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Water-soluble licorice flavonoid composition and preparation method and application thereof

A technology of licorice flavonoids and compositions, applied in the field of water-soluble licorice flavonoids compositions and preparation thereof, can solve the problems of inability to apply, difficult operation techniques, time-consuming and high energy consumption, and achieves overcoming technical difficulties and strong operability. , the effect of easy operation

Active Publication Date: 2019-05-31
广州玮弘祺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also technologies such as patent CN102274145A that use cyclodextrin to coat licorice flavonoids to improve their water solubility, but the treatment process consumes a lot of time and energy, and the operation technology is difficult, and because of the physical properties of cyclodextrin itself, it is actually used in transparent water. Agent products will appear translucent or opaque, and still cannot be applied to transparent water-based cosmetic formulations

Method used

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  • Water-soluble licorice flavonoid composition and preparation method and application thereof
  • Water-soluble licorice flavonoid composition and preparation method and application thereof
  • Water-soluble licorice flavonoid composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4 and comparative example 1～5

[0028] The weight percentage composition of the licorice flavone composition of Examples 1~4 and Comparative Examples 1~5 is as shown in Table 1, and the preparation method of the licorice flavone composition of Embodiment 1~4 and Comparative Examples 1~5 is:

[0029] (1) Mix and stir licorice flavonoids with solvent and co-solvent and raise the temperature to 55-60° C., and keep stirring for 30 minutes.

[0030] (2) Add a solubilizing agent, and continue to heat and stir for 30 minutes.

[0031] (3) Stir and cool down to 40-45°C, add preservative, continue stirring and cool down to 30-35°C, and then discharge.

[0032] Table 1

[0033]

[0034]

Embodiment 5

[0036] The licorice flavonoid compositions prepared in Examples 1-4 and Comparative Examples 1-5 were tested for water solubility and stability.

[0037] (1) Water solubility experiment

[0038] Using the licorice flavonoid compositions of Examples 1-4 and Comparative Examples 1-5 above to prepare aqueous solutions with a weight percentage of 0.05%, 0.1%, 0.15%, 0.2%, and 0.25%, observe the appearance transparency and whether there is precipitation. The test results are shown in Table 2:

[0039] Table 2

[0040]

[0041] As can be seen from Table 2, the licorice flavonoids composition of the present invention is prepared with 0.05%, 0.1%, 0.15%, 0.2%, 0.25% aqueous solution, its appearance is transparent without precipitation, and its water solubility is high, which solves the problem of prior art due to processing The problem of poor dissolution will lead to precipitation during storage, which will affect the appearance, efficacy, skin feel and stability of the product,...

Embodiment 6

[0049] Add the licorice flavonoid compositions prepared in Examples 1-4 of the present invention and Comparative Examples 1-5 to the formula of moisturizing cream and moisturizing water at 0.25% by weight. The specific formulas of moisturizing cream and moisturizing water are shown in Table 4 by weight percentage As shown, and observe the appearance of the finished product, carry out stability tests such as cold, heat, and cold and hot cycles on the finished product, and the test results are shown in Table 5, Table 6, and Table 7:

[0050] Table 4

[0051]

[0052]

[0053] table 5

[0054]

[0055] The stability test result of table 6 moisturizing cream

[0056]

[0057]

[0058] Table 7

[0059]

[0060]It can be seen from Table 5 to Table 7 that the licorice flavonoid compositions prepared in Examples 1 to 4 of the present invention can be used in skin care products such as moisturizing cream and moisturizing water, and various formulations of cosmetic f...

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Abstract

The invention discloses a water-soluble licorice flavonoid composition. The composition is prepared from, by weight, 5-20% of licorice flavonoid, 40-60% of a cosolvent, 8-15% of a solubilizer, 0.1-1%of a preservative and the balance solvent. The composition has a synergistic effect on the water solubility of licorice flavonoid by matching the licorice flavonoid, the solvent, the cosolvent and thesolubilizer according to the specific ratio. The composition can be used in cosmetic formula systems of various dosage forms without precipitation, especially in transparent cosmetic systems, and thetransparent appearance can still be maintained; the defects of large difficulty, long time consumed for operation and high energy consumption of technologies for preparing water-soluble licorice flavonoid in the prior art are overcome.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a water-soluble licorice flavonoid composition and a preparation method and application thereof. Background technique [0002] With the rapid development of today's society, people's desire for beauty has never stopped, and daily skin care is essential, which requires the blessing of various skin care cosmetics. The current trend of skin care products is natural, safe and non-toxic side effects. [0003] Licorice flavonoids, extracted from licorice through multiple processes, come from natural sources, have whitening, anti-inflammatory, and antioxidant effects, and are known as "whitening gold" because of their ability to inhibit the activity of tyrosinase and thereby inhibit the production of melanin . Although licorice flavonoids have a variety of skin care and beauty effects, they are not widely used. The reason is closely related to its own structural properties. Licoric...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/49A61K8/86A61K8/92A61K8/9789A61Q19/00
Inventor 林宇祺范侨森邓宇航
Owner 广州玮弘祺生物科技有限公司