Preparation method of azithromycin taste-masking microspheres

Abstract

The invention relates to a preparation method of azithromycin taste-masking microspheres. After azithromycin and an auxiliary material are heated and melted, then melt is frozen and atomized, the grain sizes of the obtained microspheres are smaller than the grain sizes of microspheres obtained by common wet granulation or hot melting extrusion and granulation, less prepared microspheres are dissolved in water within a short time, the taste-masking effect is good, moreover, because the grain size is small and the particles are smooth, a patient does not have sandy feeling when orally taking theazithromycin taste-masking microspheres, oral taking is facilitated, the patient easily receives the azithromycin taste-masking microspheres, moreover, the production process is simple, and production is facilitated.

Description

【Technical field】 [0001] The invention relates to an antibiotic drug, in particular to a preparation method of azithromycin taste-masking microspheres. 【Background technique】 [0002] Many medicines have certain peculiar smells, such as bitterness, special smell, numbness and so on. These medicines with unacceptable taste are usually made into solid preparations swallowed as a whole, such as coated tablets and capsules. However, formulations swallowed whole are also unsuitable for children or patients who have difficulty swallowing, and suspensions that can be dissolved in water or dispersed into fine particles must be used, such as soluble tablets, granules, solutions or suspensions. But because the medicine in this dosage form is exposed to the outside, it will inevitably directly contact with the taste buds on the oral cavity when taking it, so the bad smell or taste of the medicine can often be felt when taking it. [0003] In the methods of the prior art, the taste-ma...

AI Technical Summary

Problems solved by technology

However, formulations swallowed whole are also unsuitable for children or patients who have difficulty swallowing, and suspensions that dissolve in water or disperse into fine particles must be used, such as soluble tablets, granules, solutions, or suspensions

However, due to exposure, the medicine in this dosage form will inevitably come into direct contact with the taste buds on the oral cavity when taking it, so the bad smell or taste of the medicine can often be felt when taking it.