Cefepime sulfate injection and preparation method thereof

A technology of cefquinoxime sulfate and injection, which is applied in the field of cefquinome sulfate injection and preparation thereof, can solve problems such as short action time, and achieve the effects of less irritation, high safety and good stability

Inactive Publication Date: 2018-12-21
遂宁市中通实业集团动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing cefquinone sulfate bladder injection has a short action time and needs to be injected once a day for consecutive days. Now, a long-acting long-acting solution has been developed to reduce the frequency of medication, reduce the stress response of animals, and provide convenience for farmers to meet market needs. Cefquine Sulfate Injection, after intramuscular injection, slowly releases the blood drug concentration, which effectively reduces the drug's toxic and side effects and prolongs the effective time of the drug in the body

Method used

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  • Cefepime sulfate injection and preparation method thereof
  • Cefepime sulfate injection and preparation method thereof
  • Cefepime sulfate injection and preparation method thereof

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Embodiment Construction

[0022] The present invention will be described in further detail below through specific examples. The following examples can enable those skilled in the art to understand the present invention more comprehensively, but do not limit the present invention in any way.

[0023] 1. Equipment, drugs and reagents

[0024] 1Main production equipment

[0025]

[0026] 2. Main medicines and reagents

[0027] Cefquinone sulfate (Shandong Lukang Like Pharmaceutical Co., Ltd., batch number: 1111001 dry product content 98.6%;

[0028] Span-60 (Aladdin reagent pharmaceutical grade);

[0029] Hydrogenated castor oil (Tongliao Chemical Plant pharmaceutical grade batch number: 1112015);

[0030] Soybean oil for injection (Zhejiang Tianyushan Medicinal Oil Co., Ltd. injection grade batch number: 1111002);

[0031] BHT (Sinopharm Chemical Reagent Analytical Pure);

[0032] Ethyl oleate (Jiangxi Alpha Gaoke Pharmaceutical Co., Ltd. pharmaceutical grade batch number: 1112027)

[0033] Cott...

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Abstract

The invention belongs to the field of veterinary drugs and particularly relates to cefepime sulfate injection. The cefepime sulfate injection, counted by every 1000mL, is prepared from the following components: 15 to 30g of cefquinome sulfate, 300 to 500 mL of a solvent, 15 to 30g of a surfactant, 10 to 20g of an antioxidant, 3 to 7g of a pH modifier and the balance of solvent for injection. The cefepime sulfate suspension injection prepared by the invention has the advantages of high safety, good stability and small irritation when being used for intramuscular injection.

Description

technical field [0001] The invention relates to a cefquinome sulfate injection and a preparation method thereof. Background technique [0002] Cefquinoxime is the fourth-generation cephalosporin antibiotic for animals. It is a broad-spectrum and highly effective cephalosporin antibiotic. Compared with the third-generation cephalosporin, it has a wider antibacterial spectrum and stronger bactericidal effect. Its intrinsic antibacterial activity is stronger than that of the first three generations of cephalosporins. Compared with the first three generations of cephalosporins, the fourth generation of cephalosporins requires less dosage, has strong sensitivity to treating bacteria, has a long blood half-life, and has no nephrotoxicity. It has a strong killing effect on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteriaceae (Escherichia coli, Salmonella, Klebsiella, Serratia marcescens). It has a significant effect on respiratory diseases (pleuropneumo...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/44A61P31/04
CPCA61K9/0019A61K9/10A61K31/546A61K47/44A61P31/04
Inventor 郑伯均
Owner 遂宁市中通实业集团动物药业有限公司
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