Chiral 1-phosphanorbornadiene derivative and its synthesis method

Abstract

The invention belongs to the field of organic chemical synthesis, and particularly relates to a 1-phospha norborneol diene derivative with application values in the asymmetric catalysis field and a synthesis method thereof. A series of phosphorus chiral center chiral phosphorous ligands are synthesized; a 1-phospha norborneol diene framework and a chiral sulphoxide type compound are combined; wideapplication prospects are realized in the asymmetrical synthesis field. The derivative has the following structure general formula shown in description.

Description

technical field [0001] The invention belongs to the field of organic chemical synthesis, in particular to 1-phosphanorbornadiene compounds used in the field of asymmetric catalysis and a synthesis method thereof. Background technique [0002] In the field of asymmetric catalysis, chiral organophosphides are important ligands or catalysts. Due to the lone pair of electrons, trivalent organophosphides can be used as ligands to complex with metals to form metal complexes, participate in asymmetric reactions catalyzed by metals, and act as catalysts to attack electron-deficient alkenes to generate carbanions. , and catalyze chemical reactions. In previous studies, chemists focused on the selection of the chiral backbone linked to phosphorus, that is, the chirality of the target product is generated through the induction of the chiral backbone. Because of the nature of phosphorus itself, the phosphorus chiral center is difficult to synthesize and easy to racemize at high temper...

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Problems solved by technology

[0003] So far, the design of chiral phosphorus-oxygen ligands with phosphorus chiral centers by embedding phosphorus atoms into rigid frameworks remains unreported.

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