A kind of decolorization process of coenzyme I
A technology of coenzyme and process, which is applied in the field of decolorization, can solve the problems affecting the purity of coenzyme I refining, the inability to remove the adsorbed pigment, and reduce the service life of refined packing, so as to achieve the advantages of low price, low load and high reuse rate Effect
Active Publication Date: 2021-01-12
开封康诺药业有限公司
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Problems solved by technology
Therefore, before refining, the coenzyme I extract has a certain color, which has a certain impact on the refining process
[0003] The product needs to be refined during the production process of coenzyme I, but the extract of coenzyme I product is a colored solution. When refining, the color of the solution and the refined filler will act to replace coenzyme I and adsorb on the filler, which seriously affects the refining of coenzyme I. purity, and this process is irreversible, which pollutes the precious refined packing, and the existing technology for processing and maintaining the packing cannot remove the adsorbed pigment, thus greatly reducing the service life of the refined packing and increasing the production cost
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[0018] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
[0019] The steps of the decolorization process of coenzyme I of the present invention are as follows:
[0020] A. Activation of AMK867 resin: first soak AMK867 resin with 4% NaOH solution, and stir for 2 hours, rinse the soaked AMK867 resin with purified water to neutral; rinse the AMK867 resin with concentration Soak in 4% HCl and stir for 2 hours, then rinse with purified water until neutral;
[0021] B. Adsorption: The coenzyme I feed liquid to be decolorized flows throug...
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The invention discloses a decolorizing process of coenzyme I. The process adopts activated AMK867 resin as an adsorption material, and can improve the purity of the coenzyme I after adsorption and decolorizing. Through comparison, the purity measurement results of the coenzyme I in a feed liquid before and after treatment show that: the activated AMK867 resin filler can remove part of impurities in the feed liquid, greatly improves the purity of the coenzyme I, prolongs the storage life of the coenzyme I, and reduces the load of the refined filler. The implementation process is simple to operate, the resin has high recycling rate and long service life, and the resin has low price, can save cost and is suitable for industrial production.
Description
technical field [0001] The invention belongs to the field of decolorization, and in particular relates to a decolorization process of coenzyme I. Background technique [0002] The production of coenzyme I is realized through a series of extraction, separation and purification processes, and the final step is to refine the feed liquid to obtain high-purity coenzyme I materials. Since the yeast liquid is composed of molasses, corn steep liquor, protein powder, yeast extract, etc., the product metabolized by the yeast, after solid-liquid separation from the yeast liquid, after ultrafiltration with a molecular weight of 3000, only the target substance remains And inorganic salts, small molecular pigments, concentrated after nanofiltration, pigments with molecular weights close to the target object are retained, and after concentration, the color is stronger. Therefore, before refining, the coenzyme I extract has a certain color, which has a certain impact on the refining proces...
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IPC IPC(8): C07H19/207C07H1/06
Inventor 金永红郎巧洁潘丽英
Owner 开封康诺药业有限公司