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Silk fibroin material and preparation method thereof

A silk fibroin and nanomaterial technology, which is applied in the field of silk fibroin material and its preparation, can solve problems such as not being well improved, and achieve the effects of good application prospect, good air permeability and simple preparation method.

Inactive Publication Date: 2018-12-28
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned shortcomings are still not well improved, and people are in urgent need of a wound repair dressing with good antibacterial performance, good comfort, low cost and easy preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve nano-titanium dioxide with a particle size of 10nm in an aqueous solution, add sodium dodecylbenzenesulfonate, the molar ratio of sodium dodecylbenzenesulfonate to nano-titanium dioxide is 2:1, react under stirring conditions for 2 hours, take out , obtain surface-modified nanomaterials after drying; (2) disperse surface-modified nanomaterials and silk fibroin in water, add particle diameter as nano-silver, chitosan and aloe vera of 10nm, mix and stir for 1 hour , to obtain an electrospinning stock solution, the molar ratio of silk fibroin to surface-modified nanomaterials is 3:1; and (3) injecting the electrospinning stock solution into a spinning device, and spinning to obtain a silk fibroin material. The mass fraction of nano-silver in the silk fibroin material is 1%, the mass fraction of chitosan is 2%, and the mass fraction of aloe is 0.5%.

Embodiment 2

[0022] Dissolve nano-titanium dioxide with a particle size of 50nm in an aqueous solution, add polyvinyl alcohol, the molar ratio of polyvinyl alcohol to nano-titanium dioxide is 3:1, react under stirring conditions for 3 hours, take out and dry to obtain surface-modified nano-titanium dioxide Material; (2) disperse the surface-modified nanomaterial and silk fibroin in formic acid, add nano-silver, chitosan and aloe with a particle size of 30nm, mix and stir for 1.5 hours to obtain the electrospinning stock solution , the molar ratio of silk fibroin to surface-modified nanomaterials is 5:1; and (3) injecting the electrospinning stock solution into a spinning device, and spinning to obtain the silk fibroin material. The mass fraction of nano-silver in the silk fibroin material is 2%, the mass fraction of chitosan is 1%, and the mass fraction of aloe is 0.5%.

Embodiment 3

[0024] Dissolve nano-titanium dioxide with a particle size of 100nm in an aqueous solution, add sodium dodecylbenzenesulfonate, the molar ratio of sodium dodecylbenzenesulfonate to nano-titanium dioxide is 4:1, and react for 5 hours under stirring conditions, Take out and dry to obtain surface-modified nanomaterials; (2) disperse the surface-modified nanomaterials and silk fibroin in water, add nano-silver, chitosan and aloe whose particle diameter is 50nm, and mix uniformly Stir for 2 hours to obtain an electrospinning stock solution, the molar ratio of silk fibroin to surface-modified nanomaterials is 8:1; and (3) inject the electrospinning stock solution into a spinning device, and spin to obtain the Silk fibroin material. The mass fractions of nano-silver and chitosan in the silk fibroin material are both 3%, and the mass fraction of aloe is 1%.

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Abstract

The invention provides a silk fibroin material and a preparation method thereof. The method comprises the following steps of (1) dissolving nano titanium dioxide in an aqueous solution, adding a surfactant, reacting under stirring for 2-5 hours, and taking out and drying to obtain surface-modified nanomaterials; (2) dispersing the surface-modified nanomaterials and silk fibroin in a solvent, adding nano silver, chitosan and aloe vera, mixing uniformly, and stirring for 1-2 hours to obtain an electrospinning stock solution; (3) injecting the electrospinning stock solution into a spinning device, and obtaining the silk fibroin material by spinning. The preparation method is simple and easy to operate. The prepared silk fibroin material has good gas permeability, light and comfortable performance and very good antibacterial properties.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a silk fibroin material and a preparation method thereof. Background technique [0002] Among the current medical materials, wound dressings have received more and more attention. The existing dressings have many shortcomings that limit their application, such as: poor air permeability, heavy weight, poor antibacterial performance, and high cost. Therefore, researchers have begun to pay more attention to the improvement of these aspects, such as adding antibacterial materials and changing the shape. However, the above-mentioned shortcomings are still not well improved, and people are in urgent need of a wound repair dressing with good antibacterial performance, good comfort, low cost and easy preparation. Contents of the invention [0003] In order to solve the above technical problems, the present invention provides a silk fibroin material, which has good antibacterial proper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F4/00D01F1/10
CPCD01F1/103D01F4/00
Inventor 李苏杨徐勤霞成清明
Owner SUZHOU BEC BIOLOGICAL TECH