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Preparation method of long-chain alkane quaternization antibacterial agent, and product and application of antibacterial agent

A long-chain alkane, quaternary ammonium technology, applied in the directions of botanical equipment and methods, applications, fungicides, etc., can solve the problem of undisclosed effective antibacterial preparation methods of quaternized antibacterial agents, achieve good bactericidal effect, enhance The effect of killing

Inactive Publication Date: 2019-03-22
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the effective antibacterial methods for the above bacterial species are mostly antibiotics, and the effective antibacterial preparation methods based on quaternized ammonium antibacterial agents have not yet been disclosed.

Method used

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  • Preparation method of long-chain alkane quaternization antibacterial agent, and product and application of antibacterial agent
  • Preparation method of long-chain alkane quaternization antibacterial agent, and product and application of antibacterial agent
  • Preparation method of long-chain alkane quaternization antibacterial agent, and product and application of antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 10 g of polyethyleneimine with a molecular weight of 1800 Daltons and 0.11 g of brominated octane (the molar ratio of polyethyleneimine and brominated octane is 10:1) to 50 mL of acetonitrile solution, and stir at room temperature for 24 hours. After routine purification and drying, the quaternized antibacterial agent 1 was obtained.

Embodiment 2

[0030] Add 5g of poly 2-(dimethylamino)ethyl methacrylate with a molecular weight of 20000 Daltons and 0.03g of tridecane chloride (poly 2-(dimethylamino)ethyl methacrylate and The molar ratio of tridecane chloride is 1:1), and after stirring at room temperature for 72 hours, it was routinely purified and dried to obtain quaternized ammonium antibacterial agent 2.

Embodiment 3

[0032] Add 5 g of poly-2-(dimethylamino) ethyl acrylate and 0.02 g of iodohexadecane (poly-2-(dimethylamino) ethyl acrylate and iodide hexadecane) into 20 mL of THF solution The molar ratio of alkane is 100:1), after stirring at room temperature for 36 hours, it is purified and dried conventionally to obtain quaternized antibacterial agent 3.

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Abstract

The invention relates to a preparation method of a long-chain alkane quaternization antibacterial agent, and a product and application of the antibacterial agent. Long-chain haloalkane is modified ona polymer richly containing tertiary amine; the carbon number on alkyl of the long-chain haloalkane is not smaller than 7. The prepared antibacterial agent has an excellent antibacterial effect on staphylococcus aureus, escherichia coli, candida albicans, helicobacter pylori, pseudomonas aeruginosa, aspergillus flavus and listeria monocytogenes; in the concentration dose with the antibacterial effect, cytotoxicity cannot be generated; the biological safety is realized. The preparation method is safe and simple and can be applied to industrial production; the development and application have development prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of a long-chain alkane quaternized antibacterial agent and its product and application. Background technique [0002] At present, with the enhancement of people's safety and health awareness, the demand for high-efficiency antibacterial agents is more urgent. In the current industrial application of antibacterial, it is mainly through the input of small molecule antibacterial agents such as quaternary ammonium salt antibacterial agents, zinc oxide and silver oxide. However, small molecule antibacterial agents have many disadvantages such as difficult processing, poor chemical stability and high toxicity. Polymer antibacterial agents can well overcome the above shortcomings. Smaller molecular antibacterial agents, polymer antibacterial agents have good stability and non-dissolution, and have high biological safety. The generally accepted antibacterial mecha...

Claims

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Application Information

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IPC IPC(8): C08G73/04C08F8/32C08F120/34C08F120/60A23B4/20A01N33/12A01N37/44A01P1/00A01P3/00
CPCA01N33/12A01N37/44A23B4/20C08F8/32C08G73/02C08F120/34C08F120/60
Inventor 徐福建宋洁李杨胡杨
Owner BEIJING UNIV OF CHEM TECH
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