Vacuum interaction system applicable to laser desorption/ionization time-of-flight mass spectrometer

Abstract

The invention discloses a vacuum interaction system applicable to a laser desorption / ionization time-of-flight mass spectrometer. The vacuum interaction system comprises a vacuum chamber provided witha vacuumizing device on the outer side, wherein a sealing cover plate of the vacuum chamber is provided with a pressure detection unit, and a sample entrance / exit of the sealing cover plate is provided with a sample incoming and outgoing cabin door in a sealed manner; and the vacuum chamber is internally provided with a sample target holder driven by means of a power unit, the power unit comprises a horizontal driving mechanism and a lifting mechanism, the horizontal driving mechanism drives the sample target holder to move horizontally, the lifting mechanism drives the sample target holder to move vertically, the lifting mechanism comprises a fixed base connected onto the bottom wall of the vacuum chamber by means of limiting screws, a jacking boss corresponding to the sample entrance / exit vertically is connected above the fixed base by means of a scissors-shaped lifting frame driven by a first power source, and reset springs are arranged in a compression gap between the fixed base and the bottom wall of the vacuum chamber at intervals. The vacuum interaction system has the advantages that the structure is simple, the running stability of the lifting mechanism is good, the replacement of samples is ensured to be conducted smoothly, and the machine failure rate is reduced.

Description

technical field [0001] The invention relates to a matrix-assisted laser analysis ionization time-of-flight mass spectrometer, in particular to a vacuum interactive system suitable for a laser analysis ionization time-of-flight mass spectrometer. Background technique [0002] MALDI-TOF MS (matrix-assisted laser desorption ionization time-of-flight mass spectrometer) mass spectrometry system is a new type of soft ionization biological mass spectrometer. The instrument is mainly composed of two parts: matrix-assisted laser desorption ionization ion source (MALDI) and time-of-flight mass analyzer (TOF). The principle of MALDI is to irradiate the co-crystallized film formed by the sample and the matrix with laser light. The matrix absorbs energy from the laser and transmits it to the biomolecules; Determination of macromolecules. The principle of TOF is that ions accelerate through the flight tube under the action of an electric field, and are detected according to the flight t...

AI Technical Summary

Problems solved by technology

However, the lifting module of the existing power mechanism is a multi-stage connecting rod transmission mechanism, which has a complex structure and takes up a lot of space. During work, jamming and stalling often occur, and the failure rate of the machine is high; and once a machine failure occurs, it needs to be shut down for debugging and shutdown. It takes a long time to reduce the efficiency of sample identification

Images