Diflunisal dry suspension and preparation method thereof

A technology of diflunisal and dry suspension, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as quality changes and secondary pollution

Inactive Publication Date: 2019-05-21
HENAN TIANSHENG TAIFENG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of diflunisal dry suspension with high bioavailability, good stability, convenient administration, accurate dosage and preparation method thereof. Type powder packing machine overcomes the defects that the single bag package is easy to change in quality after opening, and repeated sampling is easy to cause secondary pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Diflunisal 150g

[0016] Sodium carboxymethyl starch 100g

[0017] Hydroxypropyl Methyl Cellulose 200g

[0018] Sucrose 8g

[0019] Citron tincture 2g

[0020] Micronized silica gel 50g

[0021] Mannitol 1000g

[0022] Make 1000 bags

[0023] Preparation

[0024] Weigh diflunisal, sodium carboxymethyl starch, hydroxypropyl methylcellulose, sucrose, tincture of citron, micropowder silica gel, and mannitol according to the prescription ratio, mix well, pulverize, pass through an 80-mesh sieve, and mix well , make 0.05g / bag of diflunisal dry suspension by sub-packaging with metering powder packing machine.

Embodiment 2

[0026] Diflunisal 80g

[0027] Sodium carboxymethyl starch 120g

[0028] Hydroxypropyl Methyl Cellulose 150g

[0029] Sucrose 8g

[0030] Citron tincture 2g

[0031] Micronized silica gel 50g

[0032] Mannitol 1000g

[0033] Make 1000 bags

[0034] Preparation

[0035] Weigh diflunisal, sodium carboxymethyl starch, hydroxypropyl methylcellulose, sucrose, tincture of citron, micropowder silica gel, and mannitol according to the prescription ratio, mix well, pulverize, pass through an 80-mesh sieve, and mix well , make 0.05g / bag of diflunisal dry suspension by sub-packaging with metering powder packing machine.

Embodiment 3

[0037] Diflunisal 100

[0038] Sodium carboxymethyl starch 140g

[0039] Hydroxypropyl Methyl Cellulose 180g

[0040] Sucrose 8g

[0041] Citron tincture 2g

[0042] Micronized silica gel 50g

[0043] Mannitol 1000g

[0044] Make 1000 bags

[0045] Preparation

[0046] Weigh diflunisal, sodium carboxymethyl starch, hydroxypropyl methylcellulose, sucrose, tincture of citron, micropowder silica gel, and mannitol according to the prescription ratio, mix well, pulverize, pass through an 80-mesh sieve, and mix well , make 0.05g / bag of diflunisal dry suspension by sub-packaging with metering powder packing machine.

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PUM

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Abstract

The invention discloses a diflunisal dry suspension and a preparation method thereof. The dry suspension is obtained by the following steps: 20 to 200 parts by weight of diflunisal, 200 to 1200 partsby weight of a filler, 100 to 400 parts by weight of a binder, 10 to 200 parts by weight of a flow aid, 5 to 10 parts by weight of a sweetener, and 1 to 3 parts by weight of aroma are respectively weighed, the materials are crushed, passed through a 80 mesh sieve, and uniformly mixed, and a metered powder dispenser is used to prepare the diflunisal dry suspension. Compared with the existing preparation technology, the diflunisal dry suspension prepared by the invention has the advantages of convenient administration, accurate dosage, and convenient carrying.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a diflunisal dry suspension and a preparation method thereof. Background technique [0002] Diflunisal, a non-steroidal anti-inflammatory analgesic, is the most promising alternative to aspirin. It is clinically used for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, sprains, strains and pain relief. Studies have shown that diflunisal and ibuprofen are equally effective in the treatment of rheumatoid arthritis and degenerative arthritis. During the observation, it was also found that diflunisal was significantly better than ibuprofen in improving the grip strength of patients with rheumatoid arthritis and relieving joint pain and tenderness in rheumatoid arthritis and degenerative arthritis. At the same time, diflunisal can reduce and relieve rheumatoid factor titer and morning stiffness in patients with rheumatoid arthritis. The analgesi...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/603A61P29/00A61P19/02A61P19/08A61P21/00
Inventor 沙薇冯林洁
Owner HENAN TIANSHENG TAIFENG PHARM TECH CO LTD
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