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Preparation method of oriented fiber reinforced artificial blood vessel

An artificial blood vessel, fiber-reinforced technology, applied in medical science, prosthesis, etc., can solve problems such as insufficient orientation of artificial blood vessels

Active Publication Date: 2019-01-11
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem of insufficient orientation degree of existing artificial blood vessels, the present invention provides a preparation method of oriented fiber reinforced artificial blood vessels. The specific technical scheme of the present invention is:

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] A method for preparing an oriented fiber reinforced artificial blood vessel, the preparation steps are as follows:

[0028] a. Preparation of Polyurethane Solution

[0029] Mix polyurethane and N,N-dimethylformamide at a mass ratio of 1:9 to 2:8, stir at 20 to 60°C for 2 to 6 hours at a speed of 200 to 800 r / min, and dissolve After completion, a uniform and transparent polyurethane solution is obtained, and the stirred polyurethane solution is put into an environment with a vacuum degree of -0.1 to -0.05 MPa for defoaming for 2 to 6 hours to obtain a uniform polyurethane solution.

[0030] b. Preparation of oriented fiber layer

[0031] The fiber material is opened, carded and impurity removed through the carding machine, so that all crimped fibers become straight and oriented fiber layers with the same straight direction.

[0032] Among them, the unit mass of the oriented fiber layer is 10-20g / m 2 .

[0033] The fiber is one of cotton or wool or silk or polyester f...

Embodiment 1

[0038] a. Preparation of Polyurethane Solution

[0039] Put 10g of polyurethane in 90g of N,N-dimethylformamide, stir at 20-60°C for 2-6 hours at a speed of 200-800r / min, and obtain a uniform and transparent polyurethane solution after complete dissolution. The polyurethane solution after stirring is put into an environment with a vacuum degree of -0.1 to -0.05 MPa for defoaming for 2 to 6 hours to obtain a uniform polyurethane solution.

[0040] b. Preparation of oriented fiber layer

[0041] The cotton fiber material is opened, carded and impurity removed through a carding machine, so that all crimped fibers become an oriented fiber layer that is straightened and in the same straightening direction, and the unit mass of the oriented fiber layer is 10g / m 2 .

[0042] c. Preparation of artificial blood vessels

[0043] Place a metal cylinder mold with a diameter of 4mm and a length of 35cm on the winding machine, and the spindle speed of the winding machine is 50r / min; use ...

Embodiment 2

[0045] a. Preparation of Polyurethane Solution

[0046] Put 20g of polyurethane in 80g of N,N-dimethylformamide, stir at 20-60°C for 2-6 hours at a speed of 200-800r / min, and obtain a uniform and transparent polyurethane solution after complete dissolution. The polyurethane solution after stirring is put into an environment with a vacuum degree of -0.1 to -0.05 MPa for defoaming for 2 to 6 hours to obtain a uniform polyurethane solution.

[0047] b. Preparation of oriented fiber layer

[0048] The wool fiber material is opened, carded and impurity removed through a carding machine, so that all crimped fibers become straight and oriented fiber layers with the same straightening direction, and the unit mass of the oriented fiber layer is 15g / m 2 .

[0049] c. Preparation of artificial blood vessels

[0050] Place a metal cylinder mold with a diameter of 6mm and a length of 50cm on the winding machine, and the spindle speed of the winding machine is 50r / min; use a brush to dip...

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Abstract

The invention relates to a preparation method of oriented fiber reinforced artificial blood vessel, belonging to the technical field of tissue engineering, including the steps: at first, a lay of polyurethane solution is painted on the surface of the blood vessel mold, then the fiber material is arranged on the surface of the polyurethane solution according to a certain direction to form an aligned fib layer, and then a nano film is formed on the surface of the aligned fiber layer through electrostatic spinning, so that the artificial blood vessel with good alignment degree is prepared. The biocompatibility of the prosthesis made by this method is good. The orientation arrangement of the fibers in the prosthesis is conducive to the orderly growth and arrangement of the cells in the prosthesis. The preparation process is relatively safe and the preparation efficiency is high.

Description

technical field [0001] The invention relates to a preparation method of an artificial blood vessel reinforced with oriented fibers, and belongs to the technical field of tissue engineering. Background technique [0002] With the improvement of human living conditions, the incidence of vascular diseases is also increasing. One of the effective means of treating vascular diseases is vascular transplantation. However, because the number of allogeneic blood vessels used for transplantation is scarce and cannot meet medical needs, artificial blood vessels have become the most suitable substitutes. At present, textile artificial blood vessels have been widely used clinically to replace damaged blood vessels in the human body, and have achieved good medical effects. [0003] Many studies have shown that the cells in natural blood vessels are arranged in a certain orientation, and their specific arrangement provides many functions for the function of blood vessels. For example, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/36A61L27/50
CPCA61L27/18A61L27/3604A61L27/3637A61L27/50A61L27/507C08L75/04
Inventor 杨红军翁雅雪李美辰王晗汪林锋张骞庄燕徐卫林
Owner WUHAN TEXTILE UNIV