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Glacier water composite extract utilizing radix gentianae, phyllanthus emblica and meconopsis quintuplinervia regel and preparation method and application of glacier water composite extract

A technology of compound extract and Meconian wormwood is applied in the directions of skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc. problems, to shorten the extraction time, optimize the extraction effect, and reduce the loss of active ingredients

Active Publication Date: 2019-01-04
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no reports about extracting gentian, emblica, and Meconopsis five veins from glacier water, nor are there reports on using the compound extracts of these three plants or the compound extracts of glacier water to prepare external skin preparations

Method used

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  • Glacier water composite extract utilizing radix gentianae, phyllanthus emblica and meconopsis quintuplinervia regel and preparation method and application of glacier water composite extract
  • Glacier water composite extract utilizing radix gentianae, phyllanthus emblica and meconopsis quintuplinervia regel and preparation method and application of glacier water composite extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Gentiana (whole herb), emblica (fruit) and Meconopsis meconopsis (whole herb) with a water content of less than 5% are taken respectively and pulverized to pass through an 80-mesh sieve.

[0033] Take 10 g of pulverized medicinal materials and mix them, add 600 mL of glacier water, immerse and stir at room temperature for extraction at a stirring speed of 400 rpm to obtain an extract. The extraction time was 10, 20, 30, 40, 50 min respectively. Centrifuge and take the supernatant.

[0034] The glacier water is taken from Dorje Qudeng Nima Spring in the Himalayas (5128 meters above sea level). The deuterium content in the glacier water is 134ppm, pH=7.4, does not contain bromate, and contains the following components: Sr 2+ 0.2~0.5mg / L, K+ 0.5~10.0mg / L, Na + 1.0~5.0mg / L, Ca 2+ 14.0~30.0mg / L and Mg 2+ 2.0-10.0 mg / L; and glacier water does not contain insoluble solids or suspended matter, and the total soluble solids content is 80-100 mg / L.

[0035] In addition, an eq...

Embodiment 2

[0040] Example 2 total flavone extraction rate

[0041] With Al(NO 3 ) 3 -NaNO 2 -NaOH method was used to calculate the extraction rate of total flavonoids, and quercetin was used as a standard for detection.

[0042] Preparation of standard curve: Add 50 μL 5% NaNO to 300 μL quercetin standard solution with different concentrations 2 solution, after mixing, place it at room temperature for 6min, then add 50μL of 10% Al(NO 3 ) 3 After mixing, place it at room temperature for 6 minutes, then add 400 μL of 4% NaOH solution and 100 μL of distilled water, mix it and leave it at room temperature for 15 minutes, make 3 copies of quercetin standard solution with the same concentration in parallel, measure the OD value at 500 nm, and use each concentration Average OD of quercetin standard solution 500 values ​​as a standard curve.

[0043] Preparation and detection of sample solution to be tested: take 300 μL sample solution, add 50 μL 5% NaNO 2 solution, after mixing, place i...

Embodiment 3

[0049] Example 3 total polyphenol leaching rate

[0050] The leaching rate of total polyphenols was calculated by the Folin-Ciocalteu method, and gallic acid was used as a standard for detection.

[0051] Preparation of standard curve: Add 0.5 mL of 10% Folin-Ciocalteu reagent to 0.1 mL of gallic acid standard solution of different concentrations, mix, and add 0.4 mL of 7.5% Na 2 CO 3 Solution, after mixing, place it at room temperature for 60min, make 3 parallel gallic acid standard solutions of the same concentration, measure the OD value at 765nm, take the average OD of the gallic acid standard solution of each concentration 765 values ​​as a standard curve.

[0052] Preparation and detection of the sample solution to be tested: Take 0.1 mL of the sample solution obtained in Example 1, add 0.5 mL of 10% Folin-Ciocalteu reagent, mix, and add 0.4 mL of 7.5% Na 2 CO 3 Solution, after mixing, place it at room temperature for 60min, parallel 3 parts, measure the OD value of ...

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Abstract

The invention belongs to the field of plant extraction and the field of daily chemicals, and particularly relates to glacier water composite extract utilizing radix gentianae, phyllanthus emblica andmeconopsis quintuplinervia regel. A preparation method includes the steps that the radix gentianae, phyllanthus emblica and meconopsis quintuplinervia regel are mixed with glacier water for extraction; the composite extract contains total flavone, total polyphenol and total iridoid glycosides. The glacier water is adopted for extraction, in this way, the extraction effect is improved remarkably, the technology is simple, and the obtained composite extract can effectively clear off free radicals, has the effect of ageing resistance, can be applied to preparation of a skin external preparation,and is particularly applied to preparation of skin external preparations for clearing off free radicals and ageing resistance.

Description

technical field [0001] The present invention relates to the fields of plant extracts and daily chemicals, in particular to glacier water composite extracts of gentian, emblica and meconopsis meconopsis, a preparation method and application. Background technique [0002] There are about 400 species of Gentiana, most of which are distributed in the northern temperate zone. There are 247 species in my country, all over the country, most of which are concentrated in the southwest mountainous areas, mainly growing in alpine driftstone beaches, alpine meadows and shrubs. Known for their blue flowers, gentians are the most prized type of wild flower. According to the "Chinese Pharmacopoeia", there are four kinds of original plants of gentian, namely gentian (G.scabra), gentian (G.manshurica), gentian (G.triflora), gentian (G. rigescens), its dried roots and rhizomes can clear away heat and dampness, and relieve liver and gallbladder fire. Studies have shown that gentian extract ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/08
CPCA61Q19/08A61K8/97A61K2800/805
Inventor 章漳蒋耀权李俊河野善行
Owner JALA GROUP CORPORATION
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