Drug delivery and controlled release system with tumor initiation targeting capability and preparation method thereof

A targeted and capable technology, applied in the field of drug delivery controlled release system with tumor-initiating and targeting capabilities, can solve the difficulties of clinical trials, inaccurate evaluation of carrier systems, and the inability of drug delivery systems to precisely target tumor cells etc. to achieve excellent biocompatibility, promote cell uptake, and high pore volume

Active Publication Date: 2019-01-25
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] (2) The research on the nanodiamond / hollow mesoporous silicon drug carrier system belongs to bioengineering. This research is subject to objective conditions, and clinical trials are difficult to carry out in a short period of time. These results cannot fully and truly reflect the situation of human trials, so give Evaluating carrier systems introduces a lot of inaccuracies
[0010] (3) Due to the complexity of the human body, the drug delivery system cannot accurately target tumor cells

Method used

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  • Drug delivery and controlled release system with tumor initiation targeting capability and preparation method thereof
  • Drug delivery and controlled release system with tumor initiation targeting capability and preparation method thereof
  • Drug delivery and controlled release system with tumor initiation targeting capability and preparation method thereof

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Embodiment 1

[0062] 1. Preparation of mercapto-functionalized hollow mesoporous silicon HMSN-SH

[0063] Add 10ml of ammonia water (25%) and 10ml of tetraethyl orthosilicate (TEOS) to the mixed solution containing 60ml of deionized water and 428ml of ethanol in turn, stir at 30°C for 2h, wash and centrifuge twice with ethanol and deionized water , lyophilized to obtain SiO 2 .

[0064] 200mg SiO2 was fully dispersed in 40ml deionized water, and then the suspension was added to a mixture containing 300mg CTAB (60ml deionized water, 60ml ethanol, and 1.1ml ammonia water). The mixture was stirred at 35°C, and after 0.5h, 0.3ml TEOS Add quickly, react for 6 hours and collect by centrifugation, and the product is dispersed in 40ml deionized water to obtain SSiO 2 CTAB / SiO2 2 suspension;

[0065] Under vigorous stirring, 848 mg Na2CO3 was added to the SSiO 2 CTAB / SiO2 2 The suspension was stirred at 50°C for 12 hours, washed with ethanol and water, centrifuged and freeze-dried.

[0066] S...

Embodiment 2

[0087] 1. Preparation of mercapto-functionalized hollow mesoporous silicon HMSN-SH

[0088] Add 10ml of ammonia water (28%) and 10ml of tetraethyl orthosilicate (TEOS) to the mixed solution containing 60ml of deionized water and 450ml of ethanol in turn, stir at 30°C for 2h, wash and centrifuge twice with ethanol and deionized water , lyophilized to obtain SiO 2 .

[0089] 200mg SiO2 was fully dispersed in 40ml deionized water, and then the suspension was added to a mixture containing 300mg CTAB (60ml deionized water, 60ml ethanol, and 1.1ml ammonia water). The mixture was stirred at 35°C, and after 0.5h, 0.3ml TEOS Add quickly, after reacting for 6h and collect by centrifugation, the product is dispersed in 40ml deionized water to obtain SSiO 2 CTAB / SiO2 2 suspension;

[0090] Under vigorous stirring, 848 mg Na2CO3 was added to the SSiO 2 CTAB / SiO2 2 in the suspension, stirred at 50°C for 12 hours, washed with ethanol and water, centrifuged and freeze-dried;

[0091] S...

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Abstract

The invention relates to a drug delivery and controlled release system with tumor initiation targeting capability and a specific preparation method thereof, the controlled release system has a three-layer core-shell structure, wherein the inner layer is mesoporous silicon nanoparticles loaded with drugs, the pores of the mesoporous silicon nanoparticles loaded with drugs are sealed with activatednanodiamond, the middle layer is a polylysine layer, and the outer layer is a maleic anhydride polylysine layer. The preparation process comprises the following steps: preparing sulfhydryl-functionalized hollow mesoporous silicon HMSN-SH, S-(2-aminoethylmercapto) 2-acrylpyridine hydrochloride, functionalization of disulfide, drug-loaded nanoparticles, preparation of adamantane-terminated polylysine, preparation of maleic anhydride-terminated polylysine, self-decoration of polylysine layer by layer, self-decoration of maleic anhydride-terminated polylysine layer by layer; the drug delivery system has good passive targeting ability and stealth property. The drug system is enriched and released in cancer tissues. The drug utilization rate is high, and the toxicity and side effects are small.

Description

technical field [0001] The invention relates to the field of drug controlled release, in particular to the field of a drug delivery controlled release system with tumor-initiating targeting capability and a specific preparation method thereof. Background technique [0002] In recent years, malignant tumors have become an increasing threat to people's health, and the morbidity and mortality have increased year by year. Although there are many methods and methods for treating tumors, chemotherapy is still the main method for treating tumors. Therefore, constructing a tumor-targeting drug carrier system is the only choice to solve the problem of chemotherapy. At present, among the anticancer drug carrier systems, the organic / polymer carriers represented by liposomes and micelles are the most common. However, the shortcomings of organic / polymer carriers such as low drug loading, poor stability, unsuitable size, and easy aggregation limit their further development among the cur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/34A61K31/704A61P35/00
CPCA61K9/5115A61K9/5146A61K31/704A61P35/00
Inventor 李草陈重银卢金博罗毕矗陈辉万立辉
Owner HUBEI UNIV
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