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Construction method of semen oroxyli formula granule UPLC specific chromatogram and application thereof

A technology of formula granules and characteristic maps, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems that there is no effective method for controlling the quality of wood butterfly formula granules, and achieve the effect of an effective and rapid evaluation method

Active Publication Date: 2019-04-19
GUANGDONG YIFANG PHARMA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Wood Butterfly formula granules are made of single Chinese herbal medicine pieces through water extraction, concentration, drying, and granulation. At present, there is no effective method to control the quality of Wood Butterfly formula granules.

Method used

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  • Construction method of semen oroxyli formula granule UPLC specific chromatogram and application thereof
  • Construction method of semen oroxyli formula granule UPLC specific chromatogram and application thereof
  • Construction method of semen oroxyli formula granule UPLC specific chromatogram and application thereof

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Embodiment Construction

[0031] The present invention will be further described below through specific embodiments. The following examples are specific embodiments of the present invention, but the embodiments of the present invention are not limited by the following examples.

[0032] 1. Instruments and reagents

[0033] 1.1 Instrument

[0034] Waters liquid mass spectrometer (liquid part ACQUITY UPLC H-Class, mass spectrometry part Waters Xevo TQDMS); millionth balance (METTLER TOLEDO, XP26), one millionth balance (METTLER TOLEDO, ME204E), Agilent SB C 18 Chromatographic column (2.1×100mm, 1.8μm), electric heating constant temperature water bath (Shanghai Yiheng Technology Co., Ltd., HWS-28), numerical control ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd., KQ500DE), ultrapure water system (Merck Incorporated, Milli-Q-Direct).

[0035] 1.2 Reference substances and reagents

[0036] Acetonitrile (Merck, Germany, chromatographically pure); ethanol (Xilong Science Co., Ltd., analytical...

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Abstract

The invention discloses a construction method of a semen oroxyli formula granule UPLC specific chromatogram and application thereof. The construction method includes the steps of preparing a referencesubstance solution, preparing a test substance solution, adopting ultra-performance liquid chromatography to carry out measurement, building the specific chromatogram, conducting similarity evaluation and the like. By adopting the construction method, the UPLC specific chromatogram of semen oroxyli formula granules is built, and through a liquid chromatography and mass spectrometry combination technology, six common components of the semen oroxyli formula granules are qualitatively and quantitatively analyzed rapidly. The construction method is a comprehensive, systematic and effective rapidevaluation method for quality evaluation and control of the semen oroxyli formula granules.

Description

technical field [0001] The invention belongs to the technical field of drug analysis and drug quality control, and in particular relates to a construction method and application of a characteristic map of wood butterfly formula granules. Background technique [0002] Wood butterfly (Oroxyli semen) is the dry mature seed of Oroxylumindicum (L) Vent., also known as Melaleuca paper, jade butterfly, etc. It was first recorded in "Southern Yunnan Materia Medica", and has hundreds of years of history Medicinal history. The theory of traditional Chinese medicine believes that the wood butterfly is bitter, sweet and cool in nature and taste, enters the lung, liver and stomach meridian, has the effect of clearing the lung and pharynx, soothing the liver and harmonizing the stomach, and is used for cough due to lung heat, sore throat, hoarseness, pain in the liver and stomach, It is often used for upper respiratory tract infection, acute bronchitis, chronic pharyngitis, late pneumoni...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李国卫何民友曹斯琼王利伟吴淑珍索彩仙黄敏烨吴文平陈向东
Owner GUANGDONG YIFANG PHARMA
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