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Composition for removing skin spots as well as preparation method and application of composition

A composition and stain technology, applied in the field of daily chemicals, can solve problems such as limited application, easy oxidation and deterioration, and unstable chemical properties, and achieve the effects of brightening the skin, low cost, and inhibiting the formation of melanin

Inactive Publication Date: 2019-03-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Arbutin has many good biological activities, but due to the presence of multiple water-soluble phenolic hydroxyl groups in the molecular structure, its chemical properties are unstable and easily oxidized and deteriorated, which limits its application as an antioxidant in oil products

Method used

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  • Composition for removing skin spots as well as preparation method and application of composition
  • Composition for removing skin spots as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Composition of raw materials (parts by weight): 50 parts of arbutin solid lipid nanoparticles freeze-dried powder, 10 parts of plantago, 10 parts of peony, 10 parts of licorice, 15 parts of rutin, 5 parts of green tea, 5 parts of Sophora japonica, Hazel 15 parts, paeonol 15 parts, grape seed extract 3 parts, chamomile extract 5 parts, L-ascorbic acid 3 parts, catechin 1 part, glycerin 10 parts, sunscreen 5 parts, pearl powder 6 parts, Tween -801 parts and 1 part disodium EDTA.

[0026] The sunscreen is oligomeric proanthocyanidins.

[0027] The arbutin solid lipid nanoparticle freeze-dried powder is prepared by the following method: 1g arbutin, 6g palmitate and 2g egg yolk lecithin are dissolved in 50mL ethyl acetate, and the water bath is to 80°C, and all of them are dissolved as For the organic phase, dissolve F68 in ultrapure water as the water phase, stir at 800r / min, slowly inject the organic phase into the water phase with a No. 5 needle, and quickly disperse in ...

Embodiment 2

[0033] Composition of raw materials (parts by weight): 80 parts of arbutin solid lipid nanoparticles freeze-dried powder, 20 parts of plantago, 20 parts of peony, 20 parts of licorice, 25 parts of rutin, 10 parts of green tea, 15 parts of Sophora japonica, 20 parts of hazel, 20 parts of paeonol, 5 parts of grape seed extract, 12 parts of chamomile extract, 8 parts of L-ascorbic acid, 3 parts of catechin, 20 parts of glycerin, 10 parts of sunscreen, 9 parts of pearl powder, Tween -807 parts and 4 parts disodium EDTA.

[0034] The sunscreen is aminobenzoic acid anti-ultraviolet agent.

[0035] The arbutin solid lipid nanoparticle freeze-dried powder is prepared by the following method: 1g arbutin, 6g palmitate and 2g egg yolk lecithin are dissolved in 50mL ethyl acetate, and the water bath is to 85°C, and all of them are dissolved as For the organic phase, dissolve F68 in ultrapure water as the water phase, stir at 1000r / min, slowly inject the organic phase into the water phase w...

Embodiment 3

[0041] Composition of raw materials (parts by weight): 60 parts of arbutin solid lipid nanoparticles freeze-dried powder, 12 parts of plantago, 13 parts of peony, 12 parts of licorice, 16 parts of rutin, 6 parts of green tea, 7 parts of Sophora japonica, 17 parts of hazel plum, 16 parts of paeonol, 3 parts of grape seed extract, 7 parts of chamomile extract, 4 parts of L-ascorbic acid, 1 part of catechin, 13 parts of glycerin, 6 parts of sunscreen, 6 parts of pearl powder, Tween -802 parts and 1 part disodium EDTA.

[0042] The sunscreen is p-methyl cinnamate.

[0043] The arbutin solid lipid nanoparticle freeze-dried powder is prepared by the following method: 1g arbutin, 6g palmitate and 2g egg yolk lecithin are dissolved in 50mL ethyl acetate, and the water bath is to 81°C, and all of them are dissolved as For the organic phase, dissolve F68 in ultrapure water as the water phase, stir at 850r / min, slowly inject the organic phase into the water phase with a No. 5 needle, an...

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Abstract

The invention provides composition for removing skin spots. The composition is prepared from raw materials in parts by weight as follows: 50-80 parts of lyophilized powder of arbutin solid nanoparticles, 10-20 parts of semen plantaginis, 10-20 parts of radix paeoniae, 10-20 parts of radix glycyrrhizae, 15-25 parts of rutin, 5-10 parts of green tea, 5-15 parts of flos sophorae, 15-20 parts of radixhamamelis, 15-20 parts of cortex moutan, 3-5 parts of grape seed extract, 5-12 parts of chamomile extract, 3-8 parts of L-ascorbic acid, 1-3 parts of catechin, 10-20 parts of glycerin, 5-10 parts ofa sun-screening agent, 6-9 parts of pearl powder, 1-7 parts of tween-80 and 1-4 parts of EDTA-2Na. The raw materials are simple and easily available, the cost is low, a preparation method is simple, the application effect is good, spots can be removed obviously, the effects of sun screening, skin whitening and moisturizing to a certain degree can be realized, healthy color of the skin is protected, and the composition is popular with customers.

Description

technical field [0001] The invention relates to the technical field of daily chemicals, in particular to a composition for removing skin spots and a preparation method thereof. Background technique [0002] Plant polyphenols, also known as tannin, are commonly found in flowering plants and belong to secondary metabolites, mainly distributed in all vegetative organs of plants such as flowers and fruits. They also widely exist in fruits, vegetables, grains and beverages, and are closely related to human life and health. Fruits such as grapes, apples, pears, cherries and berries contain up to 200 to 300 mg of polyphenols per 100 g of fresh weight. Plant polyphenols have a polyphenolic structure and are mainly involved in the chemical defense of plants and the anti-interference effect of plants. In addition, studies in recent years have shown that plant polyphenols also exhibit good physiological activities such as anti-oxidation, whitening, lightening, anti-inflammatory, anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/49A61K8/60A61K8/67A61K8/9789A61K8/11A61Q17/04A61Q19/02A61Q19/08
CPCA61K8/11A61K8/498A61K8/602A61K8/676A61K8/987A61K2800/5922A61K2800/84A61Q17/04A61Q19/02A61Q19/08A61K8/9789
Inventor 姜丽艳张艳董洪举李雅静李雨航苏丰
Owner JILIN UNIV
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