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Imidazole ionic liquid modified bacterial cellulose antibacterial film and preparation method thereof

A technology of imidazole ionic liquid and bacterial cellulose membrane, which is applied in the field of imidazole ionic liquid modified bacterial cellulose antibacterial membrane and its preparation, can solve the problems of bacterial cellulose not having antibacterial properties, limited application scope and the like, so as to inhibit skin infection , Conducive to wound recovery, the effect of high mechanical strength

Active Publication Date: 2019-01-29
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bacterial cellulose itself does not have antibacterial properties, which limits its application range

Method used

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  • Imidazole ionic liquid modified bacterial cellulose antibacterial film and preparation method thereof
  • Imidazole ionic liquid modified bacterial cellulose antibacterial film and preparation method thereof
  • Imidazole ionic liquid modified bacterial cellulose antibacterial film and preparation method thereof

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preparation example Construction

[0024] The preparation method of imidazolium ionic liquid modified bacterial cellulose antibacterial membrane comprises the steps:

[0025] Step 1: Dissolve carbonyldiimidazole in DMSO to obtain a mixed liquid, place the bacterial cellulose membrane in the mixed liquid, immerse the bacterial cellulose membrane in the mixed liquid, stir the mixture at 40-45°C for 24-36 hours, and remove the supernatant The liquid was filtered off to obtain product 1. Product 1 was washed three times with DMSO. The structural formula of bacterial cellulose is shown in formula (1), and the structural formula of product 1 is shown in formula (2).

[0026]

[0027] Step 2: Disperse the product 1 in DMSO again, immerse the product 1 in DMSO, and stir with a certain amount of 1-3-aminopropylimidazole at 40-50°C for 24-36 hours to obtain the product 2. Product 2 was washed three times with DMSO and then three times with acetone. After the washing is completed, the liquid is filtered off, the pro...

Embodiment 1

[0037] 1.025g carbonyldiimidazole was dissolved in 6mL DMSO, 0.5g bacterial cellulose was placed in the mixed liquid, the mixture was stirred at 40°C for 24h, and the liquid was filtered off to obtain product 1. Product 1 was washed three times with DMSO. The product 1 was dispersed in 20 mL DMSO again, 0.75 mL 1-3-aminopropylimidazole was added and stirred at 40° C. for 24 h to obtain the product 2. Product 2 was washed three times with DMSO and then three times with acetone. After the washing was completed, the liquid was filtered off, and the product 2 was vacuum-dried at 40° C. in a vacuum oven for 12 hours. The product 2 and 20 mL of 1-chlorobutane were condensed and refluxed at a temperature of 80°C, and the reaction was completed for 24 hours to obtain the product 3. The product 3 was placed on a rotary evaporator, and the temperature was set at 45°C for 4 hours of reaction, and then the product 3 was placed in a vacuum drying oven and the temperature was set at 45°C ...

Embodiment 2

[0039] 2.05g carbonyldiimidazole was dissolved in 12mL DMSO, 1g bacterial cellulose was placed in the mixed liquid, the mixture was stirred at 40°C for 24h, and the liquid was filtered off to obtain product 1. Product 1 was washed three times with DMSO. Product 1 was dispersed again in 40mL DMSO, and 1.5mL 1-3-aminopropylimidazole was stirred at 40°C for 24h to obtain product 2. Product 2 was washed three times with DMSO and then three times with acetone. After the washing was completed, the liquid was filtered off, and the product 2 was vacuum-dried at 40° C. in a vacuum oven for 12 hours. The product 2 and 40mL 1-chlorobutane were condensed and refluxed at a temperature of 80°C, and the reaction was completed for 24 hours to obtain the product 3. The product 3 was placed on a rotary evaporator, set the temperature at 45°C and reacted for 4 hours, and then placed the product 3 in a vacuum drying oven at a set temperature of 45°C for 12 hours to obtain the target product.

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Abstract

The invention provides an imidazole ionic liquid modified bacterial cellulose antibacterial film and a preparation method thereof. The preparation method comprises the following steps: step 1, dissolving carbonyl diimidazole into DMSO, immersing a bacterial cellulose film into the obtained mixed solution, carrying out stirring at 40 to 45 DEG C for 24 to 36 h, and carrying out filtering and washing so as to obtain a product 1; step 2, immersing the product 1 into DMSO, adding 1-(3-aminopropyl)imidazole, carrying out stirring at 40 to 50 DEG C for 24 to 36 h, and carrying out washing and dryingso as to obtain a product 2; and step 3, immersing the product 2 into halogenated alkane, carrying out a reflux condensation reaction at 80 to 85 DEG C for 24 to 36 hours, and carrying out washing and drying so as to obtain the imidazole ionic liquid modified bacterial cellulose antibacterial film. The imidazole ionic liquid modified bacterial cellulose antibacterial film provided by the invention has sustainable antibacterial properties.

Description

technical field [0001] The invention belongs to the technical field of composite material preparation, in particular to an imidazole ionic liquid modified bacterial cellulose antibacterial film and a preparation method thereof. Background technique [0002] Bacterial cellulose is a natural polymer material, and its nanoscale three-dimensional network structure makes it have unique physical and chemical properties: high crystallinity, high wet strength, high water holding capacity, good biocompatibility and excellent biodegradability, etc. Bacterial cellulose has received extensive attention in biomedical applications. Bacterial cellulose is considered a natural dressing that provides a moist environment to the wound and absorbs wound exudate. However, bacterial cellulose itself does not have antibacterial properties, which limits its application range. Contents of the invention [0003] For the problems existing in the prior art, the invention provides a kind of imidazol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/06C08J5/18C08L1/08
CPCC08B15/06C08J5/18C08J2301/08
Inventor 钱立伟刘文倩许亮王蕊沈钰杨苗秀张楠张素风
Owner SHAANXI UNIV OF SCI & TECH
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