Method for conducting drug loading by adopting SC-CO2 (supercritical carbon dioxide) extraction device with GO (graphene oxide) or CNTs (carbon nano tubes) as carrier

An extraction device and carbon dioxide technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low loading, and achieve the advantages of loading, avoiding pollution or separation problems , the effect of increasing drug loading

Active Publication Date: 2019-04-09
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problem of low loading capacity of the existing physical loading method for loading drugs on the carrier, the present invention proposes a method for drug loading using a supercritical carbon dioxide extraction device using GO or CNTs as a carrier

Method used

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  • Method for conducting drug loading by adopting SC-CO2 (supercritical carbon dioxide) extraction device with GO (graphene oxide) or CNTs (carbon nano tubes) as carrier
  • Method for conducting drug loading by adopting SC-CO2 (supercritical carbon dioxide) extraction device with GO (graphene oxide) or CNTs (carbon nano tubes) as carrier
  • Method for conducting drug loading by adopting SC-CO2 (supercritical carbon dioxide) extraction device with GO (graphene oxide) or CNTs (carbon nano tubes) as carrier

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Experimental program
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specific Embodiment approach 1

[0037] Specific implementation mode 1: In this implementation mode, a supercritical carbon dioxide extraction device is used to carry out drug loading with GO or CNTs as a carrier according to the following steps:

[0038] Step 1: weighing the carrier, and placing the weighed carrier in the extraction tank of the supercritical extraction device;

[0039] Step 2: Weighing the drug, dissolving the weighed drug in absolute ethanol to obtain a mixed solution, and transferring the mixed solution to the entrainer tank of the supercritical extraction device;

[0040] Step 3: Send the mixed liquid in the entrainer tank to the extraction tank containing the carrier with a delivery pump, adjust the pressure and temperature of the extraction tank, carry out drug loading to obtain a drug-loaded product, and dry the obtained drug-loaded product at room temperature for 22 ~26h, it is completed.

[0041] This embodiment has the following beneficial effects:

[0042] 1. In this embodiment, ...

specific Embodiment approach 2

[0046] Embodiment 2: This embodiment differs from Embodiment 1 in that the carrier in step 2 is GO or CNTs. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0047] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the mass ratio of the drug to the carrier is (1-4):1. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention provides a method for conducting drug loading by adopting an SC-CO2 (supercritical carbon dioxide) extraction device with GO (graphene oxide) or CNTs (carbon nano tubes) as a carrier, and relates to a method for conducting the drug loading with GO or CNTs as the carrier. The method comprises steps as follows: the weighed carrier is put in an extraction tank of a supercritical extraction device, a weighed drug is dissolved in absolute ethyl alcohol, a mixed solution is obtained and transferred into an entrainer tank of the supercritical extraction device, the mixed solution in theentrainer tank is conveyed by a delivery pump to the extraction tank containing the carrier, pressure and temperature of the extraction tank are adjusted, the drug loading is performed under the conditions of certain raw material ratio and loading time, and a drug-loaded product is obtained and dried for 22-26 h at the room temperature. Supercritical CO2 is utilized for drug loading, the problemof pollution or separation of a solvent used for drug loading with a conventional method is solved, and the drug loading capacity is increased. The method is suitable for the drug loading with GO or CNTs as the carrier.

Description

technical field [0001] The invention relates to a method for drug loading by using a supercritical carbon dioxide extraction device and using GO or CNTs as a carrier. Background technique [0002] Graphene is currently the thinnest and strongest new polymer material in nature. It has excellent mechanical properties, good biocompatibility, and low toxicity. However, due to the strong van der Waals force, graphene is hydrophobic and easy to agglomerate, which limits its wide application. The emergence of graphene oxide just solved the above problems. Graphene oxide (GO) is a derivative of graphene with high specific surface energy, good hydrophilicity and mechanical properties. It has good dispersion stability in organic solvents. There are hydroxyl groups, epoxy groups, carbonyl groups, carboxyl groups, etc. between graphene oxide sheets. The surface area and the abundant functional groups on the surface endow it with excellent composite performance. Due to the similarity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/52A61K47/04A61K31/616A61K31/337A61K31/704
CPCA61K47/02A61K47/52A61K31/337A61K31/616A61K31/704
Inventor 张杰祝芳芳张宇胡明崔虹云宋立梅
Owner JIAMUSI UNIVERSITY
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