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Synchronous extraction process of flavonoid glycoside of cotinus coggygria and application thereof

A technology for sumac and fisetin, which is applied in the field of preparation of simultaneously extracting fisetin and myricetin in sumac, can solve the problems of inability to effectively separate total flavonoids, low extraction rate, inconvenience in industrialized production, etc., and achieve significant antioxidant and antitumor activities , the effect of easy industrial production and good development and application prospects

Inactive Publication Date: 2019-02-22
王刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent "New Use and Preparation of Total Flavonoids from Effective Parts of Cotinus Cotinus" (Application No.: CN200910021046.0) discloses a method for extracting total flavonoids from Cotinus cotinus, but the yield of total flavonoids from Cotinus cotinus is very low and cannot be effectively separated The main active ingredients of total flavonoids are fisetin and myricetin, indicating that most of the flavonoids are lost during the extraction of total flavonoids from Cotinus cotinus
The above prior art does not fully consider the chemical structure of each component in Cotinus cotinus, and adopts an unreasonable extraction method, resulting in a low extraction rate or inconvenience to industrialized production

Method used

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  • Synchronous extraction process of flavonoid glycoside of cotinus coggygria and application thereof
  • Synchronous extraction process of flavonoid glycoside of cotinus coggygria and application thereof
  • Synchronous extraction process of flavonoid glycoside of cotinus coggygria and application thereof

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Experimental program
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Effect test

Embodiment 1

[0042] The separation and purification process 1 of fisetin and myricetin in the sumac sumac in embodiment 1

[0043] 1> Processing of raw materials: take the stems and branches of sumac sumac, cut them into slices, dry them in the sun, crush them into powder, and set them aside;

[0044] 2> Reflux extraction: Take 20g of dry sumac stem powder, use about 70% ethanol equivalent to about 20 times the amount of dry sumac dry powder, adjust the pH to about 9.0, and reflux extraction twice at 70°C, each extraction time is about 1.5h, Obtain the alcohol extract of the stems and branches of Cotinus chinensis, concentrate under reduced pressure by rotary evaporation, evaporate to dryness in a water bath, and obtain the extract of alcohol extract;

[0045] 3> Macroporous resin decolorization and impurity removal treatment: dissolve the alcohol extract extract in 50% ethanol, apply D101 macroporous resin (Shanghai Resin Factory, China), elute with 95% ethanol with a column volume of abo...

Embodiment 2

[0057] The separation and purification process 2 of fisetin and myricetin in the sumac sumac in embodiment 2

[0058] 1> Processing of raw materials: take the stems and branches of sumac sumac, cut them into slices, dry them in the sun, crush them into powder, and set them aside;

[0059] 2> Reflux extraction: Take 20g of dry sumac stem powder, use about 70% ethanol equivalent to about 20 times the amount of dry sumac dry powder, adjust the pH to about 9.0, and reflux extraction twice at 70°C, each extraction time is about 1.5h, Obtain the alcohol extract of the stems and branches of Cotinus chinensis, concentrate under reduced pressure by rotary evaporation, evaporate to dryness in a water bath, and obtain the extract of alcohol extract;

[0060] 3> Macroporous resin decolorization and impurity removal treatment: dissolve the alcohol extract extract in 50% ethanol, apply D101 macroporous resin (Shanghai Resin Factory, China), elute with 95% ethanol with a column volume of abo...

Embodiment 3

[0063] The separation and purification process 3 of fisetin and myricetin in the sumac sumac in embodiment 3

[0064] 1> Processing of raw materials: take the stems and branches of sumac sumac, cut them into slices, dry them in the sun, crush them into powder, and set them aside;

[0065] 2> Reflux extraction: Take 20g of dry sumac stem powder, use about 70% ethanol equivalent to about 20 times the amount of dry sumac dry powder, adjust the pH to about 9.0, and reflux extraction twice at 70°C, each extraction time is about 1.5h, Obtain the alcohol extract of the stems and branches of Cotinus chinensis, concentrate under reduced pressure by rotary evaporation, evaporate to dryness in a water bath, and obtain the extract of alcohol extract;

[0066] 3> Macroporous resin decolorization and impurity removal treatment: dissolve the alcohol extract extract in 50% ethanol, apply D101 macroporous resin (Shanghai Resin Factory, China), elute with 95% ethanol with a column volume of abo...

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Abstract

The invention provides a method of separating and extracting fisetin and myricetin in cotinus coggygria simultaneously. The method is simple in process route, comprises few steps and can separate andextract fisetin and myricetin simultaneously specifically and efficiently. The invention provides a pharmaceutical composition, a food additive composition and a cosmetics composition containing the cotinus coggygria extract prepared by the method.

Description

technical field [0001] The invention belongs to the field of purification, preparation and application of traditional Chinese medicines. Specifically, the present invention relates to a preparation method and application thereof for simultaneously extracting fisetin and myricetin from cotinus sumac. Background technique [0002] Sumac (Cotinus coggygria scop.) is a plant of the genus Cotinus L. in the family Anacardiaceae. Cotinus sumac is used as medicine with roots, branches and leaves; it is cool in nature and bitter in taste. It has the effects of clearing away heat and detoxification, dissipating blood stasis and relieving pain. Although the plant has not entered the Chinese Pharmacopoeia as a medicinal material, many pharmacodynamic experiments in recent years have shown that it has antibacterial, anti-hepatitis and anti-fatigue effects. [0003] Sumac contains flavonoids, polysaccharides, trace elements, amino acids and other functional ingredients, which have the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40A61K8/49A61Q19/08A61K31/352A61P35/00A23L33/10
CPCA23L33/10A23V2002/00A61K8/498A61K31/352A61P35/00A61Q19/08C07D311/30C07D311/40A61K2300/00A23V2250/2116
Inventor 王刚
Owner 王刚
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