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Method for preparing high-density boric acid site adsorbent based on supramolecular interface assembly strategy

A supramolecular and high-density technology, applied in chemical instruments and methods, and other chemical processes, can solve the problems of slow speed, functional monomer embedding, and low adsorption efficiency, so as to increase adsorption capacity, enhance adsorption selectivity, good stability effect

Active Publication Date: 2019-03-29
合肥九州龙腾科技成果转化有限公司
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  • Application Information

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Problems solved by technology

[0005] The present invention introduces cyclodextrin in order to solve the low-density boron affinity material’s low adsorption efficiency and slow shortcomings and the problem of embedding of functional monomers, and improves the adsorption capacity of the material by atom transfer radical polymerization (ATRP). boric acid density, thereby increasing the adsorption efficiency of the adsorbent

Method used

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  • Method for preparing high-density boric acid site adsorbent based on supramolecular interface assembly strategy
  • Method for preparing high-density boric acid site adsorbent based on supramolecular interface assembly strategy
  • Method for preparing high-density boric acid site adsorbent based on supramolecular interface assembly strategy

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Embodiment 1

[0041] (1) Preparation of boronic acid polymer carrier (BA-MF)

[0042] Add 0.11 mL (0.71 mmol) of 1-chloromethyl-4-vinylbenzene (4-VBA), 0.10 g (0.68 mmol) of 4-vinylphenylboronic acid and 5.0 mg of 2,2'-azobisisobutyl The mixture of nitrile AIBN was dissolved in DMF, degassed with nitrogen for 10 minutes, stirred and reacted at 80°C for 24 hours; the reaction was quenched at low temperature, the product was poured into an appropriate amount of cold ether, centrifuged, and dried at 60°C.

[0043] (2) Preparation of β-CD (A-β-CD) with double bond

[0044] 4.5 g of β-CD (β-cyclodextrin) was dissolved in 30 mL of DMF. Add 1.6 g of NaOH as a catalyst, stir magnetically at room temperature for 1 hour; control the temperature in an ice-water bath at 5° C., slowly add 4 mL of propenyl bromide dropwise while stirring, and let the reaction proceed at this temperature for 48 hours. A yellow precipitate was obtained, which was vacuum filtered and washed with a sufficient amount of ace...

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Abstract

The invention belongs to the technical field of preparation of molecular identification selective separation materials, and relates to a method for preparing a high-density boric acid site polymer adsorbent based on a supramolecular interface assembly strategy. According to the invention, the high-density boric acid site polymer adsorbent is prepared by means of initiated atom transfer radical polymerization (ATRP) and a supramolecular action; and the prepared adsorbent is used for selective adsorption and separation of albumin in a neutral solution. The high-density boric acid site polymer adsorbent prepared by the invention has higher glycoprotein selective adsorption performance, larger adsorption capacity and good acid-base response performance, and has fast adsorption and desorption properties for glycoprotein albumin.

Description

technical field [0001] The invention belongs to the technical field of molecular recognition selective separation material preparation, and relates to a method for preparing a boron-affinity adsorbent suitable for selective separation of glycoproteins, in particular to a supramolecular interface assembly strategy to prepare high-density boric acid with high sites molecular adsorbent. Background technique [0002] Glycoproteins account for more than 50% of the total proteins in the body and play an extremely important role in a variety of biological processes, such as molecular recognition, intercellular and intracellular signal transduction, and immune responses. In addition, the occurrence of many diseases is related to the glycosylation status of related proteins, thus many glycoproteins have been used as disease biomarkers and therapeutic targets. However, many glycoproteins that are important for research and clinical diagnosis exist in very low abundance in real sample...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30
CPCB01J20/22B01J20/24B01J20/261B01J20/30
Inventor 陈学平潘建明刘树成
Owner 合肥九州龙腾科技成果转化有限公司
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