90 minutes, add water and dichloromethane to separate the liquid, and wash the organic layer with water until neutral , concentrated to dryness, separated by silica gel column chromatography, eluting with petroleum ether:ethyl acetate=10:1 (volume ratio), to obtain 2,2-difluoro-4-nitrobenzo[ d] [1,3]dioxane 5.8 g, yield 28.57%.
[0046] The 2,2-difluoro-4-nitrobenzo[d][1,3]dioxane represented by the obtained M-02 was detected by mass spectrometry, and the m / e of the product was obtained: 203.
[0047] Add 200 milliliters of methanol, 5 grams of 5% Pd / C (dr...
Embodiment 2
[0057] Embodiment 2 Synthesis of other part of compounds of the present invention
[0058] Referring to the synthesis of compound A-1, just replace M-01 and M-05 according to the needs, synthesize the following compounds, and perform mass spectrometry detection on the synthesized compounds. The results are shown in the following table:
[0059]
[0060]
[0061]
Embodiment 3
[0062] The preparation of embodiment 3 wettable powders:
[0063] A total of 18 kinds of wettable powders were prepared, and the components of the prepared wettable powders are listed below, wherein the percentages are weight percentages.
[0064]
[0065]
[0066] The preparation method of wettable powder is illustrated as follows with the code name of wettable powder KS-1:
[0067] Active ingredient A-1 of 25% by weight, sodium lauryl sulfate of 2% by weight, sodium lignosulfonate of 3% by weight, tetrabutylammonium bromide of 0.2% by weight, naphthalenesulfonic acid of 2% by weight The formaldehyde condensate and 67.8% of light calcium carbonate are fully mixed and pulverized by an ultra-fine pulverizer to obtain a 25% wettable powder.
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