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A kind of preparation method of chitosan quaternary ammonium salt-fatty acid vesicle

A chitosan quaternary ammonium salt, fatty acid technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of limited application, low stability, narrow pH range, etc., to ensure effective supply and enhance system stability. , good stability

Active Publication Date: 2020-12-25
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pH range of fatty acid vesicle formation is narrow, and the environment is alkaline, and the stability is not high, which limits its application.

Method used

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  • A kind of preparation method of chitosan quaternary ammonium salt-fatty acid vesicle
  • A kind of preparation method of chitosan quaternary ammonium salt-fatty acid vesicle
  • A kind of preparation method of chitosan quaternary ammonium salt-fatty acid vesicle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1) Preparation of chitosan quaternary ammonium salt solution: Dissolve chitosan quaternary ammonium salt (2-hydroxypropyltrimethylammonium chloride chitosan) in water, stir at room temperature, and prepare a sugar unit of 20mmol / The chitosan quaternary ammonium salt solution of L is standby;

[0029] 2) Preparation of sodium oleate solution: add an appropriate amount of oleic acid into 30mmol / L NaOH solution, stir at room temperature for 30min, and prepare 20mmol / L sodium oleate solution for later use;

[0030] 3) Preparation of composite vesicles: Dilute the chitosan quaternary ammonium salt solution with a sugar unit concentration of 20mmol / L to 10mmol / L with water, then dilute the 20mmol / L sodium oleate solution to 5mmol / L, at 20°C , adding an equal volume of sodium oleate solution dropwise to the chitosan quaternary ammonium salt solution, and stirring slowly at 60 rpm to obtain a composite vesicle solution;

[0031] 4) pH adjustment of the vesicle solution: adjus...

Embodiment 2

[0033] 1) Preparation of chitosan quaternary ammonium salt solution: Dissolve chitosan quaternary ammonium salt (2-hydroxypropyltrimethylammonium chloride chitosan) in water, stir at room temperature, and prepare a sugar unit of 20mmol / The chitosan quaternary ammonium salt solution of L is standby;

[0034] 2) Preparation of sodium oleate solution: add an appropriate amount of oleic acid into 30mmol / L NaOH solution, stir at room temperature for 30min, and prepare 20mmol / L sodium oleate solution for later use;

[0035] 3) Preparation of composite vesicles: dilute 20mmol / L sodium oleate solution to 16mmol / L, do not dilute chitosan quaternary ammonium salt solution, add an equal volume of sodium oleate solution dropwise to chitosan at 40°C In the sugar quaternary ammonium salt solution, stir slowly at 80rpm to prepare the composite vesicle solution;

[0036] 4) pH adjustment of the vesicle solution: adjust the pH of the vesicle solution with 0.5mol / L hydrochloric acid solution,...

Embodiment 3

[0038] In order to investigate the stability of the vesicles, add 0.5mol / L hydrochloric acid or sodium hydroxide to the vesicle fluid prepared in Example 1 and Example 2 and the comparative sample sodium oleate (10mmol / L, pH=9) , adjust the pH of the solution, and visually observe the appearance of the solution, the results are shown in Table 1.

[0039] Table 1. Appearance of sample solution at different pH

[0040]

[0041] It can be seen from Table 1 that for the sodium oleate system, only when the pH is 8 to 10, the solution has the unique blue color of the vesicles; while for the sodium oleate-chitosan quaternary ammonium salt system, when the pH is 1 At ~5 and 8~13, the solutions all showed the blue color characteristic of vesicles.

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Abstract

The invention discloses a preparation method of chitosan quaternary ammonium salt-fatty acid vesicles, comprising the following steps: 1) preparation of chitosan quaternary ammonium salt solution: dissolving chitosan quaternary ammonium salt in water and stirring at room temperature , prepared into chitosan quaternary ammonium salt solution; 2) preparation of sodium oleate solution: oleic acid was added to NaOH aqueous solution, stirred at room temperature to obtain sodium oleate solution, for subsequent use; 3) preparation of composite vesicles: Add the sodium oleate solution prepared in step 2) dropwise into the chitosan quaternary ammonium salt solution prepared in step 1), and stir slowly at 5-45° C. to prepare a composite vesicle solution. The invention provides stable oleic acid / chitosan quaternary ammonium salt vesicles prepared in a wider pH range (1-5 and 8-13), realizing that the same system can be used in both acid and alkaline environments Vesicles are formed, and oleic acid vesicles are only formed in the pH range of 8.2-10, therefore, the present invention can effectively expand the application range of the composite vesicles.

Description

technical field [0001] The invention relates to a preparation method of chitosan quaternary ammonium salt-fatty acid vesicles, belonging to the technical field of composite vesicles. Background technique [0002] Chitosan is a natural macromolecular amino polysaccharide that deacetylates chitin after being treated with concentrated alkali solution. Chitosan has broad application prospects in many fields due to its unique biocompatibility, biodegradability, antibacterial properties, non-toxicity, biological activity and its unique physical and chemical properties. Chitosan quaternary ammonium salt is a derivative formed by introducing quaternary ammonium groups into the amino groups of chitosan molecules. [0003] Vesicles have attracted extensive research interest due to their biomembrane-like structure. They not only have diverse applications in the fields of food, medicine, and cosmetics, but are also important research tools for the origin of life and primitive cells. T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08K5/09C08L5/08B01J13/02
Inventor 杨继生郭磊明郭向男
Owner YANGZHOU UNIV
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