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Anticancer agent, radiosensitizer, and food composition

A technology of sensitizer and radiation, which is applied in radiation-sensitizing materials, food science, drug combination, etc., can solve problems such as low nutrition, anticancer agents and radiation are difficult to exert their effectiveness, and the effect of radiation therapy is reduced, so as to achieve enhanced effect, Enhance the anti-tumor effect and prolong the effect of survival rate

Active Publication Date: 2019-03-15
KRACIE SEIYAKU +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is one reason radiation therapy is less effective
[0009] It has been reported that in various cancers, especially pancreatic cancer, the cancer microenvironment is low in oxygen and nutrition, and it is difficult for conventional anticancer agents and radiation to exert their effectiveness

Method used

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  • Anticancer agent, radiosensitizer, and food composition
  • Anticancer agent, radiosensitizer, and food composition
  • Anticancer agent, radiosensitizer, and food composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Arctium aglycone-containing burdock root extract was prepared by the following method.

[0082] The burdock seeds (enzymatic activity 7.82 U / g) were cut, and the whole was passed through a sieve of 9.5 mm, and then passed through a sieve of 0.85 mm, and it was confirmed that 75% remained. 80 kg of the burdock pieces were added to 560 L of water kept at 30-32° C., stirred for 30 minutes, then 253 L of ethanol was added, the temperature was raised to 85° C., and the mixture was heated and refluxed for 40 minutes. This liquid was centrifuged to obtain the obtained extract. This operation was repeated twice, the obtained extracts were combined and concentrated under reduced pressure, and 25% of dextrin was added to the solid content of the extract, followed by spray drying. The contents of arctigenin and arctiin were 6.4% and 7.2%, respectively, to obtain arctigenin / arctiin (weight ratio)=0.89 arctigenin extract powder (containing dextrin 25%).

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Abstract

Provided are an anticancer agent, radiosensitizer, and food composition capable of heightening the effects of radiation therapy. The present inventors discovered that tumors shrink significantly in comparison to an untreated group and the respective monotherapy groups when treatment by burdock extract containing arctigenin and radiation therapy were used in combination on mice transplanted with human pancreatic cancer cells. The anticancer agent of the present invention is an anticancer agent containing arctigenin and / or arctiin as the active ingredient, to be used in combination with radiation therapy. The arctigenin and / or arctiin may be contained as burdock, burdock fruit, burdock sprout, or forsythia, or an extract extracted from these.

Description

technical field [0001] The present invention relates to an anticancer agent for use in combination with radiation therapy, a radiation sensitizer, and a food composition for enhancing the effect of radiation therapy. Background technique [0002] The three main types of cancer treatment are "surgery", "anticancer drug therapy" and "radiation therapy". One of the newer treatments is "radiation therapy". Radiation therapy is a method of exterminating cancer cells by irradiating them with radiation such as X-rays, γ-rays, and electron beams. Radiation can damage the DNA in cancer cells, causing the division of cancer cells to stop and cell apoptosis. In addition, radiation activates oxygen in cells to form active oxygen, thereby enhancing the DNA lethality. The advantages of radiation therapy include no surgical excision of tissue, ability to perform local treatment, and minimal damage to normal tissues. Combination therapy with anticancer agents and radiation is often perf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A23L33/105A61K31/7048A61K36/28A61K36/634A61P35/00A61P43/00
CPCA61K31/365A61K31/7048A61K36/28A61K36/634A23L33/105A61P35/00A61P43/00A61K41/0038A61N2005/1098A23L29/035
Inventor 江角浩安土原一哉川岛孝则
Owner KRACIE SEIYAKU
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