The invention provides a 2, 4, 6-trichlorophenol molecular engram microsphere polymer. The invention also provides a method for preparing the 2, 4, 6-trichlorophenol molecular engram microsphere polymer. The invention also provides application of the 2, 4, 6-trichlorophenol molecular engram microsphere polymer in enriching and/or separating 2, 4, 6-trichlorophenol. The invention also provides the application of the 2, 4, 6-trichlorophenol molecular engram microsphere polymer in monitoring and/or processing the 2, 4, 6-trichlorophenol in an environmental water sample. The invention also provides a method for detecting and/or processing the 2, 4, 6-trichlorophenol in a sample through the 2, 4, 6-trichlorophenol molecular engram microsphere polymer. The polymer has simple and convenient preparation, an even grain size, a large specific surface area and pore volume, and high absorption selectivity. The polymer can be used for carrying out the experiment directly in the water environment without excessive other organic agents. The polymer is environmentally friendly and has a high absorption speed.