Application of 3'-deoxyhypoxanthine nucleoside in preparation of medicines, foods or health products for various diseases

A technology of deoxyinosine and health products, which is applied in the application field of products, and can solve the problems of insufficient therapeutic effect of drugs for treating hyperlipidemia

Pending Publication Date: 2019-01-25
SHENZHEN SUNNY BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of insufficient therapeutic effect of drugs for treating hyperlipidemia in the prior art, the present invent

Method used

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  • Application of 3'-deoxyhypoxanthine nucleoside in preparation of medicines, foods or health products for various diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Synthesis of 3'-deoxyinosine:

[0075] Weigh 20.0g of 3'-deoxyadenosine, add 500mL of pure water to dissolve, then add 20.0mg of adenosine deaminase, heat in a water bath at 37°C for 1 hour, and concentrate under reduced pressure and vacuum at 0.07MPa and 40°C to a small amount. Crystals were precipitated, then heated at 37°C to dissolve, and then stood at 4°C for 12 hours to obtain recrystallization and 3'-deoxyinosine (HPLC≥98%)

Embodiment 2

[0077] This test verifies the effect of 3'-deoxyinosine in preventing or treating hyperlipidemia.

[0078] 1. Model preparation

[0079] 20 SD rats, male, clean grade, weighing 180-200 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army, and the experimental animal use license number is SCXK2015-0001. Rat diet standard feed (LAD0020, Nantong Trofe), rat 60% high-fat diet (mixed hyperlipidemia model feed, Nantong Trofe).

[0080] After the rats were fed adaptively for one week, they were weighed, and 20 experimental animals were randomly divided into 2 groups, 10 in each group. The blank control group was given diet, and the model group was given high-fat feed. After continuous feeding for 4 weeks, fasting After 12 hours, the rats were weighed 1 hour after the last administration, and blood was collected by docking the tail.

[0081] The blood was placed at room temperature for 2 hours, cent...

Embodiment 3

[0090] This experiment verified the effect of 3'-deoxyinosine in preventing or treating food-induced obesity.

[0091] 1. Test animals and feed

[0092] Thirty SD rats, male, clean grade, weighing 180-200 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army, and the license number for the use of experimental animals is SCXK2015-0001. Rat diet standard feed (LAD0020, Nantong Trofe), rat 60% high-fat diet (Research diets D12492, 60% cal, USA, Research Diets).

[0093] 2. Modeling of rats with food-induced obesity

[0094] After the rats were fed adaptively for one week, they were weighed, and 20 experimental animals were randomly divided into 2 groups, 10 in each group. The blank control group was given diet, and the model group was given high-fat feed. After continuous feeding for 4 weeks, fasting 12 hours later, weighed 1 hour after the last administration, docked the tail to take blood, pla...

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Abstract

The present invention relates to the field of pharmaceuticals and provides the application of 3'-deoxyhypoxanthine nucleosides in the preparation of foods, medicines or health products for the prevention or treatment of food-borne obesity or hyperlipidemia provides, provides the application of 3'-deoxyhypoxanthine nucleosides in the preparation of foods, medicines or health products for the prevention of hypertension or arteriosclerosis, and also provides the application of 3'-deoxyhypoxanthine nucleoside in preparation of skin care products. A study of that present invention show that the 3'-deoxyhypoxanthine nucleosides have significant therapeutic effect on hyperlipidemia, reduces the body weight of foodborne obesity, and overcomes the existing technical bias. And the 3'-deoxyhypoxanthine nucleosides have a more comprehensive efficacy in the prevention or treatment of hyperlipidemia than the existing drugs. And the 3'-deoxyhypoxanthine nucleoside can effectively prevent the occurrence of hypertension and arteriosclerosis by decreasing the content of lipid and high density lipoprotein in serum.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of 3'-deoxyinosine in the preparation of food, medicine or health products for the prevention or treatment of hyperlipidemia and food-induced obesity. 3'-deoxyinosine The application of nucleosides in the preparation of food, medicine or health products for preventing hypertension or arteriosclerosis, and the application of 3'-deoxyinosine nucleoside in the preparation of skin care products. Background technique [0002] About 12 million people die of cardiovascular and cerebrovascular diseases every year in the world, and hyperlipidemia is one of the main causes of cardiovascular and cerebrovascular diseases. There are as many as 160 million hyperlipidemia patients in China. Hyperlipidemia damages the body insidiously, gradually, progressively and systemically. Its direct damage is to accelerate systemic atherosclerosis, which in turn leads to numerous related...

Claims

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Application Information

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IPC IPC(8): A61K31/708A61P9/00A61P3/06A61P3/04A61P9/12A61P9/10A61P17/18A61P31/02A61P31/04A61P31/10A61P37/04A61Q19/08A61Q17/00A61K8/60C12P19/40A23L33/10
CPCA23V2002/00A61K8/606A61K31/708A61Q17/005A61Q19/08A23L33/10A61P3/04A61P3/06A61P9/00A61P9/10A61P9/12A61P17/18A61P31/02A61P31/04A61P31/10A61P37/04C12P19/40A23V2200/3262A61K8/60A61Q19/00A23L33/13
Inventor 王雪艳唐旭东张景照于录许剑怡王宏娟杨莹
Owner SHENZHEN SUNNY BIO TECH CO LTD
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