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Method for manufacturing bone tissue engineering scaffold by adopting macrostructure and microstructure imitating trabecular bone

A technology of bone tissue engineering and production method, which is applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of lack of bone augmentation efficiency and effect, slow bone formation speed, and inability to prevent infection well, to achieve Improve the efficiency and effect of osteogenesis and prevent infection

Pending Publication Date: 2019-04-12
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Although the existing osteogenic materials can promote the growth of bone tissue, the main problems are: first, it is not conducive to the macroscopic and microscopic structure of osteogenesis, and the osteogenesis speed is slow; second, it cannot well solve the problem of preventing infection; Lacking in efficiency and effectiveness for bone augmentation

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  • Method for manufacturing bone tissue engineering scaffold by adopting macrostructure and microstructure imitating trabecular bone
  • Method for manufacturing bone tissue engineering scaffold by adopting macrostructure and microstructure imitating trabecular bone

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Experimental program
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Effect test

Embodiment 1

[0020] 1) The macroscopic structure of the engineering scaffold is divided into two layers, the outer layer is used to contact with soft tissue, the thickness of the outer layer is 0.05-0.1mm, the surface is smooth, and can shield the growth of soft tissue; the inner layer is for rapid bone formation of human body Early trabecular bone structure with a cross-sectional diameter of about 0.5-2mm, designed with CAD software and generated with 3D printing software to print files;

[0021] 2) Degradable polycaprolactone material is used as the structural support material, with 50 parts by mass;

[0022] 3) Using hydroxyapatite that can induce osteogenesis as a functional filler, the mass part is 40 parts;

[0023] 4) Using 0.2-100 micron diameter soluble sodium chloride and antibiotic particles as the microstructure forming material, the parts by mass are 10 parts;

[0024] 5) Mix the various materials in steps 2)-4) evenly, and use a granulator to make granules;

[0025] 6) Acco...

Embodiment 2

[0029] 1) The macroscopic structure of the engineering scaffold is divided into two layers, the outer layer is used to contact with soft tissue, the thickness of the outer layer is 0.05-0.1mm, the surface is smooth, and can shield the growth of soft tissue; the inner layer is for rapid bone formation of human body Early trabecular bone structure with a cross-sectional diameter of about 0.5-2mm, designed with CAD software and generated with 3D printing software to print files;

[0030] 2) Using degradable polycaprolactone material as the structural support material, the parts by mass are 60 parts;

[0031] 3) Using hydroxyapatite capable of inducing osteogenesis as a functional filler, with 20 parts by mass;

[0032] 4) Using sodium chloride and antibiotic particles with a diameter of 0.2-100 microns that can be dissolved at room temperature as the microstructure forming material, the mass ratio is 20 parts;

[0033] 5) Mix the various materials in steps 2)-4) evenly, and use ...

Embodiment 3

[0038] 1) The macroscopic structure of the engineering scaffold is divided into two layers, the outer layer is used to contact with soft tissue, the thickness of the outer layer is 0.05-0.1mm, the surface is smooth, and can shield the growth of soft tissue; the inner layer is for rapid bone formation of human body Early trabecular bone structure with a cross-sectional diameter of about 0.5-2mm, designed with CAD software and generated with 3D printing software to print files;

[0039] 2) Degradable polycaprolactone material is used as the structural support material, with 70 parts by mass;

[0040] 3) Using hydroxyapatite that can induce osteogenesis as a functional filler, the mass part is 25 parts;

[0041] 4) Using 0.2-100 micron diameter soluble sodium chloride and antibiotic particles as the microstructure forming material, the parts by mass are 5 parts;

[0042] 5) Mix the various materials in steps 2)-4) evenly, and use a granulator to make granules;

[0043] 6) Accor...

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Abstract

The invention relates to a method for manufacturing a bone tissue engineering scaffold by adopting a macrostructure and microstructure imitating trabecular bone, comprising the following steps: 1) themacrostructure of a engineering scaffold is divided into two layers, a CAD software is used for designing and a 3D printing software is used to generate a printing file; 2) a polycaprolactone material is adopted as a structural support material; 3) hydroxyapatite is adopted as a functional filler; 4) sodium chloride and antibiotic particles are adopted as microstructure forming materials; 5) thematerials of the steps 2) to 4) are uniformly mixed and made into granules; 6) a fused deposition modeling 3D printer is used for printing modeling; 7) a printed body is ultrasonically oscillated in normal-temperature distilled water for 10 to 30 minutes to fully dissolve sodium chloride particles, so that microscopic pores are formed in the printed body; and 8) after disinfection, the printed body can be used as a bone increment product. The bone increment product of the invention can be used for various types of bone incremental surgeries, a degradable material is adopted, and the bone increment product can prevent infection, and improve bone formation efficiency and effect.

Description

technical field [0001] The invention relates to a manufacturing method of an oral medical product, in particular to a manufacturing method of a bone tissue engineering bracket imitating the macro-microstructure of bone trabeculae. Background technique [0002] Although the existing osteogenic materials can promote the growth of bone tissue, the main problems are: first, it is not conducive to the macroscopic and microscopic structure of osteogenesis, and the osteogenesis speed is slow; second, it cannot well solve the problem of preventing infection; It is lacking in efficiency and effectiveness for bone augmentation. Contents of the invention [0003] The purpose of the present invention is to provide a bone tissue engineering scaffold manufacturing method that imitates the macro-microstructure of bone trabeculae, which can be used in various types of bone augmentation surgery. Infection, improve the efficiency and effect of osteogenesis. [0004] In order to achieve th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/54A61L27/56
CPCA61L27/12A61L27/18A61L27/54A61L27/56A61L2300/406A61L2430/02C08L67/04
Inventor 孙玉春周永胜刘云松王勇李榕陈虎陈科龙
Owner PEKING UNIV SCHOOL OF STOMATOLOGY