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New application of hydroxytyrosol and derivatives thereof in preparation of antidepressant products

A technology of hydroxytyrosol and derivatives, which is applied in the field of biomedicine, can solve the problems of hydroxytyrosol depression that has not been disclosed, and achieve the effect of preventing recurrence and reducing side effects

Active Publication Date: 2019-01-18
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art has disclosed the preparation method of hydroxytyrosol and its use in the manufacture of products for protecting cartilage, preventing and treating osteoarthritis, lowering blood fat, and treating macular eye disease. However, the use of hydroxytyrosol as the prevention and treatment of depression Not seen yet

Method used

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  • New application of hydroxytyrosol and derivatives thereof in preparation of antidepressant products
  • New application of hydroxytyrosol and derivatives thereof in preparation of antidepressant products
  • New application of hydroxytyrosol and derivatives thereof in preparation of antidepressant products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of Hydroxytyrosol Sublingual Tablets

[0029] Sublingual lozenges are prepared by conventional procedures, and the formula (made into 1000 tablets) is as follows:

[0030]

[0031] Using wet granulation and tabletting method, weigh the prescribed amount of sucrose and microcrystalline cellulose and mix evenly, then mix evenly with hydroxytyrosol and 10% starch slurry, add it to the soft material as a binder, pass through a 20-mesh sieve, and wet the granules Dry at 70°C for 1 h, sieve through a 20-mesh sieve, add talcum powder, mix evenly, and press into tablets.

Embodiment 2

[0032] The preparation of embodiment 2 hydroxytyrosol soft capsules

[0033] The soft capsules are prepared through conventional procedures, and the formula (making 1000 capsules) is as follows:

[0034]

[0035] Take the prescribed amount of hydroxytyrosol, add vegetable oil to dissolve, and use it as a liquid medicine; heat glycerin and water to 70 °C, stir to dissolve, add gelatin, stir for 2 hours, remove the floating foam, and filter. Turn on the soft capsule machine, turn on the left and right plastic boxes and the spray body for heating, and at the same time turn on the water pump circulation and refrigeration. The spray body is set at 43 °C, and the left and right plastic boxes are set at 60 °C. After the preheating is completed, adjust the thickness of the leather on both sides to be 0.70 mm. After the rubber has been debugged, the liquid medicine is added into the hopper, the loading is adjusted, and the soft capsule is pressed. Wash the soft capsules and let t...

Embodiment 3

[0036] The preparation of embodiment 3 hydroxytyrosol tablet

[0037] Tablets are prepared by conventional procedures, and the formula (making 1000 tablets) is as follows:

[0038]

[0039]Mix powdered sugar, microcrystalline cellulose and sodium carboxymethyl starch, then mix hydroxytyrosol and starch slurry and add it as a binder to make a soft material, pass through a 14-mesh nylon sieve to make wet granules, and dry at 45 °C. Add talcum powder, mix well, pass through a 12-mesh nylon sieve, pass the content test of the granules, and press into tablets to obtain.

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PUM

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Abstract

The invention provides the application of hydroxytyrosol and derivatives thereof in preparation of antidepressant products, and belongs to the field of biomedicine. Hydroxytyrosol derivative are at least one selected from that group consist of hydroxytyrosol salts, hydroxytyrosol esters and hydroxytyrosol ether, and can be derived from chemical synthesis, microbial fermentation or animal and plantextraction. The products for preventing and treating depression may be medicines, foods, functional foods, and the like. The antidepressant prepared with hydroxytyrosol and its derivatives as activeingredients has the effects of preventing and treating depression and preventing the recurrence of depression, and can be used for reducing the incidence of depression and improving the quality of life of patients with depression.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a new application of hydroxytyrosol. Background technique [0002] With the continuous development of the social economy, the acceleration of the pace of life, the increasingly fierce social competition, people's psychological pressure is gradually increasing, and the incidence of depression is increasing year by year. According to the World Health Organization, the prevalence of depression in the world is estimated to be about 3%-5%, totaling about 100-200 million people. By 2022, depression will be the largest disease burden in developing countries. [0003] Depression, also known as depressive disorder, is a group of clinical symptoms or states centered on the self-experience of depressed mood, with persistent and significant spontaneous low mood as the main clinical feature, and is the main type of mood disorder. The clinical symptoms mainly include: depression, alien...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/222A61K45/06A61P25/24A61P25/20
CPCA61K45/06A61P25/20A61P25/24A61K31/05A61K31/222
Inventor 凌沛学吴季栩邵华荣郭新艳边玲刘飞程艳玲张建强张岱州李帅广
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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