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Intravascular metal fully degraded high throughput simulation monitoring system based on micro-fluidic chip

A microfluidic chip and monitoring system technology, applied in the direction of applying stable shear force to test the strength of materials, measuring devices, testing wear resistance, etc., can solve the problems of low throughput and long test cycle of evaluation methods, etc. Achieve the effect of speeding up the experiment progress, shortening the research cycle, and solving the long experiment cycle

Inactive Publication Date: 2019-01-11
SOUTHWEST JIAOTONG UNIV
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  • Abstract
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Problems solved by technology

[0004] Aiming at the inability of the existing technology to achieve high-throughput simulation research on the influence of intravascular fluid on the degradation of fully degraded metals, but in the experiment, there is an urgent need for fast and efficient evaluation methods to shorten the research cycle and speed up the progress of the experiment. The present invention provides a A microfluidic chip-based device capable of high-throughput simulation of the effect of intravascular fluid shear stress on the degradation behavior of fully degraded metals. The shear force distribution of the fluid in the blood vessel is obtained, and appropriate parameters are obtained for in vitro simulation, so as to realize the high-throughput simulation of the effect of the shear stress of the fluid in the blood vessel on the degradation behavior of the fully degraded metal, thereby solving the problem of the long test cycle and the common problems of the existing evaluation methods. low volume technical issues

Method used

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  • Intravascular metal fully degraded high throughput simulation monitoring system based on micro-fluidic chip
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  • Intravascular metal fully degraded high throughput simulation monitoring system based on micro-fluidic chip

Examples

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Embodiment 1

[0028] Embodiment 1 (8-channel microfluidic chip):

[0029] The multi-channel microfluidic chip set 2 is a polydimethylsiloxane (PDMS) microfluidic chip, which is formed by bonding a polydimethylsiloxane (PDMS) layer with a microchannel structure and a glass sheet, The PDMS layer height was 4 mm. The surface of the PDMS layer is processed with a microchannel structure, the width of the fluid distribution channel 23 is 400 microns, the width a of the full degradation metal degradation reaction channel 22 is 240 microns, and the height b of the two channels is uniformly 240 microns, so S1=a* b = 57600 microns 2 . The diameter D of the full-degradation metal wire matched with the full-degradation reaction channel of the chip of this embodiment is 160 microns, so S2=π*(D / 2)2=6400π microns 2 , P=S1 / S2=9 / π. Corresponding to the flow rate of the inlet port 21 of the microfluidic chip is 0.72mL / min, it is calculated that the flow rate of the degradation reaction channel is about 0...

Embodiment 2

[0033] Embodiment 2 (4-channel microfluidic chip):

[0034] In this embodiment, only the microfluidic chip in embodiment 1 is replaced with a 4-channel microfluidic chip, and the rest of the content is the same as in embodiment 1. The significance of this example is to illustrate that the number of channels of the microfluidic chip can be determined according to the number of actual experimental samples, and is not limited to that described in Example 1, so as to improve the experimental efficiency. The channels of the microfluidic chip appear in the field of view of the microscope.

[0035] When applying the present invention to simulate the fluid shear stress in the blood vessel to study the action behavior of the fully degraded metal degradation behavior, the following steps can be carried out:

[0036] Prepare a microfluidic chip and a fully degradable metal wire with matching sizes, implant the fully degradable metal wire into the degradation reaction channel of the micr...

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Abstract

The invention discloses an intravascular metal fully degraded high throughput simulation monitoring system based on a micro-fluidic chip. The system is primarily composed of a pump unit (4) which provides fluid power, a multichannel micro-fluidic chip unit (3) and a fluid collecting device (6) connected to the liquid outlet of the multichannel micro-fluidic chip unit. The shear force distributionof a metal wire model to the fluid in channels is simulated by adopting the micro-fluidic chip and a channel dimensional design of the characteristic micro-fluidic chip and an optimized channel fluidflow rate to ensure that the size of the fluid shear force of the fully degraded metal wire in the reaction channel reaches the effect of simulating the fluid shear force in the blood vessel in vivo,so that the technical problem that an existing evaluation means is long in experimental period and low in throughput is solved effectively.

Description

technical field [0001] The present invention relates to the application of microfluidic chip technology to the research field of biomedical engineering and metal corrosion science, in particular to a microfluidic chip-based high-throughput simulation of intravascular fluid shear stress on the degradation behavior of fully degraded metals functioning device. Background technique [0002] The application of biodegradable metals in the field of biomedical materials has broken through the traditional mode of focusing on the development of corrosion-resistant metals for biomedical metals. Implants made of these biodegradable metal materials need to temporarily provide mechanical support during the healing process of injured or pathological tissue. When the tissue gradually restores its function, the material should be gradually degraded and metabolized, that is, completely replaced by the tissue. In recent years, the use of fully degradable metals as materials for orthopedic rep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N17/00G01N3/24G01N3/56
CPCG01N3/24G01N3/567G01N17/006G01N2203/0048
Inventor 王进尚腾达赵安莎李欣游思铭黄楠
Owner SOUTHWEST JIAOTONG UNIV
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