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Preparation method of chiral separation membrane

A technology of chiral separation and chiral molecules, which is applied in the direction of semipermeable membrane separation, chemical instruments and methods, membranes, etc., can solve the problems of cumbersome preparation of chiral separation membranes, and achieve no chemical pollution, strong universality, The effect of simple implementation steps

Inactive Publication Date: 2019-01-04
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a method for preparing chiral separation membranes by adsorption, so as to overcome the cumbersome shortcomings of chiral separation membrane preparation

Method used

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  • Preparation method of chiral separation membrane

Examples

Experimental program
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Effect test

Embodiment 1

[0029] A preparation method of a chiral separation membrane with a compact surface layer and a pore size of 7 nm, the steps are as follows:

[0030] (1) Prepare two self-assembled micellar membranes of the same size formed by polymers containing carboxyl groups, with a concentration of 0.5mg / ml tetrachloroauric acid homogeneous solution;

[0031] (2) Put two ultrafiltration membranes of the same size into the above tetrachloroauric acid solution, shake at room temperature, and absorb for 6h;

[0032] (3) Then the adsorbed film is cleaned with deionized water;

[0033] (4) Prepare a sodium borohydride solution with a concentration of 0.1 mg / ml, put the cleaned membrane into the solution, shake at room temperature, and perform a reduction reaction for 8 hours;

[0034] (5) Take out the membrane, wash it with deionized water, and put the two membranes into two petri dishes respectively;

[0035] (6) The L-cysteine ​​solution and the D-cysteine ​​solution with a concentration of...

Embodiment 2

[0039] A preparation method of a chiral separation membrane with a micelle structure and a pore diameter of 11 nm, the steps are as follows:

[0040] (1) Prepare two self-assembled micellar membranes of the same size formed by a polymer containing pyridine, and prepare a homogeneous solution of 0.5mg / ml tetrachloroauric acid with a concentration;

[0041] (2) Put the above-mentioned two micellar films of equal size into the above-mentioned tetrachloroauric acid solution, shake at room temperature, and absorb for 6h;

[0042] (3) Then the adsorbed film is cleaned with deionized water;

[0043] (4) Prepare a sodium citrate solution with a concentration of 0.1 mg / ml, put the cleaned membrane into the solution, shake at room temperature, and perform a reduction reaction for 8 hours;

[0044] (5) Take out the membrane, wash it with deionized water, and put the two membranes into two petri dishes respectively;

[0045] (6) The L-cysteine ​​solution and the D-cysteine ​​solution wi...

Embodiment 3

[0052] A preparation method of a chiral separation membrane with a micelle structure and a pore size of 6.8nm, the steps are as follows:

[0053] (1) Prepare two identically sized blended membranes containing sulfonic acid groups, with a concentration of 1mg / ml tetrachloroauric acid homogeneous solution;

[0054] (2) Put the above-mentioned two micellar membranes of equal size into the above-mentioned tetrachloroauric acid solution, shake at room temperature, and absorb for 24h;

[0055] (3) Then the adsorbed film is cleaned with deionized water;

[0056] (4) Prepare an ethylenediamine solution with a concentration of 0.1 mg / ml, put the cleaned membrane into the solution, shake at room temperature, and perform a reduction reaction for 8 hours;

[0057] (5) Take out the membrane, wash it with deionized water, and put the two membranes into two petri dishes respectively;

[0058] (6) L-dopamine and D-dopamine solutions with a concentration of 5 mg / ml were prepared, and the pre...

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Abstract

The invention discloses a preparation method of a chiral separation membrane. The preparation method of the chiral separation membrane comprises the following steps: soaking a polymer membrane in an aqueous solution containing metal ions; taking out the polymer membrane a period of time later; transferring the polymer membrane into the aqueous solution containing a reducing agent; vibrating to enable the metal ions which are adsorbed to the surface of the membrane to be converted into metal elements; soaking the membrane loaded with metal in a chiral molecular solution which contains thiol anddiphenol structures; taking out the membrane a period of time later; and washing chiral molecules which are not adsorbed with deionized water to form the chiral separation membrane. The preparation method of the chiral separation membrane is simple and efficient, conditions are gentle, and large-scale application can be realized.

Description

technical field [0001] The invention belongs to the field of novel separation materials, and in particular relates to a preparation method of a chiral separation membrane. Background technique [0002] Chirality is an important characteristic of compounds and is highly relevant to many important biological processes. Chirality has a profound impact in the fields of medicine, biology, food additives and materials. Due to the limited quantity of natural chiral substances and the difficulties of high cost and low yield in synthetic technology, chiral resolution has become a hot research topic. The early chiral resolution methods were gas and liquid chromatography resolution methods, but the derivatization process was cumbersome and time-consuming, and might cause racemization of analytes, which would affect the analysis results. Later, people also studied the use of crystallization, chemical and enzymatic methods for chiral resolution, but they could not be effectively used b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00
CPCB01D67/0079B01D2323/46B01D2325/00
Inventor 易砖李璇孙志娟
Owner ZHEJIANG UNIV OF TECH
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