Application of 3'-deoxyhypoxanthine nucleoside in preparation of medicines, foods or health products for various diseases
A technology of deoxyinosine and health products, which is applied in the application field of products, and can solve the problems of insufficient therapeutic effect of drugs for treating hyperlipidemia
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Embodiment 1
[0074] Synthesis of 3'-deoxyinosine:
[0075] Weigh 20.0g of 3'-deoxyadenosine, add 500mL of pure water to dissolve, then add 20.0mg of adenosine deaminase, heat in a water bath at 37°C for 1 hour, and concentrate under reduced pressure and vacuum at 0.07MPa and 40°C to a small amount. Crystals were precipitated, then heated at 37°C to dissolve, and then stood at 4°C for 12 hours to obtain recrystallization and 3'-deoxyinosine (HPLC≥98%)
Embodiment 2
[0077] This test verifies the effect of 3'-deoxyinosine in preventing or treating hyperlipidemia.
[0078] 1. Model preparation
[0079] 20 SD rats, male, clean grade, weighing 180-200 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army, and the experimental animal use license number is SCXK2015-0001. Rat diet standard feed (LAD0020, Nantong Trofe), rat 60% high-fat diet (mixed hyperlipidemia model feed, Nantong Trofe).
[0080] After the rats were fed adaptively for one week, they were weighed, and 20 experimental animals were randomly divided into 2 groups, 10 in each group. The blank control group was given diet, and the model group was given high-fat feed. After continuous feeding for 4 weeks, fasting After 12 hours, the rats were weighed 1 hour after the last administration, and blood was collected by docking the tail.
[0081] The blood was placed at room temperature for 2 hours, cent...
Embodiment 3
[0090] This experiment verified the effect of 3'-deoxyinosine in preventing or treating food-induced obesity.
[0091] 1. Test animals and feed
[0092] Thirty SD rats, male, clean grade, weighing 180-200 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army, and the license number for the use of experimental animals is SCXK2015-0001. Rat diet standard feed (LAD0020, Nantong Trofe), rat 60% high-fat diet (Research diets D12492, 60% cal, USA, Research Diets).
[0093] 2. Modeling of rats with food-induced obesity
[0094] After the rats were fed adaptively for one week, they were weighed, and 20 experimental animals were randomly divided into 2 groups, 10 in each group. The blank control group was given diet, and the model group was given high-fat feed. After continuous feeding for 4 weeks, fasting 12 hours later, weighed 1 hour after the last administration, docked the tail to take blood, pla...
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