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External medicine for inhibiting postoperative venous thrombosis and application thereof

A technology for external use of drugs and venous thrombosis, applied in the field of medicine, can solve the problems that the specific anti-thrombotic components of Scrophulariaceae are not clearly researched, and there is no research and report, and achieve the effect of no bleeding risk, obvious antithrombotic effect, and significant effect.

Active Publication Date: 2019-04-09
山东肽莱生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Scrophulariaceae is used in many antithrombotic traditional Chinese medicines, but the specific antithrombotic components of Scrophulariaceae have not been studied clearly
Baccaratin is a chemical substance present in Scrophularia scrophulariae. Studies have shown that bacarina can resist the damage caused by hydrogen peroxide, but whether it has antithrombotic effect has not yet been studied and reported

Method used

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  • External medicine for inhibiting postoperative venous thrombosis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Inhibit postoperative venous thrombosis external gel

[0067] Xanthohumol 1g

[0068] Carbomer 940 1g

[0069] 95% ethanol 20g

[0070]Glycerin 10g

[0071] Triethanolamine 1.5g

[0072] Distilled water up to 100g

[0073] preparation:

[0074] Take the prescribed amount of carbomer 940 and add distilled water to make a solution with a mass concentration of 4%, and let it stand overnight to fully swell;

[0075] Take the prescribed amount of 95% ethanol, xanthohumol, and glycerin and mix evenly, add it to the carbomer 940 solution, mix evenly, add the prescribed amount of triethanolamine dropwise while stirring to form a gel, then add distilled water to 100g, stir well, Instantly.

Embodiment 2

[0076] Example 2 Suppression of Postoperative Venous Thrombosis External Gel

[0077] Xanthohumol 0.3g

[0078] Nucarina 0.7 g

[0079] Carbomer 940 1g

[0080] 95% ethanol 20g

[0081] Glycerin 20g

[0082] Triethanolamine 1.5g

[0083] Distilled water up to 100g

[0084] preparation:

[0085] Take the prescribed amount of carbomer 940 and add distilled water to make a solution with a mass concentration of 4%, and let it stand overnight to fully swell;

[0086] Take the prescribed amount of 95% ethanol, bacarina, xanthohumol, and glycerin, mix them evenly, add them to the carbomer 940 solution, and after mixing evenly, add the prescribed amount of triethanolamine dropwise while stirring to form a gel, and then add distilled water to 100g, stir well, that is.

Embodiment 3

[0087] Example 3 Suppression of Postoperative Venous Thrombosis External Gel

[0088] As another preferred solution, the prescription and preparation method of the gel for external use are as follows:

[0089] Xanthohumol 0.3g

[0090] Nucarina 0.5 g

[0091] Carbomer 940 1g

[0092] 95% ethanol 20g

[0093] Glycerin 15g

[0094] Triethanolamine 1.5g

[0095] Distilled water up to 100g

[0096] preparation:

[0097] Take the prescribed amount of carbomer 940 and add distilled water to make a solution with a mass concentration of 4%, and let it stand overnight to fully swell;

[0098] Take the prescribed amount of 95% ethanol, bacarina, xanthohumol, and glycerin, mix them evenly, add them to the carbomer 940 solution, and after mixing evenly, add the prescribed amount of triethanolamine dropwise while stirring to form a gel, and then add distilled water to 100g, stir well, that is.

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PUM

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Abstract

The invention belongs to the field of medicines, and particularly relates to an external medicine for inhibiting postoperative venous thrombosis and application thereof. The external medicine for inhibiting postoperative venous thrombosis is xanthohumol or a composition of xanthohumol and harpagoside. The external medicine for inhibiting postoperative venous thrombosis is preferably an external gel. The weight ratios of the xanthohumol and the harpagoside in the composition of the xanthohumol and the harpagoside are 3 parts by weight and 5-7 parts by weight, respectively. The external medicineused as the external gel includes the following components: carbomer 940, 95% ethanol, glycerin, triethanolamine and distilled water. The external medicine for inhibiting postoperative venous thrombosis has a significant inhibitory effect on thrombus formation before or after surgeries, and no increase in the risk of bleeding is observed.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to an externally applied medicament for inhibiting postoperative venous thrombosis and its application. Background technique [0002] There are specific procoagulant and anticoagulant substances in the blood system. For most people, under normal conditions, the procoagulant and anticoagulant systems in the body are in a state of dynamic balance. In the process of surgery or trauma, when bleeding occurs, the body itself will promote blood coagulation in the wound through the coagulation system to avoid excessive blood loss. This homeostatic mechanism is one of the ways the body achieves self-protection. [0003] Surgical procedures can damage blood vessels and disrupt the balance between coagulation and fibrinolytic systems, thereby inducing a hypercoagulable state and easily leading to thrombosis. Postoperative venous thrombosis occurs mainly in veins with slow blood flow. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/12A61K9/06A61P7/02
CPCA61K9/0014A61K9/06A61K31/12A61K31/7048A61K47/32A61P7/02A61K2300/00
Inventor 赵永波李萍刘晓双
Owner 山东肽莱生物制药有限公司
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