Paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution and preparation method thereof

The technology of paracetamol renin oral liquid and diphenhydramine hydrochloride is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. , less variety, etc.

Active Publication Date: 2018-12-21
YUNNAN DATANG HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention is a kind of new medicine developed aiming at the disadvantages of current cold medicines for children in my country, such as few varieties, few formulations

Method used

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  • Paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution and preparation method thereof
  • Paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution and preparation method thereof
  • Paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 200 g of propylene glycol and put it in a container, add 1.0 g of xanthan gum, stir to make it evenly dispersed, and obtain solution 1, which is set aside;

[0047] Take the above solution 1, add 50g of sucralose, 1.0g of anhydrous citric acid, 0.6g of disodium edetate, 2.0g of propyl gallate, 1.7g of sodium benzoate, 0.4ml of strawberry essence, 30mg of brilliant blue, add water A certain amount, stirred to dissolve, to obtain solution 2, set aside;

[0048] Add 40g of paracetamol, 1.0g of diphenhydramine hydrochloride, 0.3g of phenylephrine hydrochloride to the above solution 2, add water to 1000ml, stir until dissolved, filter with 0.35um microporous membrane, filter with 0.03-0.08 Degas under reduced pressure at kpa for 20 minutes, fill it, and get ready.

Embodiment 2

[0050] Take 2 / 3 of the prepared amount of water, put it in a clean container, add 1g of xanthan gum under stirring, until it swells fully, and obtain solution 1, which is set aside;

[0051] Add glycerin 200g, sorbitol 50g, sodium citrate 1.0g, edetate disodium 0.3g, propyl gallate 2.0g, sodium benzoate 2.0, strawberry essence 0.5ml, allura red 3.0mg to solution 1 in sequence, and stir to make It dissolves to obtain solution 2, which is set aside;

[0052] Add 31g of acetaminophen, 1.1g of diphenhydramine hydrochloride, and 0.7g of phenylephrine hydrochloride in sequence to the above solution 2, add water to 1000ml, stir until dissolved, and filter with a 0.45um microporous membrane, 0.03-0.08kpa Degas under reduced pressure for 30 minutes, fill it, and get ready.

Embodiment 3

[0054] Take 300g of propylene glycol, put it in a certain amount of container, add 1.1g of xanthan gum, stir to make it evenly dispersed, and obtain solution 1, set aside;

[0055] Weigh 200g of glycerin, add it to the above solution 1, then add 100g of sorbitol, 2.5g of sucralose, 1.9g of anhydrous citric acid, 0.73g of citric acid, 0.5g of disodium edetate, and propyl gallate 2.18g, 2.25g of sodium benzoate, 1.0ml of strawberry essence, 0.5ml of grape essence, 37.9mg of brilliant blue, 2.7mg of allura red, add a certain amount of water, stir to dissolve, and obtain solution 2, set aside;

[0056] Add 32.5g of paracetamol, 1.25g of diphenhydramine hydrochloride, and 0.5g of phenylephrine hydrochloride to the above solution 2 in sequence, add water to 1000ml, stir until dissolved, and filter with a 0.45um microporous membrane, 0.03-0.08 Degas under reduced pressure at kpa for 60 minutes, fill it, and get ready.

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Abstract

The invention discloses a paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution and a preparation method thereof. The paracetamol, diphenhydramine hydrochloride andphenylephrine hydrochloride oral solution is a novel medicine developed for overcoming the defects that the existing cold-treating medicines for children in China have few varieties, few dosage forms,too large dosage, incomplete specifications, difficultly accepted taste and the like; and the paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution can treat cold-induced symptoms such as headache, mild pain, pain, nasal congestion, a runny nose, sneezing, cough, fever and a sore throat. The paracetamol, diphenhydramine hydrochloride and phenylephrine hydrochloride oral solution is a fruity oral liquid preparation mainly for 6-12-year-old children with a cold.

Description

technical field [0001] The invention belongs to the technical field of drug research and development, and in particular relates to acetaminophen lamin renin oral liquid and a preparation method thereof. Background technique [0002] Cold, commonly known as "cold", is the most common disease in acute upper respiratory tract viral infection, mostly self-limiting, but with a high incidence rate, affecting a wide range of people and a large number of people, and can cause various complications. [0003] Childhood cold is exactly the cold disease that people suffer from in childhood. Children's colds are different from adults' colds. It is mainly because children's body resistance is very weak, and the probability of infection with viruses is higher than that of adults. [0004] Cold medicines for children refer to special cold medicines for minors under the age of 14. As a special group of drug users, children have unique physiological and drug characteristics, and their abili...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/135A61K31/137A61K9/08A61P11/00A61P31/12A61P29/00
CPCA61K9/0053A61K31/135A61K31/137A61K31/167A61K47/26A61K47/36A61P11/00A61P29/00A61P31/12A61K2300/00
Inventor 朱光荣
Owner YUNNAN DATANG HANFANG PHARMA
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