A kind of earthworm syrup nano-silver hydrogel patch and preparation method thereof

A technology of hydrogel patch and nano-silver sol is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., and can solve the problems of easily polluted clothes, unsuitable storage of Dilong syrup, inconvenient use, etc. The effect of improving drug efficacy and quality, efficient and safe drug resistance, and high drug utilization rate

Active Publication Date: 2021-11-26
SICHUAN AGRI UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0009] In view of this, the present invention aims at the fact that the traditional earthworm syrup is not suitable for storage, it is easy to deteriorate, the quality is not easy to control, it is inconvenient to use, it is easy to contaminate clothes, and it cannot play the role of antibacterial and anti-inflammatory, and nano silver cannot directly act on burns and sores. problem, a kind of earthworm syrup nano-silver hydrogel patch and its preparation method are provided

Method used

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  • A kind of earthworm syrup nano-silver hydrogel patch and preparation method thereof
  • A kind of earthworm syrup nano-silver hydrogel patch and preparation method thereof
  • A kind of earthworm syrup nano-silver hydrogel patch and preparation method thereof

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preparation example Construction

[0032] The invention discloses a preparation method of earthworm syrup nano-silver hydrogel patch, which comprises the following steps:

[0033] Step 1. Prepare earthworm syrup: soak earthworm in clean water to wash the soil, take it out and put it on absorbent paper to absorb the water, and obtain pretreated earthworm, mix the pretreated earthworm with sugar, and , the mass ratio of pretreated earthworm to white sugar is 1:0.6-1:1.6, and after standing for 1.5-2.5h, earthworm will gradually precipitate body fluid and shrink; the mixture is centrifuged and filtered for 2-3 times, and the leachate is taken That is earthworm syrup;

[0034] Step 2. Preparation of nano-silver: put nano-silver in distilled water, and ultrasonically treat it for 5-15 minutes to obtain nano-silver sol; wherein, the mass-volume ratio (g / L) of nano-silver to distilled water is 1:20-8:20 ;

[0035] Step 3, preparation of earthworm syrup nano-silver hydrogel patch: select sodium polyacrylate as cross-...

Embodiment 1

[0042] (1) Preparation of earthworm syrup: soak earthworm in clean water to wash the soil, take it out and put it on absorbent paper to absorb the water, weigh 10g and put it into a 50mL clean beaker, add 5g of sugar, let stand, earthworm is ready Gradually precipitate body fluid and shrink. After 2 hours, the mixture was centrifuged and filtered 2-3 times, and the leachate was obtained as earthworm syrup.

[0043] (2) Preparation of nano-silver: take nano-silver and place it in distilled water, and ultrasonically treat it for 10 minutes to obtain nano-silver sol; wherein, the mass-volume ratio (g / L) of nano-silver to distilled water is 4:20;

[0044] (3) Preparation of hydrogel patch: select sodium polyacrylate as cross-linking skeleton, aluminum glycolate as cross-linking agent, glycerin as humectant, EDTA and tartaric acid as cross-linking regulator, carbomer, CMC-Na, PVPk30 Propylene Glycol is a penetration enhancer. Weigh 9.6g glycerin and 2g ethylene glycol in a clean ...

Embodiment 2

[0046] Step 1. Prepare earthworm syrup: soak earthworm in clean water to wash the soil, take it out and put it on absorbent paper to absorb the water, and obtain pretreated earthworm, mix the pretreated earthworm with sugar, and , the mass ratio of the pretreated earthworm to white sugar is 1:0.6, and after standing for 2.5 hours, the earthworm gradually precipitates body fluid and shrinks; the mixture is centrifuged and filtered for 2-3 times, and the extract is taken as earthworm syrup;

[0047] Step 2, preparing nano-silver: take nano-silver and place it in distilled water, and ultrasonically treat it for 15 minutes to obtain nano-silver sol; wherein, the mass-volume ratio (g / L) of nano-silver to distilled water is 1:20;

[0048] Step 3, preparation of earthworm syrup nano-silver hydrogel patch: select sodium polyacrylate as cross-linking skeleton, aluminum glycolate as cross-linking agent, glycerin as humectant, EDTA and tartaric acid as cross-linking regulator, carbomer, ...

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Abstract

The invention discloses a earthworm syrup nano-silver hydrogel patch and a preparation method thereof. The preparation method comprises preparing the earthworm syrup; preparing nano-silver sol; and preparing the earthworm syrup nano-silver hydrogel patch. The patch of the present invention is to add antibacterial material nano-silver into the earthworm syrup, "strong combination", so that it is efficient, safe and not easy to produce drug resistance; a new dosage form of hydrogel patch is made, which is not only convenient and comfortable, but also non-toxic Contamination of clothes has a high utilization rate of drugs, and at the same time, its moisturizing characteristics play a role in continuous cooling, which helps wound healing and improves the efficacy and quality of the product.

Description

technical field [0001] The invention belongs to the technical field of drug research and development, and in particular relates to a nano-silver hydrogel patch for earthworm syrup and a preparation method thereof. Background technique [0002] Burns and scalds are accidental injuries that we often encounter in our daily life. The causes of burns and scalds are different, but the first principles of treating burns and scalds are all the same. Generally, it is necessary to clear away heat and solve problems such as wound infection, pain and healing. At present, there are many kinds of medicines for burns and scalds, mainly including traditional Chinese medicines and western medicines. Traditional Chinese medicines take effect slowly and are relatively complicated to prepare. Western medicines are quick in efficacy but prone to drug resistance. The dosage forms are mostly ointments, oils, etc., which are very easy to contaminate clothes , Inconvenient to use. [0003] Dilong i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/62A61K9/70A61P31/04A61P29/00A61P17/02A61K33/38
CPCA61K9/7023A61K33/38A61K35/62A61K47/38A61P17/02A61P29/00A61P31/04A61K2300/00
Inventor 李丽霞卢先云李芳龙冯鑫陈容殷中琼邹元锋宋旭梁晓霞
Owner SICHUAN AGRI UNIV
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