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Method for testing validity period of wet wipe product

A determination method and technology of validity period, applied in the field of the validity period of wet wipes products, can solve the problems of insufficient validity period arguments, insufficient basis, non-compliance, etc., and achieve the effect of shortening the test period and ensuring the accuracy

Active Publication Date: 2019-04-30
YANGZHOU PERFECT DAILY CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, after our previous tests on the stability of wet wipes, the method in the national standard only simply stipulates the temperature of the accelerated test, and this method does not conform to the Arrhenius equation in the chemical field about accelerated aging: k=Ae -Eα / RT
Therefore, the basis for the stability test method of wet wipes is insufficient, resulting in insufficient evidence for the validity period of wet wipe product stability calculations, and the detection standards for drug wipes in wet wipe products are relatively high. The method in the national standard is adopted. The stability and expiry date indicated cannot accurately reflect the essential performance of wet wipe products

Method used

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  • Method for testing validity period of wet wipe product
  • Method for testing validity period of wet wipe product
  • Method for testing validity period of wet wipe product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 prepares test solution

[0045] Sterilize the front end of the scissors in an infrared heating sterilizer for injection needles for at least 5 seconds, then cool for at least 5 seconds, cut open the sample packaging bag, cut 20g of sample from the upper part of the sample into a 180ml jar containing solution D, and mark it briefly The digital batch number, sampling date. Place the jar on a shaker and oscillate at a speed of 190-220 rpm for at least 10 minutes to obtain a test solution with a mass-volume ratio of 1:10.

Embodiment 2

[0046] The mensuration of embodiment 2 total amount of aerobic bacteria and mold yeast

[0047] Install the membrane filter on the device, take out 10ml of 1:10 test solution, after filtering, take 100ml of solution D to rinse, after filtering, sterilize the tip of the tweezers in an infrared heating sterilizer for injection needles for at least 5 seconds, take out After cooling for at least 5 seconds, stick the primary membrane on the pre-marked TSAWLP plate with tweezers, and place the TSAWLP plate in a 30-35°C incubator for 3-5 days. Stick another membrane on the pre-labeled SDAWLP plate, and place the SDAWLP plate in a 20-25°C incubator for 5-7 days.

[0048] The preparation method of the solution D is as follows: dissolve 1g of peptone in 1000ml of purified water, then add 1ml of Tween-80, after the dissolution is complete, adjust the pH to 7.1±0.2, and sterilize at 121°C for 20 minutes, namely have to.

[0049] The detection results are as described in Table 1, wherein...

Embodiment 3

[0055] The detection of embodiment 3 Staphylococcus aureus

[0056] Take 10ml of 1:10 test solution and filter it, rinse and filter with 100ml solution D, put the filter membrane into 100ml soybean-casein digest broth (TSB), and incubate at 30-35℃ for 18-24 hours At 20 o'clock, the initial enrichment solution A was obtained. Use an inoculation loop to pick a ring from the initial enrichment solution A and spread it evenly on Mannitol Sodium Chloride Agar (MSA), and incubate it upside down at 30-35°C for 18-72 hours; if there are yellow colonies on the MSA plate or the periphery is yellow If there is no growth of white colonies that match the above-mentioned morphological characteristics or suspected growth on the plate, or there are consistent or suspected growth of colonies but The result of Gram staining was negative, and it was judged that Staphylococcus aureus was not detected in the test product. The test results are shown in Table 2.

[0057] Table 2 Detection of Stap...

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Abstract

The invention discloses a method for testing the validity period of a wet wipe product. The method comprises the steps: placing a test sample under conditions of the temperature of 38 DEG C-42 DEG C and the relative humidity of 70%-80%, placing for 12 weeks, at the same time, placing the test sample under conditions of the temperature of 52 DEG C-56 DEG C and the relative humidity of 70%-80%, placing for 12 weeks, and measuring the weight change, the wet wipe appearance, the extrusion fluid appearance, odor, pH value, label inner side color, packaging integrity, packaging airtightness and microbial limit timingly. Compared with the prior art, the method integrates the requirements of wet wipe national standards and the drug stability test guide of the Chinese Pharmacopoeia, optimizes the wet wipe product, has more sufficient arguments than that of calculation of the validity period of the wet wipe national standards, and has the test period shorter than that of the Chinese Pharmacopoeia; moreover, more extreme conditions simulating the transportation and use of actual products are added to detect the key quality parameters of the wet wipe product, and the accuracy of the validity period judgment is ensured.

Description

technical field [0001] The invention belongs to the field of disposable hygiene products, and in particular relates to a method for measuring the validity period of a wet tissue product. Background technique [0002] The purpose of the stability test is to investigate the change of the product over time under the influence of temperature, humidity and light conditions, to provide a scientific basis for the production, packaging, storage and transportation of the product, and to establish the validity period of the product through experiments. At present, the stability test method of wet wipe products is mainly based on the test specified in the national standard. The conclusion of the wet wipe national standard GB15979-2002 is: Accelerated test: put the original packaging sample in a 54-57 ℃ incubator for 14 days Product stability If the test result is passed, it can be inferred that it can be kept at room temperature for at least 1 year; if the product stability test result...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/14C12Q1/10C12Q1/04C12R1/445C12R1/19C12R1/385C12R1/42C12R1/645
CPCC12Q1/04C12Q1/10C12Q1/14G01N2333/245G01N2333/255G01N2333/21G01N2333/39G01N2333/37
Inventor 俞晨波
Owner YANGZHOU PERFECT DAILY CHEM