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A kind of carboxyethyl chitosan/polyvinyl alcohol self-healing hydrogel and its preparation method and application

A technology of carboxyethyl chitosan and polyvinyl alcohol, which is applied in the field of biomedical materials, can solve the problems of brittle and easily broken chitosan-based hydrogels, and achieve improved hydrophilicity, enhanced mechanical strength, and balance Significant effect of water content

Active Publication Date: 2021-03-16
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to solve the problems such as existing chitosan-based hydrogel quality is brittle, easily broken, and a kind of novel carboxyethyl chitosan / polyvinyl alcohol self-healing hydrogel is provided, and this hydrogel has Excellent self-healing ability, swelling performance, equilibrium water content, pH response and mechanical properties, and parameters such as degradability, equilibrium water content, gel time and swelling property can be flexibly adjusted

Method used

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  • A kind of carboxyethyl chitosan/polyvinyl alcohol self-healing hydrogel and its preparation method and application
  • A kind of carboxyethyl chitosan/polyvinyl alcohol self-healing hydrogel and its preparation method and application
  • A kind of carboxyethyl chitosan/polyvinyl alcohol self-healing hydrogel and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Such as figure 1 Shown, a kind of preparation method of carboxyethyl chitosan / polyvinyl alcohol self-healing hydrogel, concrete process is as follows:

[0026] (1) Dissolve 1.0g of polyvinyl alcohol in 30mL of water at 90°C, keep the temperature of the solution at 90°C, then add 1.0g of carboxyethyl chitosan to it, and continue stirring to completely dissolve the solid to obtain carboxyethyl chitosan Polysaccharide / polyvinyl alcohol complex solution. Wherein, the total concentration of carboxyethyl chitosan and polyvinyl alcohol is 67g / L.

[0027] (2) Dissolve accurately measured oxidized sodium alginate and boric acid in 10 mL of water to prepare a mixed crosslinking agent solution, wherein the concentration of oxidized sodium alginate is 100.0 g / L, and the concentration of boric acid is 2.0 g / L.

[0028] (3) Add 200 μL of mixed crosslinking agent solution to 5 mL of carboxyethyl chitosan / polyvinyl alcohol composite solution, stir quickly and evenly, and raise the te...

Embodiment 2

[0030] (1) Dissolve 1.0g of polyvinyl alcohol in 30mL of water at 90°C, keep the temperature of the solution at 90°C, then add 1.0g of carboxyethyl chitosan to it, and continue stirring to completely dissolve the solid to obtain carboxyethyl chitosan Polysaccharide / polyvinyl alcohol complex solution. Wherein, the total concentration of carboxyethyl chitosan and polyvinyl alcohol is 67g / L.

[0031] (2) Dissolve oxidized sodium alginate and boric acid in 10 mL of water to prepare a mixed crosslinking agent solution, wherein the concentration of oxidized sodium alginate is 100.0 g / L, and the concentration of boric acid is 2.0 g / L.

[0032] (3) Add 500 μL of mixed cross-linking agent solution to 5 mL of carboxyethyl chitosan / polyvinyl alcohol composite solution, stir quickly and evenly, and raise the temperature of the reaction solution to 30 ° C for 24 hours at a constant temperature to obtain carboxyethyl chitosan / Polyvinyl alcohol self-healing hydrogel.

[0033] According t...

Embodiment 3

[0040] (1) Dissolve 1.0g of polyvinyl alcohol in 30mL of water at 90°C, keep the temperature of the solution at 90°C, then add 1.0g of carboxyethyl chitosan to it, and continue stirring to completely dissolve the solid to obtain carboxyethyl chitosan Polysaccharide / polyvinyl alcohol complex solution. Wherein, the total concentration of carboxyethyl chitosan and polyvinyl alcohol is 67g / L.

[0041] (2) Dissolve oxidized sodium alginate and boric acid in 10 mL of water to prepare a mixed crosslinking agent solution, wherein the concentration of oxidized sodium alginate is 100.0 g / L, and the concentration of boric acid is 2.0 g / L.

[0042] (3) Add 100 μL of mixed cross-linking agent solution to 5 mL of carboxyethyl chitosan / polyvinyl alcohol composite solution, stir quickly and evenly, raise the temperature of the reaction solution to 30° C. and react at a constant temperature for 24 hours to obtain carboxyethyl chitosan / Polyvinyl alcohol self-healing hydrogel.

[0043] An eq...

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Abstract

The invention relates to carboxyethyl chitosan / polyvinyl alcohol self-healing hydrogel as well as a preparation method and application thereof, aiming at mainly solving the problems that the texture of existing chitosan-based hydrogel is relatively fragile and easy to break, and the safety of a used biological crosslinking agent is not good enough and the like. The hydrogel takes carboxyethyl chitosan as a base material; after the carboxyethyl chitosan is blended with polyvinyl alcohol, an oxidized sodium alginate-boric acid compound crosslinking agent is used for carrying out crosslinking toconstruct a novel multi-crosslinking network structure; the hydrogel has the advantages of excellent self-sealing performance, swelling performance, balanced moisture content, pH (Potential of Hydrogen) responsiveness and mechanical properties; and parameters including the degradability, the balanced moisture content, gel time, the swelling performance and the like can be flexibly regulated and controlled, so that the hydrogel can meet the requirements of different application scenes and applications.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a carboxyethyl chitosan / polyvinyl alcohol self-healing hydrogel and a preparation method and application thereof. Background technique [0002] Hydrogels are widely used in fields such as medicine, tissue engineering and agriculture. Common hydrogel materials are usually accompanied by fracture or breakage during use, which will seriously affect their performance and greatly shorten the service life of the material. Self-healing hydrogel refers to a type of hydrogel that can self-repair after being damaged (broken or damaged), and its performance can be completely restored or restored to a state close to the state before the self-repair. On the one hand, the self-healing hydrogel can prolong the service life of the material. On the other hand, because the hydrogel contains a large amount of water, which is similar to biological tissue, it can still self-heal after b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L29/04
CPCC08J3/075C08J3/243C08J2305/08C08J2429/04
Inventor 何广华赵洒柴赟曹继龙王程
Owner WUHAN UNIV OF TECH
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