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Molecularly imprinted polymer with reversible covalent binding function and preparation method and application of molecularly imprinted polymer

A molecular imprinting and covalent binding technology, applied in the analysis of materials, material analysis by electromagnetic means, instruments, etc., can solve the problems of practicability and simple methods that have not yet been reported, and achieve stable template-monomer structure, good effect, Strong binding effect

Active Publication Date: 2019-03-08
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a practical and simple method for DA quantification has not been reported

Method used

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  • Molecularly imprinted polymer with reversible covalent binding function and preparation method and application of molecularly imprinted polymer
  • Molecularly imprinted polymer with reversible covalent binding function and preparation method and application of molecularly imprinted polymer
  • Molecularly imprinted polymer with reversible covalent binding function and preparation method and application of molecularly imprinted polymer

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Embodiment 1

[0032] like figure 1 The present invention discloses a method for preparing a molecularly imprinted polymer with a reversible covalent binding function, and the steps of the method are as follows:

[0033] Synthesis of covalent-MIPs: template DA1mmol, functional monomer 4-vinylphenylboronic acid (VPBV) 2mmol, crosslinker ethylene glycol dimethacrylate (EGDMA) 2mmol and free radical initiator AIBN25mg were dissolved in acetonitrile (25mL) and DMF (15mL). The mixture was sonicated for 10 min to maintain homogeneity. Then use mild N 2 The solution was purged with air flow for 15 minutes and the 2 Seal under atmosphere. Finally, the flask was immersed in an oil bath at 70°C for 24 hours for polymerization.

[0034] Membrane plate removal: The template was removed by alternating solvent extraction with methanol / acetic acid (8 / 2, v / v) and hydrochloric acid solution (pH=2). Complete template removal was confirmed by ultraviolet absorption spectroscopy (UV). The resulting polym...

Embodiment 2

[0043] Synthesis of covalent-MIPs: template DA (1 mmol), functional monomer VPBV (2 mmol), EGDMA (10 mmol) and free radical initiator AIBN (20 mg) were dissolved in acetonitrile (45 mL) and DMF (15 mL). The mixture was sonicated for 10 min to maintain homogeneity. then use N 2 The solution was purged with gas for 15 min and the 2 Seal under atmosphere. Finally, the flask was immersed in an oil bath at 70°C for 24 hours for polymerization.

[0044] Membrane plate removal: The template was removed by solvent extraction in batch mode with methanol / acetic acid (8 / 2, v / v) and hydrochloric acid solution (pH=2). Complete template removal was confirmed by ultraviolet absorption spectroscopy (UV). The resulting polymer was then vacuum dried overnight at 40°C.

[0045] Wherein, the synthetic method of covalent-MIPs is as follows:

[0046] Template DA (1 mmol), functional monomer VPBV (2 mmol), EGDMA (10 mmol) and radical initiator AIBN (20 mg) were dissolved in acetonitrile (45 mL...

Embodiment 3

[0048] Synthesis of covalent-MIPs: template DA (1 mmol), functional monomer VPBV (2 mmol), EGDMA (10 mmol) and free radical initiator AIBN (20 mg) were dissolved in acetonitrile (45 mL) and DMF (15 mL). The mixture was sonicated for 10 min to maintain homogeneity. then use N 2 The solution was purged with gas for 15 min and the 2 Seal under atmosphere. Finally, the flask was immersed in an oil bath at 80°C for 24 hours for polymerization.

[0049] Membrane plate removal: The template was removed by solvent extraction in batch mode with methanol / acetic acid (8 / 2, v / v) and hydrochloric acid solution (pH=2). Complete template removal was confirmed by ultraviolet absorption spectroscopy (UV). The resulting polymer was then vacuum dried overnight at 40°C.

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Abstract

The invention discloses a molecularly imprinted polymer with a reversible covalent binding function and a preparation method and application of the molecularly imprinted polymer. The preparation method comprises the following steps: introducing covalent bonds in a molecularly imprinted polymers (MIPs) system by taking dopamine (DA) as a template and taking 4- vinylbenzeneboronic acid (VPBV) as functional monomers, and self-assembling the covalent bonds with a crosslinking agent and an initiator to form a covalent imprinted polymer; and adjusting the pH value of the environment to be acidic toenable covalent bonds to be broken, and separating the DA template from MIPs to form a cavity of which the shape is complementary to the 3D shape of DA. When pH is greater than 5, boracic acid of VPBVcan be covalent bound to vicinal diol of DA again, and thus, a DA recognition function is fulfilled. Advantages of a molecularly imprinted space structure and affinity of borate are combined, and DAdetection selectivity and sensitivity are improved. Remarkably improved sensitivity is provided for DA detection, the molecularly imprinted polymer can be recycled, the cost is saved, the molecularlyimprinted polymer is non-toxic and harmless, and thus, it shows that the molecularly imprinted polymer is a promising DA analyzing method.

Description

technical field [0001] The invention relates to the technical field of material chemistry, in particular to a molecularly imprinted polymer with reversible covalent binding function and its preparation method and application. Background technique [0002] As ideal artificial chemical receptors, molecularly imprinted polymers (MIPs) have become predictable, specific recognizable, and general materials based on their molecularly imprinted special structures. But it should be noted that conventional MIPs are fabricated by functional monomer molecules and template molecules through non-covalent interactions, such as hydrogen bonds, van der Waals forces and static attraction. It should be noted that the structural consistency of non-covalently bound monomer-template conjugates in the prepolymers cannot be guaranteed and nonspecificity arises due to the random grafting of functional monomers and crosslinkers into the polymer matrix. Binding sites are often unstable, resulting in ...

Claims

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Application Information

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IPC IPC(8): C08F230/06C08F222/14C08J9/26G01N27/327G01N33/543
CPCC08F222/1006C08F230/06C08J9/26C08J2335/02C08J2343/00C08F222/102G01N27/3275G01N33/5438G01N33/54386
Inventor 王瑶邢丽唐建国刘继宪黄林军王彦欣王薇李浩王筵棋
Owner QINGDAO UNIV
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