Preparation method of manyflower gueldenstaedtid herb formula granules with effects of clearing heat, removing toxins, cooling blood and diminishing swelling as well as formula granules prepared by method

A technology for formula granules, heat-clearing and detoxification, which is applied in the field of preparation of sweet ditin formula granules, and achieves the effects of easy storage, convenient taking and good granule forming.

Inactive Publication Date: 2019-06-07
JIANGXI GROUNDIONG PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report about sweet ditin formula granules and its preparation process

Method used

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  • Preparation method of manyflower gueldenstaedtid herb formula granules with effects of clearing heat, removing toxins, cooling blood and diminishing swelling as well as formula granules prepared by method
  • Preparation method of manyflower gueldenstaedtid herb formula granules with effects of clearing heat, removing toxins, cooling blood and diminishing swelling as well as formula granules prepared by method

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preparation example Construction

[0028] The preparation method of sweet ditin formula granule of the present invention comprises the following steps:

[0029] (1) Grinding the dried sweet ditin medicinal material to obtain a powder with a particle size of 40-100 mesh;

[0030] (2) Soak the powder obtained in step (1) with 2-5 times the volume of hot water;

[0031] (3) filter, the filter cake obtained is mixed with the aqueous ethanol solution of 15-20 times of volume of feeding amount;

[0032] (4) ultrasonic extraction 2-3 times;

[0033] (5) filter, and the filtrate is concentrated under reduced pressure to a concentrated solution whose relative density is 1.1-1.2;

[0034] (6) mixing the concentrate with pharmaceutically acceptable adjuvants;

[0035] (7) Freeze-drying, collecting the dry cream powder, pulverizing through an 80-mesh sieve, and mixing in a mixing tank;

[0036] (8) Granulate the obtained sweet-sweetened cream powder, and granulate the granules with a 20-mesh sieve and a 50-mesh sieve i...

Embodiment 1

[0052] (1) Take 1 kg of dried sweet ditin, crush it to 80 mesh, add 3 times the amount of hot water (50°C) to soak for 2 hours, filter it with 200 mesh stainless steel wire mesh, and mix the obtained filter cake with 18 times the amount of material mixed ethanol aqueous solution (concentration is 45% by weight), ultrasonically extracted 3 times under the ultrasonic frequency of 90kHz, each extraction was 45 minutes, filtered with 200-mesh stainless steel wire mesh, and the filtrate was concentrated under reduced pressure to a concentrated solution with a relative density of 1.15;

[0053] (2) Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, crush it through an 80-mesh sieve, and mix it in a mixing tank ;

[0054] (3) Take the powder of sweet dithin paste, sieve and granulate the granules, and sieve the granules with a 20-mesh sieve and a 50-mesh si...

Embodiment 2

[0056](1) Take 1 kg of dried sweet ditin medicinal material, crush it to 100 mesh, soak it in hot water (40°C) with 4 times the feeding amount for 3 hours, filter it with 200 mesh stainless steel wire mesh, and mix the obtained filter cake with 16 times the feeding amount The ethanol aqueous solution (concentration is 35% by weight) is mixed, and ultrasonic extraction is carried out 3 times under the ultrasonic frequency of 90kHz, extracts 45 minutes each time, filters with 200 mesh stainless steel screens, and the filtrate is concentrated under reduced pressure to the concentrated solution that relative density is 1.16;

[0057] (2) Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, crush it through an 80-mesh sieve, and mix it in a mixing tank ;

[0058] (3) Take the cinnamon paste powder, sieve and granulate the granules, and granulate the granule...

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Abstract

The invention relates to the technical field of traditional Chinese medicine formula granules and discloses a preparation method of manyflower gueldenstaedtid herb formula granules with effects of clearing heat, removing toxins, cooling blood and diminishing swelling as well as formula granules prepared by the method. The method comprises the following steps: (1) crushing a medicinal material of dried manyflower gueldenstaedtid herb; (2) soaking powder obtained in step (1) by hot water; (3) performing filtration, and mixing an obtained filter cake with ethanol; (4) performing ultrasonic extraction for 2-3 times; (5) performing filtration, and concentrating a filtrate under reduced pressure; (6) mixing a concentrated liquid with pharmaceutically acceptable auxiliary materials; (7) carryingout freeze drying, collecting dry paste powder, crushing and sieving the paste powder by a 80-mesh sieve, and mixing obtained paste powder in a mixing tank; and (8) granulating and shaping the obtained manyflower gueldenstaedtid herb paste powder. The manyflower gueldenstaedtid herb formula granules prepared by the method in the invention have high active component content and uniform granule sizes.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine formula granules, in particular to a preparation method of sweet ditin formula granules with the functions of clearing away heat and detoxification and cooling blood and reducing swelling, and the formula granules prepared by the method. Background technique [0002] Traditional Chinese medicine formula granules are obtained by extracting, separating, concentrating, drying, granulating and packaging the whole ingredients of the medicinal materials through modern processing technology and pharmaceutical technology. They can be directly formulated and packaged without decoction. Granules for ingestion. Traditional Chinese medicine formula granules not only retain the active ingredients, indications and efficacy of traditional Chinese medicine decoction pieces, but also have the advantages that decoction pieces do not have, such as unified standard, stable curative effect, conven...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/36A61K47/26A61K36/485A61P29/00A61P7/10
Inventor 廖年生眭荣春陈小燕
Owner JIANGXI GROUNDIONG PHARM CO LTD
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