The invention discloses a compound cotinus coggygria zinc oral solution and a preparation method thereof. The oral solution is mainly prepared from main materials and auxiliary materials, wherein the main materials include the following ingredients: zinc supplement, root of cotinus coggygria, star jasmine fruit, vitis flexuosa thunb, capsellae bursapastoris, fruit of gastrodiaelata, fruit of schisandra lancifolia, grewia biloba, lespedeza tomentosa and aralia elata; and the auxiliary materials include the following ingredients: hard bluegrass culm and leaves, vaccinium bracteatum, matsutake, iris dacora wall, gmelin sealavender herb, coix leaves, lysine, asparaginic acid, oryzanol, laurate, taurine, multivitamins, ferrous lactate and a flavoring agent. The compound cotinus coggygria zinc oral solution is simple in preparation process, low in cost and convenient to take, has the effects of strengthening tendons and bones, activating blood circulation to relieve pain, strengthening spleen, tonifying qi, nourishing qi and blood and enhancing immunity, and can be used for supplying calcium, zinc, vitamins, amino acids and other nutritional substances, comprehensively regulating and improving the body condition of a patient, increasing bone density and strength, promoting rehabilitation of injured bones and promoting healthy growth of children.