Method for treating tumor

A tumor and pharmaceutical technology, applied in the field of tumor treatment, can solve the problems of insufficient efficacy, time-consuming, expensive, etc.

Inactive Publication Date: 2019-03-01
JOHNPRO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these strategies have limitations such as being expensive, ineffective and / or time consuming

Method used

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  • Method for treating tumor
  • Method for treating tumor
  • Method for treating tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 AM radiofrequency radiation can increase the absorption of cells to liposome-coated drugs

[0098] This example will investigate the effect of AM radiofrequency radiation on the phagocytosis or absorption of liposome-coated drugs (ie, lipo-dox). According to the materials and methods, HepG2 cells were first administered with lipo-dox, and then irradiated with AM radiofrequency radiation. Analyzed by flow cytometry and confocal microscope, Figures 1A-1B The results of these analyzes are described separately.

[0099] All treatment groups (ie groups treated with 37°C, 42°C or mEHT) increased tissue uptake of lipo-dox compared to the control group. Notably, the fluorescence signal of cells treated with mEHT was higher than that of cells treated at 37°C or 42°C (results not shown). During mEHT treatment, the cell temperature was maintained at around 37°C or 42°C, and the effect of mEHT on increasing uptake was observed at both temperatures. There was no signif...

Embodiment 2

[0102] Example 2 The Mechanism of mEHT Increased Absorption Efficacy

[0103] Cells are known to take up molecules of different particle sizes through different pathways; for example, cells can utilize macropinocytosis, clathrin-mediated endocytosis, and caveolae-mediated endocytosis Phytocytosis (Caveolae-mediated endocytosis) to absorb particles with diameters of 0.5-55 microns, 50 nanometers and 100 nanometers, respectively.

[0104] In this example, polydextrose (about 0.5-5 microns), CT-B (about 100 nanometers) or transferrin (about 50 nanometers) was administered to HepG2 cells first, and then flow cytometry was used to analyze the results. In order to understand the relevant mechanism of the increased absorption efficacy of mEHT observed in Example 1. Figures 2A-2C These results are presented separately.

[0105] like Figure 2A As shown, compared with the control group (ie, untreated cells), all treatments (ie, 37°C, 42°C, and mEHT treatment) can increase the uptak...

Embodiment 3

[0108] Example 3 mEHT increases the absorption of lipo-dox by the living body

[0109] This example will utilize animal models to evaluate the efficacy of mEHT on drug absorption. image 3 The results indicated that mice treated with mEHT had a higher amount of emycin in their tumors compared to mice treated with water bath (WB) and control mice.

[0110] To sum up the above, the present invention provides a method for effectively improving the absorption of liposome-coated drugs by tumor cells, which is achieved by administering AM radiofrequency radiation to tumors to achieve the effect of increasing absorption. Thus, the present disclosure provides a safe and effective treatment strategy for individuals suffering from solid tumors.

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Abstract

A method of treating a subject having or suspected of having a solid tumor, comprises administering to the subject an effective amount of a liposome-encapsulated drug, and applying an amplitude-modulated (AM) radiofrequency radiation to the solid tumor.

Description

technical field [0001] The present invention relates to the field of treating tumors. More specifically, the present invention relates to the use of liposomes and amplitude-modulated (AM) radiofrequency radiation in the treatment of tumors. Background technique [0002] Cancer is a common fatal disease, and about 14 million patients are diagnosed with cancer every year; World Health Organization (WHO) World Cancer Report in 2014 further pointed out that tumors cause about 820 million people a year. Thousands of people died. So far, various methods for treating tumors have been developed in related fields, such as surgery, chemotherapy, radiation therapy, anti-angiogenesis therapy, and immunotherapy. However, these treatments still do not provide sufficient therapeutic benefit. [0003] Liposomes are spherical vesicles with at least one lipid bilayer structure. Liposomes can be used as a carrier for coating and delivering nutrients or medicines, so as to deliver nutrients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/40
CPCA61N1/40A61K31/704A61P35/00A61K9/0019A61K9/127A61N1/403A61N5/10
Inventor 季匡华王愈善江欣蒨黃正忠
Owner JOHNPRO BIOTECH
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