Filling method of almagate suspension

A suspension, aluminum-magnesium plus technology, applied in the field of pharmaceuticals, can solve problems such as stickiness, difficulty in filling and sealing precise control of filling volume, and achieve the effects of accurate filling volume, not easy to leak, and high strength

Inactive Publication Date: 2019-03-01
YANGZHOU YIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In the prior art, the suspension-type medicine is often relatively viscous, which makes it difficult to fill and seal during the production process, especially to accurately control the filling volume. Therefore, it is urgent to invent a method to solve the above technical problems

Method used

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  • Filling method of almagate suspension
  • Filling method of almagate suspension
  • Filling method of almagate suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Filling of aluminum and magnesium suspension

[0028] (1) Move the feed liquid from the storage tank to the small storage tank;

[0029] (2) Open the potting and sealing machine, and the feed liquid passes through the initial feed liquid 6L of the filling port of the potting and sealing machine to be discarded;

[0030] (3) After confirming that the vertical and horizontal heating temperature of the sealing part in the filling and sealing machine reaches 160°C, turn on the ultraviolet lamp inside the machine, put the aluminum-plastic composite film into the pressure roller, and turn on the compressed air cooling device at the same time;

[0031] (4) Confirm that the length, bonding firmness, and indentation line of the aluminum-plastic composite film bag meet the regulations;

[0032] (5) Detect the relative density ρ of feed liquid, calculate the filling capacity of every bag of medicinal liquid according to the following formula: M=ρ*V; Wherein V is 15mL;

[0033] (...

Embodiment 2

[0037] Filling of aluminum and magnesium suspension

[0038] (1) Move the feed liquid from the storage tank to the small storage tank;

[0039] (2) Open the potting and sealing machine, and the feed liquid passes through the initial feed liquid 6L of the filling port of the potting and sealing machine to be discarded;

[0040] (3) After confirming that the vertical and horizontal heating temperature at the sealing part of the filling and sealing machine reaches 200°C, turn on the ultraviolet lamp inside the machine, put the aluminum-plastic composite film into the pressure roller, and turn on the compressed air cooling device at the same time;

[0041] (4) Confirm that the length, bonding firmness, and indentation line of the aluminum-plastic composite film bag meet the regulations;

[0042] (5) Detect the relative density ρ of feed liquid, calculate the filling capacity of every bag of medicinal liquid according to the following formula: M=ρ*V; Wherein V is 15mL;

[0043] (...

Embodiment 3

[0048] Filling of aluminum and magnesium suspension

[0049] (1) Move the feed liquid from the storage tank to the small storage tank;

[0050] (2) Open the potting and sealing machine, and the feed liquid passes through the initial feed liquid 6L of the filling port of the potting and sealing machine to be discarded;

[0051] (3) After confirming that the vertical and horizontal heating temperature at the sealing part of the filling and sealing machine reaches 180°C, turn on the ultraviolet lamp inside the machine, put the aluminum-plastic composite film into the pressure roller, and turn on the compressed air cooling device at the same time;

[0052] (4) Confirm that the length, bonding firmness, and indentation line of the aluminum-plastic composite film bag meet the regulations;

[0053] (5) Detect the relative density ρ of feed liquid, calculate the filling capacity of every bag of medicinal liquid according to the following formula: M=ρ*V; Wherein V is 15mL;

[0054] (...

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Abstract

The invention relates to a filling method of an almagate suspension. The filling method of the almagate suspension comprises the following steps of (1) moving a feed liquid from a storage tank to a small storage tank; (2) opening a filling and sealing machine, 6 L of primary feed liquid passing through a filling port of the filling and sealing machine is abandoned; (3) after confirming that the vertical and horizontal heating temperature of a sealing port of the filling and sealing machine reaches 160 DEG C-200 DEG C, turning on an ultraviolet lamp which is arranged inside the machine; (4) confirming that the length, adhesion firmness and indentation lines of an aluminum-plastic composite film bag conform with the regulations; (5) calculating the filling quantity of each bag of liquid according to the following formula: M=rho*V, wherein the V is 15 mL; and (6) carrying out filling. The bagged almagate suspension prepared by the filling method of the almagate suspension has accurate filling capacity, and packaging bags are high in strength, not prone to leakage and convenient to store and transport.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a filling method of aluminum-magnesium plus suspension. Background technique [0002] Almagate Suspension (Almagate Suspension) is a drug approved for marketing in the People's Republic of China, which is a drug for neutralizing gastric acid. The quality control of the aluminum-magnesium plus suspension is carried out in accordance with the national drug standard YBH05852018 of the Food and Drug Administration of the People's Republic of China. [0003] In the prior art, every 15ml of aluminum-magnesium suspension contains 1.5g of aluminum-magnesium suspension. [0004] Aluminum magnesium plus (Almagate), its chemical name is: fourteen hydroxy aluminum magnesium carbonate hydrate. Molecular formula: Al2Mg6(OH)14(CO3)2·4H2O. Molecular weight: 630.02. [0005] Aluminum-magnesium plus is an antacid with fast action and strong ability to neutralize gastric acid, which can maint...

Claims

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Application Information

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IPC IPC(8): B65B51/26B65B51/32B65B3/26B65B3/34B65B55/08B65B57/02
CPCB65B51/26B65B3/26B65B3/34B65B51/32B65B55/08B65B57/02
Inventor 党高全陈亚舟
Owner YANGZHOU YIYANG PHARMA
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