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Self-driven paper-based micro-fluidic chip composed based on strip-shaped gradient array and wedge-shaped flow channel

A microfluidic chip and wedge flow technology, applied to laboratory containers, laboratory utensils, chemical instruments and methods, etc., can solve the problems of insufficient precision, increasing gap between hydrophilicity and hydrophobicity, etc., and achieve simple operation and simple equipment , low-cost production effect

Inactive Publication Date: 2019-05-17
ZHEJIANG UNIV OF TECH
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  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to address the deficiencies of the prior art, to propose a novel gradient surface, and to construct a wedge-shaped flow channel with a precisely designed strip gradient array, which can increase the hydrophilic-hydrophobic gap inside and outside the flow channel and prevent droplets from Pattern structure design and preparation method of paper-based microfluidic chip that diffuses out of the flow channel and can solve the problem of insufficient precision

Method used

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  • Self-driven paper-based micro-fluidic chip composed based on strip-shaped gradient array and wedge-shaped flow channel
  • Self-driven paper-based micro-fluidic chip composed based on strip-shaped gradient array and wedge-shaped flow channel
  • Self-driven paper-based micro-fluidic chip composed based on strip-shaped gradient array and wedge-shaped flow channel

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Embodiment 1

[0031] A method for preparing a self-driven paper-based microfluidic chip based on a strip-shaped gradient array and a wedge-shaped flow channel, comprising the following steps:

[0032] 1) Preparation of superhydrophobic titanium dioxide nanoparticle suspension: disperse 0.1 g of titanium dioxide powder with a particle size of about 25 nm in 10 mL of ethanol, and ultrasonically disperse it for 1 h to make it uniform; Oxysilane) was added to the dispersion, ultrasonicated for 10 minutes, and reacted at room temperature for 12 hours to obtain a silanized titanium dioxide nanoparticle suspension.

[0033] 2) Prepare the paper substrate of the superhydrophobic microfluidic chip with micro-nano composite structure: cut the filter paper into small pieces of 1.5cm3cm, then soak the filter paper in the silane-treated dispersion, take it out after 5min, and dry it naturally at room temperature; repeat Such operations are performed three times to obtain a superhydrophobic filter paper ...

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Abstract

The invention discloses a structural design and preparation method for a self-driven paper-based micro-fluidic chip composed based on a strip-shaped gradient array and a wedge-shaped flow channel. Theself-driven micro-fluidic chip is composed of two parts, namely the wedge-shaped flow channel and the strip-shaped gradient array, wherein the wedge-shaped flow channel provided the Laplace pressuregradient, the strip-shaped gradient array is arranged in the wedge-shaped flow channel, wetting gradient force is provided by changing the hydrophilic and hydrophobic area fraction. According to the structural design and preparation method for the self-driven paper-based micro-fluidic chip provided by the invention, compared with other gradient wetting surfaces, a wetting gradient surface formed by the strip-shaped gradient array and the wedge-shaped flow channel can provide larger wetting driving force, and the self-driving of liquid drops is easier to realize; by means of the design method,auxiliary equipment such as an external force driving system can be removed in a plane micro-fluidic system, and miniaturization and portability of the micro-fluidic system are easier to realize, andin addition, required equipment is simple, the operation is simple and convenient, and as for the preparation environment, the implementation can be carried out in air.

Description

technical field [0001] A self-propelled paper-based microfluidic chip based on strip gradient arrays and wedge-shaped flow channels. Background technique [0002] People's research on gradient wetting surfaces originated in 1855, and Thmson explained the phenomenon of "tears of wine". He believes that due to the volatilization of alcohol, a gradient concentration film with gradually decreasing alcohol concentration is formed on the inner wall of the wine glass, thus forming a surface tension gradient on the surface of the side wall, which induces the upward movement of the droplet. The directional wettability of droplets on the gradient surface of arrays has good applications in many fields, and paper-based microfluidics is one of the important components. The huge potential shown by the paper-based microfluidic chip makes it destined to become a deeply industrialized science and technology. First of all, this judgment is of course due to the irreversible demand for global...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 吴化平刘其辉朱凯丁浩彭翔张征
Owner ZHEJIANG UNIV OF TECH
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